ENSG00000278311

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000613102 ENSG00000278311 HEK293_DMSO_6hA HEK293_OSMI2_6hA GGNBP2 protein_coding protein_coding 18.19621 11.99645 11.52376 3.263477 0.6595537 -0.05794666 6.688878 3.373899 4.7784908 1.0630044 1.07646955 0.5008844 0.35866250 0.2782000 0.40893333 0.13073333 0.5525869160 0.0001306131 FALSE TRUE
ENST00000615952 ENSG00000278311 HEK293_DMSO_6hA HEK293_OSMI2_6hA GGNBP2 protein_coding protein_coding 18.19621 11.99645 11.52376 3.263477 0.6595537 -0.05794666 1.287580 1.436622 0.9397228 0.6224475 0.44366673 -0.6071094 0.06982917 0.1106667 0.08566667 -0.02500000 0.7529677585 0.0001306131 FALSE FALSE
ENST00000620927 ENSG00000278311 HEK293_DMSO_6hA HEK293_OSMI2_6hA GGNBP2 protein_coding retained_intron 18.19621 11.99645 11.52376 3.263477 0.6595537 -0.05794666 1.131811 1.764635 0.1762676 0.4952951 0.09527878 -3.2520741 0.07932917 0.1464667 0.01513333 -0.13133333 0.0001306131 0.0001306131 FALSE TRUE
MSTRG.14194.1 ENSG00000278311 HEK293_DMSO_6hA HEK293_OSMI2_6hA GGNBP2 protein_coding   18.19621 11.99645 11.52376 3.263477 0.6595537 -0.05794666 6.661118 3.452529 3.8876522 0.8200806 0.64791897 0.1707793 0.35817917 0.2929667 0.33363333 0.04066667 0.7553403844 0.0001306131 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000278311 E001 0.0000000       17 36544911 36544911 1 +      
ENSG00000278311 E002 0.1125166 0.0323417223 0.5244680454   17 36544912 36544918 7 + 0.115 0.000 -8.539
ENSG00000278311 E003 1.9835529 0.0092731404 0.8906742806 0.97382417 17 36544919 36544931 13 + 0.495 0.474 -0.104
ENSG00000278311 E004 22.7259443 0.0017242178 0.6561412065 0.89919204 17 36544932 36545097 166 + 1.393 1.364 -0.102
ENSG00000278311 E005 3.4518185 0.0606756061 0.2469813366 0.65246274 17 36545504 36545618 115 + 0.727 0.521 -0.901
ENSG00000278311 E006 54.3049099 0.0080221420 0.0479559085 0.33861793 17 36545619 36545817 199 + 1.804 1.679 -0.422
ENSG00000278311 E007 9.4656266 0.0028926663 0.0084457566 0.16031362 17 36545818 36547747 1930 + 1.139 0.861 -1.028
ENSG00000278311 E008 44.4687653 0.0012840822 0.0008843745 0.05055150 17 36554820 36554900 81 + 1.746 1.572 -0.591
ENSG00000278311 E009 81.7871001 0.0060015934 0.0048725864 0.12524142 17 36557083 36557336 254 + 1.990 1.847 -0.480
ENSG00000278311 E010 58.0017906 0.0005528393 0.1222552355 0.49761721 17 36560773 36560871 99 + 1.810 1.744 -0.224
ENSG00000278311 E011 62.8626438 0.0004840619 0.2940243167 0.69463138 17 36567663 36567776 114 + 1.830 1.788 -0.142
ENSG00000278311 E012 10.5317308 0.0280788694 0.0004800429 0.03518088 17 36576657 36577982 1326 + 0.771 1.226 1.688
ENSG00000278311 E013 86.9913846 0.0089376803 0.8138182282 0.95264236 17 36577983 36578186 204 + 1.956 1.938 -0.062
ENSG00000278311 E014 17.0514123 0.0029926199 0.0916313999 0.44134879 17 36578187 36578192 6 + 1.192 1.331 0.490
ENSG00000278311 E015 9.4230652 0.1185269834 0.5728940500 0.86349679 17 36578193 36579244 1052 + 0.945 1.079 0.492
ENSG00000278311 E016 97.0002160 0.0029329456 0.5535371204 0.85526823 17 36579245 36579419 175 + 1.986 2.009 0.076
ENSG00000278311 E017 114.4835249 0.0003401316 0.7386750790 0.92857745 17 36581344 36581538 195 + 2.060 2.073 0.046
ENSG00000278311 E018 1.8552760 0.0101921698 0.1062383005 0.46861987 17 36581539 36582477 939 + 0.282 0.561 1.528
ENSG00000278311 E019 94.0154914 0.0003183122 0.9843327911 0.99621886 17 36585300 36585450 151 + 1.983 1.985 0.007
ENSG00000278311 E020 0.9936064 0.0181954385 0.9235042322   17 36585451 36585839 389 + 0.282 0.299 0.117
ENSG00000278311 E021 64.1915840 0.0004668288 0.9563834433 0.98998920 17 36585840 36585892 53 + 1.818 1.824 0.019
ENSG00000278311 E022 83.3009999 0.0004313095 0.5913629306 0.87200095 17 36585893 36585965 73 + 1.920 1.943 0.079
ENSG00000278311 E023 1.8988606 0.0756496314 0.0059491680 0.13697800 17 36585966 36586049 84 + 0.116 0.635 3.439
ENSG00000278311 E024 82.5866926 0.0004179965 0.4474875093 0.80220455 17 36586050 36586133 84 + 1.913 1.945 0.106
ENSG00000278311 E025 73.6830991 0.0027398194 0.6574259387 0.89965974 17 36586134 36586198 65 + 1.885 1.868 -0.058
ENSG00000278311 E026 14.0596904 0.0788559493 0.0695681375 0.39474272 17 36586199 36586827 629 + 1.011 1.287 0.988
ENSG00000278311 E027 3.5748632 0.0976991088 0.0776198108 0.41276162 17 36586936 36586996 61 + 0.453 0.796 1.513
ENSG00000278311 E028 140.1041132 0.0002444537 0.4599152965 0.80852212 17 36586997 36587245 249 + 2.141 2.165 0.081
ENSG00000278311 E029 11.0742224 0.1395253908 0.2842252648 0.68695027 17 36587246 36587596 351 + 0.974 1.165 0.694
ENSG00000278311 E030 152.5564269 0.0037110447 0.0263230718 0.26369060 17 36589208 36589848 641 + 2.140 2.231 0.306