ENSG00000275066

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000612223 ENSG00000275066 HEK293_DMSO_6hA HEK293_OSMI2_6hA SYNRG protein_coding protein_coding 5.631061 4.281463 4.811643 1.04453 1.006907 0.1680552 1.9056292 1.9659605 1.3106724 0.1683002 0.2430502 -0.58128149 0.36114167 0.50060000 0.27896667 -0.22163333 2.859003e-01 7.975446e-08 FALSE TRUE
ENST00000614196 ENSG00000275066 HEK293_DMSO_6hA HEK293_OSMI2_6hA SYNRG protein_coding protein_coding 5.631061 4.281463 4.811643 1.04453 1.006907 0.1680552 0.4123447 0.5876455 0.6459614 0.3394478 0.3393232 0.13432081 0.07859583 0.11180000 0.14856667 0.03676667 9.833618e-01 7.975446e-08 FALSE FALSE
ENST00000616179 ENSG00000275066 HEK293_DMSO_6hA HEK293_OSMI2_6hA SYNRG protein_coding protein_coding 5.631061 4.281463 4.811643 1.04453 1.006907 0.1680552 0.4494168 0.4517428 0.3295632 0.1189191 0.3295632 -0.44340911 0.07493333 0.10400000 0.06516667 -0.03883333 5.122518e-01 7.975446e-08 FALSE TRUE
MSTRG.14217.10 ENSG00000275066 HEK293_DMSO_6hA HEK293_OSMI2_6hA SYNRG protein_coding   5.631061 4.281463 4.811643 1.04453 1.006907 0.1680552 0.4117547 0.3155086 0.2950434 0.2082793 0.2950434 -0.09368109 0.07275000 0.05776667 0.04596667 -0.01180000 7.483774e-01 7.975446e-08 FALSE TRUE
MSTRG.14217.12 ENSG00000275066 HEK293_DMSO_6hA HEK293_OSMI2_6hA SYNRG protein_coding   5.631061 4.281463 4.811643 1.04453 1.006907 0.1680552 0.1318446 0.0000000 0.1550459 0.0000000 0.1550459 4.04479539 0.02447500 0.00000000 0.05243333 0.05243333 7.703340e-01 7.975446e-08 FALSE TRUE
MSTRG.14217.13 ENSG00000275066 HEK293_DMSO_6hA HEK293_OSMI2_6hA SYNRG protein_coding   5.631061 4.281463 4.811643 1.04453 1.006907 0.1680552 0.3908423 0.0000000 0.0000000 0.0000000 0.0000000 0.00000000 0.05174167 0.00000000 0.00000000 0.00000000   7.975446e-08 FALSE TRUE
MSTRG.14217.5 ENSG00000275066 HEK293_DMSO_6hA HEK293_OSMI2_6hA SYNRG protein_coding   5.631061 4.281463 4.811643 1.04453 1.006907 0.1680552 0.6194614 0.5261353 0.3330835 0.2672699 0.1693855 -0.64403736 0.10415833 0.10536667 0.05963333 -0.04573333 8.850448e-01 7.975446e-08 FALSE TRUE
MSTRG.14217.6 ENSG00000275066 HEK293_DMSO_6hA HEK293_OSMI2_6hA SYNRG protein_coding   5.631061 4.281463 4.811643 1.04453 1.006907 0.1680552 0.4702485 0.1147703 0.1972622 0.1147703 0.1972622 0.73218162 0.08441250 0.04390000 0.03900000 -0.00490000 9.900744e-01 7.975446e-08 TRUE TRUE
MSTRG.14217.7 ENSG00000275066 HEK293_DMSO_6hA HEK293_OSMI2_6hA SYNRG protein_coding   5.631061 4.281463 4.811643 1.04453 1.006907 0.1680552 0.2598070 0.0000000 1.1742027 0.0000000 0.4417064 6.88777230 0.04420833 0.00000000 0.22256667 0.22256667 7.975446e-08 7.975446e-08 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000275066 E001 35.3809199 0.0016892350 2.903672e-03 9.673596e-02 17 37514807 37515368 562 - 1.441 1.629 0.645
ENSG00000275066 E002 18.0082642 0.0018577473 1.222429e-01 4.976097e-01 17 37515369 37515444 76 - 1.193 1.326 0.467
ENSG00000275066 E003 15.7050347 0.0134789694 3.131107e-01 7.105909e-01 17 37515445 37515568 124 - 1.149 1.258 0.386
ENSG00000275066 E004 84.0129758 0.0004851551 1.695918e-13 1.756431e-09 17 37515569 37517186 1618 - 1.741 2.039 1.002
ENSG00000275066 E005 18.8085206 0.0409957177 4.434007e-03 1.192977e-01 17 37517187 37517342 156 - 1.053 1.423 1.305
ENSG00000275066 E006 24.7825223 0.0914258743 7.200593e-02 3.999608e-01 17 37517343 37517522 180 - 1.228 1.517 1.006
ENSG00000275066 E007 11.9107202 0.0353224606 1.802755e-01 5.795862e-01 17 37517523 37517580 58 - 0.993 1.183 0.687
ENSG00000275066 E008 21.2528917 0.0182711751 1.463052e-02 2.064556e-01 17 37517581 37517829 249 - 1.192 1.443 0.877
ENSG00000275066 E009 38.8422439 0.0008555926 1.340758e-05 3.746639e-03 17 37517830 37518400 571 - 1.440 1.696 0.875
ENSG00000275066 E010 9.8279983 0.0082652429 2.378041e-01 6.430061e-01 17 37518401 37518460 60 - 0.945 1.085 0.516
ENSG00000275066 E011 36.1807357 0.0036172631 3.024009e-01 7.017264e-01 17 37518461 37518687 227 - 1.535 1.606 0.244
ENSG00000275066 E012 28.4302826 0.0093034167 7.648734e-01 9.376053e-01 17 37518688 37518768 81 - 1.451 1.479 0.097
ENSG00000275066 E013 24.5054190 0.0112185669 3.146591e-01 7.119545e-01 17 37518769 37518821 53 - 1.352 1.438 0.298
ENSG00000275066 E014 29.2479591 0.0010460491 9.235319e-01 9.817789e-01 17 37518822 37518886 65 - 1.483 1.484 0.001
ENSG00000275066 E015 47.7585240 0.0006794878 4.898127e-01 8.244832e-01 17 37518887 37519009 123 - 1.669 1.710 0.140
ENSG00000275066 E016 36.2568756 0.0007998785 7.368527e-02 4.035133e-01 17 37519010 37519071 62 - 1.510 1.619 0.373
ENSG00000275066 E017 21.4042016 0.0042285838 5.821442e-01 8.677077e-01 17 37520179 37520214 36 - 1.363 1.326 -0.127
ENSG00000275066 E018 41.2416715 0.0007018023 7.320250e-01 9.263888e-01 17 37520538 37520648 111 - 1.634 1.623 -0.039
ENSG00000275066 E019 1.5822247 0.0418077056 9.582731e-01   17 37529783 37529851 69 - 0.417 0.408 -0.050
ENSG00000275066 E020 37.3906971 0.0008598594 6.554875e-02 3.857475e-01 17 37535979 37536085 107 - 1.631 1.534 -0.332
ENSG00000275066 E021 32.9511648 0.0009405245 4.975777e-02 3.437331e-01 17 37536086 37536127 42 - 1.586 1.475 -0.380
ENSG00000275066 E022 1.4224344 0.0828440476 1.544370e-01   17 37536128 37537478 1351 - 0.217 0.500 1.740
ENSG00000275066 E023 42.6057027 0.0006776103 6.564771e-02 3.860056e-01 17 37538324 37538420 97 - 1.686 1.596 -0.306
ENSG00000275066 E024 39.8074877 0.0008705475 7.686708e-01 9.391349e-01 17 37539192 37539245 54 - 1.603 1.626 0.076
ENSG00000275066 E025 41.8008873 0.0008277088 4.213278e-01 7.869317e-01 17 37540380 37540480 101 - 1.653 1.616 -0.125
ENSG00000275066 E026 30.1042845 0.0018251631 8.806585e-01 9.713547e-01 17 37540481 37540543 63 - 1.493 1.489 -0.014
ENSG00000275066 E027 2.3465724 0.0084271253 7.918950e-03 1.554822e-01 17 37540626 37541971 1346 - 0.217 0.674 2.521
ENSG00000275066 E028 85.9678694 0.0004178768 8.667495e-01 9.673403e-01 17 37541972 37542427 456 - 1.938 1.939 0.003
ENSG00000275066 E029 9.2635716 0.0026492219 8.236682e-01 9.553917e-01 17 37542428 37542430 3 - 1.017 1.000 -0.062
ENSG00000275066 E030 25.7887631 0.0012526714 7.308830e-01 9.259605e-01 17 37542431 37542565 135 - 1.408 1.437 0.100
ENSG00000275066 E031 59.1880950 0.0005637128 5.249324e-02 3.514122e-01 17 37553115 37553415 301 - 1.818 1.738 -0.270
ENSG00000275066 E032 84.7987995 0.0008261919 6.494615e-03 1.419998e-01 17 37553416 37553986 571 - 1.982 1.883 -0.333
ENSG00000275066 E033 23.9035121 0.0082087603 1.312618e-01 5.121597e-01 17 37553987 37554059 73 - 1.455 1.343 -0.388
ENSG00000275066 E034 0.0000000       17 37557140 37557203 64 -      
ENSG00000275066 E035 18.6514808 0.0051584160 9.841608e-02 4.543936e-01 17 37561195 37561257 63 - 1.357 1.225 -0.460
ENSG00000275066 E036 29.8529504 0.0039992152 2.308499e-01 6.358377e-01 17 37561471 37561589 119 - 1.531 1.456 -0.258
ENSG00000275066 E037 0.6233207 0.0193874923 9.502229e-01   17 37566849 37568790 1942 - 0.217 0.210 -0.061
ENSG00000275066 E038 29.8750874 0.0010910299 5.020554e-01 8.307033e-01 17 37568791 37568924 134 - 1.510 1.475 -0.122
ENSG00000275066 E039 41.7597437 0.0007646216 7.694065e-01 9.393125e-01 17 37570637 37570885 249 - 1.637 1.629 -0.029
ENSG00000275066 E040 20.0679119 0.0113689172 4.182276e-01 7.853046e-01 17 37571791 37571832 42 - 1.364 1.299 -0.224
ENSG00000275066 E041 31.2723089 0.0010311315 3.325003e-02 2.913569e-01 17 37571833 37571987 155 - 1.575 1.452 -0.421
ENSG00000275066 E042 19.5204463 0.0015338485 3.731896e-02 3.049349e-01 17 37576341 37576418 78 - 1.386 1.234 -0.532
ENSG00000275066 E043 0.0000000       17 37576419 37576480 62 -      
ENSG00000275066 E044 15.1495683 0.0026734509 1.597364e-03 7.052961e-02 17 37577380 37577446 67 - 1.331 1.062 -0.953
ENSG00000275066 E045 21.1903635 0.0012068844 1.711974e-03 7.342035e-02 17 37577447 37577613 167 - 1.450 1.226 -0.782
ENSG00000275066 E046 13.9555686 0.0043484373 1.633851e-02 2.167115e-01 17 37579132 37579434 303 - 1.275 1.062 -0.758
ENSG00000275066 E047 0.3794938 0.0603670332 5.508718e-01   17 37584322 37584647 326 - 0.215 0.117 -1.048
ENSG00000275066 E048 15.9436465 0.0016077406 4.637328e-04 3.453245e-02 17 37584648 37584759 112 - 1.362 1.074 -1.020
ENSG00000275066 E049 11.9148226 0.0028750266 5.269426e-02 3.519513e-01 17 37585325 37585341 17 - 1.193 1.013 -0.649
ENSG00000275066 E050 19.9392800 0.0015138207 9.170491e-03 1.669208e-01 17 37585342 37585430 89 - 1.409 1.218 -0.667
ENSG00000275066 E051 23.7177206 0.0031786553 7.817988e-02 4.140071e-01 17 37586419 37586549 131 - 1.446 1.326 -0.417
ENSG00000275066 E052 17.1804227 0.0158584037 3.603092e-01 7.470486e-01 17 37596223 37596341 119 - 1.292 1.211 -0.287
ENSG00000275066 E053 5.2295612 0.0060705874 3.877568e-01 7.656742e-01 17 37596342 37596344 3 - 0.717 0.839 0.486
ENSG00000275066 E054 6.6742445 0.0045793862 3.870913e-01 7.651974e-01 17 37600363 37600403 41 - 0.814 0.927 0.435
ENSG00000275066 E055 0.0000000       17 37600404 37600988 585 -      
ENSG00000275066 E056 6.1524514 0.0039693722 7.738896e-01 9.405311e-01 17 37609279 37609367 89 - 0.834 0.876 0.162
ENSG00000275066 E057 2.2829059 0.0244586092 1.774738e-01 5.760936e-01 17 37609368 37609472 105 - 0.626 0.407 -1.058