ENSG00000266074

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000307745 ENSG00000266074 HEK293_DMSO_6hA HEK293_OSMI2_6hA BAHCC1 protein_coding protein_coding 7.91119 9.08483 9.504105 0.6068438 0.7951377 0.06502126 0.7103133 0.5233345 1.7041595 0.5233345 0.3845263 1.6843889 0.09330417 0.05116667 0.17873333 0.127566667 2.653947e-01 3.288702e-14 FALSE TRUE
ENST00000578541 ENSG00000266074 HEK293_DMSO_6hA HEK293_OSMI2_6hA BAHCC1 protein_coding retained_intron 7.91119 9.08483 9.504105 0.6068438 0.7951377 0.06502126 0.4800792 1.1083811 0.2614789 0.1473401 0.2614789 -2.0425002 0.04581250 0.12203333 0.02876667 -0.093266667 2.656423e-01 3.288702e-14 FALSE FALSE
ENST00000582709 ENSG00000266074 HEK293_DMSO_6hA HEK293_OSMI2_6hA BAHCC1 protein_coding retained_intron 7.91119 9.08483 9.504105 0.6068438 0.7951377 0.06502126 2.8777279 3.7059835 3.4139350 0.1680435 0.3994752 -0.1180888 0.32558750 0.40920000 0.35923333 -0.049966667 7.357203e-01 3.288702e-14 FALSE TRUE
ENST00000583828 ENSG00000266074 HEK293_DMSO_6hA HEK293_OSMI2_6hA BAHCC1 protein_coding processed_transcript 7.91119 9.08483 9.504105 0.6068438 0.7951377 0.06502126 0.7725376 0.4945970 0.5542589 0.1536926 0.1484166 0.1612255 0.09286250 0.05270000 0.05693333 0.004233333 9.682548e-01 3.288702e-14   FALSE
ENST00000584330 ENSG00000266074 HEK293_DMSO_6hA HEK293_OSMI2_6hA BAHCC1 protein_coding retained_intron 7.91119 9.08483 9.504105 0.6068438 0.7951377 0.06502126 0.4982366 0.9217350 0.5386777 0.1924207 0.2794985 -0.7639608 0.06351250 0.09986667 0.05486667 -0.045000000 7.269260e-01 3.288702e-14 FALSE FALSE
ENST00000675386 ENSG00000266074 HEK293_DMSO_6hA HEK293_OSMI2_6hA BAHCC1 protein_coding protein_coding 7.91119 9.08483 9.504105 0.6068438 0.7951377 0.06502126 0.6933721 0.3811656 0.7097052 0.1706470 0.2399553 0.8796265 0.11360417 0.04046667 0.07630000 0.035833333 7.319023e-01 3.288702e-14 FALSE TRUE
MSTRG.15274.5 ENSG00000266074 HEK293_DMSO_6hA HEK293_OSMI2_6hA BAHCC1 protein_coding   7.91119 9.08483 9.504105 0.6068438 0.7951377 0.06502126 0.6907558 0.0000000 1.3767112 0.0000000 0.1698955 7.1155236 0.10482917 0.00000000 0.14460000 0.144600000 3.288702e-14 3.288702e-14 FALSE TRUE
MSTRG.15274.7 ENSG00000266074 HEK293_DMSO_6hA HEK293_OSMI2_6hA BAHCC1 protein_coding   7.91119 9.08483 9.504105 0.6068438 0.7951377 0.06502126 0.4541661 1.3246440 0.0000000 0.4714594 0.0000000 -7.0603112 0.04951667 0.15366667 0.00000000 -0.153666667 3.072951e-05 3.288702e-14 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000266074 E001 2.4142161 0.0089109785 0.7792861438 0.942122834 17 81395457 81395471 15 + 0.545 0.501 -0.210
ENSG00000266074 E002 2.7035033 0.0095734177 0.4955550979 0.827165598 17 81395472 81395474 3 + 0.609 0.501 -0.500
ENSG00000266074 E003 7.5518645 0.0538780120 0.9967428811 0.999215156 17 81395475 81395635 161 + 0.925 0.916 -0.034
ENSG00000266074 E004 7.9133396 0.0031495379 0.9039004334 0.977239216 17 81399534 81399739 206 + 0.944 0.934 -0.040
ENSG00000266074 E005 0.9703733 0.1614500347 0.5205659685   17 81399740 81399773 34 + 0.369 0.237 -0.889
ENSG00000266074 E006 10.5975567 0.0728440312 0.9979424584 0.999395937 17 81399774 81399917 144 + 1.040 1.089 0.178
ENSG00000266074 E007 3.2561031 0.0137595910 0.7472364803 0.931817487 17 81401090 81401411 322 + 0.638 0.590 -0.211
ENSG00000266074 E008 34.5302190 0.0008975604 0.5283968180 0.844196378 17 81401412 81402979 1568 + 1.529 1.570 0.138
ENSG00000266074 E009 4.8478010 0.1276612990 0.5828327175 0.868060004 17 81426800 81426803 4 + 0.783 0.731 -0.208
ENSG00000266074 E010 18.9544180 0.0087316152 0.8872268187 0.973007736 17 81426804 81426979 176 + 1.278 1.297 0.069
ENSG00000266074 E011 20.6395704 0.0013460551 0.6780875522 0.907414630 17 81438370 81438492 123 + 1.340 1.312 -0.098
ENSG00000266074 E012 29.5289604 0.0021793859 0.2282720279 0.633497396 17 81441831 81441956 126 + 1.508 1.432 -0.264
ENSG00000266074 E013 107.6212854 0.0021449391 0.0481196246 0.339192731 17 81441957 81443212 1256 + 2.072 1.996 -0.255
ENSG00000266074 E014 40.4744722 0.0060818326 0.5692338749 0.862048610 17 81443213 81443464 252 + 1.626 1.595 -0.105
ENSG00000266074 E015 20.7244204 0.0014097777 0.3307046681 0.725185095 17 81443465 81443564 100 + 1.366 1.296 -0.243
ENSG00000266074 E016 16.5827269 0.0017127021 0.2002611233 0.603777232 17 81443809 81443917 109 + 1.293 1.189 -0.365
ENSG00000266074 E017 0.9495495 0.0153787590 0.2619567257   17 81443918 81444273 356 + 0.192 0.388 1.376
ENSG00000266074 E018 13.3648317 0.0019862186 0.2691705761 0.673745706 17 81444381 81444568 188 + 1.197 1.099 -0.351
ENSG00000266074 E019 14.6434871 0.0231273030 0.9079876468 0.978100874 17 81444668 81444826 159 + 1.182 1.180 -0.009
ENSG00000266074 E020 17.3026151 0.0017282690 0.5359248592 0.847869742 17 81445015 81445178 164 + 1.275 1.228 -0.165
ENSG00000266074 E021 26.4972872 0.0010957226 0.6055039295 0.877827278 17 81445354 81445681 328 + 1.451 1.420 -0.108
ENSG00000266074 E022 4.9791456 0.0048658801 0.7418618603 0.929842381 17 81446738 81446830 93 + 0.798 0.755 -0.170
ENSG00000266074 E023 99.6349455 0.0010956816 0.4084753997 0.779365915 17 81447036 81447848 813 + 2.012 1.984 -0.092
ENSG00000266074 E024 47.6997177 0.0050656247 0.9955295998 0.998771369 17 81451668 81451870 203 + 1.681 1.681 0.001
ENSG00000266074 E025 37.4500152 0.0008399961 0.0069175302 0.146604043 17 81451971 81452107 137 + 1.645 1.491 -0.525
ENSG00000266074 E026 46.1158006 0.0086020880 0.3998011745 0.773191843 17 81452723 81452851 129 + 1.702 1.644 -0.198
ENSG00000266074 E027 51.2314675 0.0011255532 0.2241534869 0.628977227 17 81455267 81455390 124 + 1.746 1.687 -0.200
ENSG00000266074 E028 4.2852889 0.0151430762 0.0040725275 0.114180410 17 81456158 81456296 139 + 0.470 0.895 1.813
ENSG00000266074 E029 68.9335133 0.0004210013 0.4100909902 0.780392149 17 81456297 81456585 289 + 1.858 1.827 -0.107
ENSG00000266074 E030 57.7201678 0.0004754534 0.2413476263 0.646363148 17 81457410 81457592 183 + 1.790 1.739 -0.172
ENSG00000266074 E031 64.6665723 0.0005866015 0.9673406534 0.992487242 17 81458165 81458466 302 + 1.813 1.817 0.015
ENSG00000266074 E032 44.1402759 0.0007404892 0.5984916577 0.875033785 17 81458621 81458725 105 + 1.634 1.664 0.103
ENSG00000266074 E033 58.6099105 0.0005522272 0.2925448024 0.693464176 17 81458813 81458969 157 + 1.790 1.745 -0.154
ENSG00000266074 E034 44.8770471 0.0040738996 0.0412421127 0.318079971 17 81459054 81459168 115 + 1.706 1.591 -0.391
ENSG00000266074 E035 42.5925506 0.0042817271 0.0540254425 0.355890416 17 81459253 81459328 76 + 1.685 1.575 -0.376
ENSG00000266074 E036 0.1812101 0.0480138659 0.6052398846   17 81459391 81459495 105 + 0.107 0.000 -8.811
ENSG00000266074 E037 46.8047895 0.0016998606 0.6728034638 0.905109591 17 81459496 81459604 109 + 1.690 1.671 -0.064
ENSG00000266074 E038 48.6697317 0.0005818447 0.5475276684 0.853026520 17 81460277 81460396 120 + 1.708 1.681 -0.092
ENSG00000266074 E039 56.1660076 0.0010139929 0.9586737543 0.990492531 17 81460530 81460706 177 + 1.753 1.753 -0.001
ENSG00000266074 E040 18.5188476 0.0162828084 0.3074507020 0.705702377 17 81460866 81460889 24 + 1.230 1.336 0.369
ENSG00000266074 E041 193.1743483 0.0004359003 0.1643686587 0.559645073 17 81460890 81462046 1157 + 2.266 2.304 0.128
ENSG00000266074 E042 4.4545543 0.2636748813 0.2392959816 0.644531278 17 81462559 81462739 181 + 0.580 0.869 1.193
ENSG00000266074 E043 100.6395832 0.0003324048 0.1673387920 0.563641716 17 81462740 81462976 237 + 1.979 2.030 0.171
ENSG00000266074 E044 603.0690850 0.0006227129 0.0000368093 0.007191876 17 81463611 81466373 2763 + 2.747 2.814 0.221