ENSG00000277053

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000614592 ENSG00000277053 HEK293_DMSO_6hA HEK293_OSMI2_6hA GTF2IP1 transcribed_unprocessed_pseudogene transcribed_unprocessed_pseudogene 19.93354 14.82242 16.45502 2.076177 2.43853 0.1506508 2.376934 0.0000000 0.000000 0.0000000 0.0000000 0.0000000 0.1021417 0.0000000 0.00000000 0.00000000   1.442552e-06 TRUE TRUE
ENST00000616377 ENSG00000277053 HEK293_DMSO_6hA HEK293_OSMI2_6hA GTF2IP1 transcribed_unprocessed_pseudogene processed_transcript 19.93354 14.82242 16.45502 2.076177 2.43853 0.1506508 1.294341 0.4943257 1.478374 0.1045531 0.5544819 1.5613100 0.0630750 0.0335000 0.09353333 0.06003333 4.137746e-01 1.442552e-06 TRUE TRUE
ENST00000618412 ENSG00000277053 HEK293_DMSO_6hA HEK293_OSMI2_6hA GTF2IP1 transcribed_unprocessed_pseudogene retained_intron 19.93354 14.82242 16.45502 2.076177 2.43853 0.1506508 2.045768 4.9894258 1.806855 0.9859884 0.4898988 -1.4603189 0.1177750 0.3321333 0.10716667 -0.22496667 1.442552e-06 1.442552e-06   FALSE
ENST00000621948 ENSG00000277053 HEK293_DMSO_6hA HEK293_OSMI2_6hA GTF2IP1 transcribed_unprocessed_pseudogene retained_intron 19.93354 14.82242 16.45502 2.076177 2.43853 0.1506508 4.040986 2.8610881 2.114277 0.7988575 0.8442571 -0.4346259 0.1969125 0.1894667 0.15406667 -0.03540000 7.519864e-01 1.442552e-06   FALSE
ENST00000622829 ENSG00000277053 HEK293_DMSO_6hA HEK293_OSMI2_6hA GTF2IP1 transcribed_unprocessed_pseudogene processed_transcript 19.93354 14.82242 16.45502 2.076177 2.43853 0.1506508 9.378760 5.6037018 10.609248 0.5760923 2.9028826 0.9196573 0.4803833 0.3863333 0.61546667 0.22913333 2.497003e-01 1.442552e-06 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000277053 E001 0.0000000       7 75185385 75185395 11 -      
ENSG00000277053 E002 23.3270912 0.0090413386 0.01067880 0.17892544 7 75185396 75186115 720 - 1.282 1.500 0.754
ENSG00000277053 E003 21.4639720 0.0015067149 0.01566092 0.21296325 7 75186116 75186527 412 - 1.259 1.453 0.676
ENSG00000277053 E004 3.4574667 0.0278325291 0.08289657 0.42377894 7 75186528 75187060 533 - 0.530 0.811 1.196
ENSG00000277053 E005 1.8341556 0.0110008682 0.56958034 0.86218557 7 75187061 75187219 159 - 0.404 0.516 0.570
ENSG00000277053 E006 4.7525825 0.2454352505 0.73306205 0.92672398 7 75187220 75187241 22 - 0.746 0.716 -0.124
ENSG00000277053 E007 8.6666213 0.2424722501 0.92610833 0.98253742 7 75187242 75187295 54 - 0.943 0.996 0.199
ENSG00000277053 E008 35.6436622 0.0012014463 0.08581231 0.42962686 7 75188075 75188116 42 - 1.567 1.487 -0.274
ENSG00000277053 E009 68.1741389 0.0004425729 0.12174179 0.49679807 7 75189215 75189256 42 - 1.837 1.797 -0.136
ENSG00000277053 E010 4.9144525 0.0504079276 0.00208601 0.08148375 7 75189257 75190538 1282 - 0.504 1.023 2.122
ENSG00000277053 E011 42.4370475 0.0049585691 0.05087985 0.34646596 7 75190539 75190567 29 - 1.659 1.558 -0.344
ENSG00000277053 E012 16.9361594 0.1695188836 0.03098096 0.28321757 7 75190568 75191533 966 - 0.999 1.480 1.701
ENSG00000277053 E013 63.7249256 0.0007144416 0.01970235 0.23417022 7 75192047 75192230 184 - 1.821 1.743 -0.264
ENSG00000277053 E014 1.2583444 0.3070982344 0.68509993   7 75192899 75192980 82 - 0.370 0.281 -0.564
ENSG00000277053 E015 1.9490452 0.0257916466 0.04133010 0.31842891 7 75193903 75193983 81 - 0.536 0.163 -2.416
ENSG00000277053 E016 2.9204318 0.0072681498 0.02040417 0.23785997 7 75194657 75194712 56 - 0.676 0.282 -2.036
ENSG00000277053 E017 3.3730586 0.0083194119 0.03581564 0.29989763 7 75196613 75196667 55 - 0.715 0.375 -1.612
ENSG00000277053 E018 4.5649488 0.0048978986 0.22618125 0.63131043 7 75196668 75196796 129 - 0.782 0.623 -0.663
ENSG00000277053 E019 3.3473841 0.0064513254 0.38887867 0.76630274 7 75196974 75197039 66 - 0.561 0.708 0.637
ENSG00000277053 E020 3.9692186 0.0054864694 0.60620596 0.87819999 7 75197948 75198049 102 - 0.655 0.745 0.377
ENSG00000277053 E021 2.3261660 0.0232806672 0.73934980 0.92893448 7 75199651 75199670 20 - 0.503 0.573 0.329
ENSG00000277053 E022 2.8833537 0.0074097313 0.22364471 0.62852861 7 75199671 75199725 55 - 0.505 0.708 0.903
ENSG00000277053 E023 0.1125166 0.0321131115 0.87958395   7 75199726 75199808 83 - 0.086 0.000 -9.998
ENSG00000277053 E024 0.0000000       7 75199809 75200120 312 -      
ENSG00000277053 E025 2.5351361 0.0431881492 0.48555818 0.82228905 7 75200121 75200179 59 - 0.476 0.621 0.675
ENSG00000277053 E026 3.5340688 0.0160427222 0.27115846 0.67529040 7 75201121 75201304 184 - 0.678 0.516 -0.723
ENSG00000277053 E027 0.2937266 0.0274424043 0.45091395   7 75201305 75201316 12 - 0.158 0.000 -10.947
ENSG00000277053 E028 0.1795728 0.0350612527 0.25583628   7 75201554 75201718 165 - 0.000 0.163 10.829
ENSG00000277053 E029 0.0000000       7 75201865 75201923 59 -      
ENSG00000277053 E030 1.4777512 0.0118339997 0.81163297   7 75202542 75202613 72 - 0.404 0.375 -0.168
ENSG00000277053 E031 0.0000000       7 75205995 75206260 266 -      
ENSG00000277053 E032 0.9120449 0.0151886270 0.41276920   7 75207956 75208014 59 - 0.220 0.375 1.055
ENSG00000277053 E033 2.9117403 0.0070653386 0.77153515 0.93989790 7 75209376 75209559 184 - 0.561 0.623 0.276
ENSG00000277053 E034 1.5587498 0.0117690111 0.67449017   7 75210528 75210599 72 - 0.365 0.451 0.469
ENSG00000277053 E035 0.6999699 0.0193874923 0.08854614   7 75212079 75212137 59 - 0.322 0.000 -12.129
ENSG00000277053 E036 1.2467924 0.0144970101 0.46677338   7 75213406 75213589 184 - 0.404 0.282 -0.749
ENSG00000277053 E037 0.2937266 0.0274424043 0.45091395   7 75215756 75215821 66 - 0.158 0.000 -10.947
ENSG00000277053 E038 0.1812101 0.0338353821 0.87751528   7 75217154 75217264 111 - 0.087 0.000 -9.996
ENSG00000277053 E039 0.0000000       7 75237293 75237694 402 -      
ENSG00000277053 E040 0.0000000       7 75237695 75237696 2 -      
ENSG00000277053 E041 0.0000000       7 75243466 75243609 144 -