ENSG00000249087

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000335648 ENSG00000249087 HEK293_DMSO_6hA HEK293_OSMI2_6hA ZNF436-AS1 lncRNA lncRNA 2.446308 3.803058 3.267846 0.160084 0.0394381 -0.2182004 0.8524789 1.5709425 1.2190810 0.2002884 0.2094533 -0.3632049 0.37123333 0.41023333 0.37410000 -0.03613333 8.757925e-01 2.396391e-05 FALSE FALSE
ENST00000364535 ENSG00000249087 HEK293_DMSO_6hA HEK293_OSMI2_6hA ZNF436-AS1 lncRNA misc_RNA 2.446308 3.803058 3.267846 0.160084 0.0394381 -0.2182004 0.2240665 0.6636724 0.0000000 0.1325534 0.0000000 -6.0739753 0.08032917 0.17783333 0.00000000 -0.17783333 2.396391e-05 2.396391e-05   FALSE
ENST00000437367 ENSG00000249087 HEK293_DMSO_6hA HEK293_OSMI2_6hA ZNF436-AS1 lncRNA lncRNA 2.446308 3.803058 3.267846 0.160084 0.0394381 -0.2182004 0.1913782 0.4896172 0.2648658 0.1266582 0.1894846 -0.8620955 0.08112917 0.13180000 0.07976667 -0.05203333 7.397827e-01 2.396391e-05   FALSE
ENST00000454117 ENSG00000249087 HEK293_DMSO_6hA HEK293_OSMI2_6hA ZNF436-AS1 lncRNA lncRNA 2.446308 3.803058 3.267846 0.160084 0.0394381 -0.2182004 0.4400310 0.6849626 0.8323119 0.1808101 0.4357601 0.2774193 0.16751667 0.17706667 0.25780000 0.08073333 9.887153e-01 2.396391e-05 FALSE FALSE
ENST00000690463 ENSG00000249087 HEK293_DMSO_6hA HEK293_OSMI2_6hA ZNF436-AS1 lncRNA lncRNA 2.446308 3.803058 3.267846 0.160084 0.0394381 -0.2182004 0.4822435 0.1722244 0.4932941 0.1722244 0.2691930 1.4656856 0.20996250 0.04773333 0.14940000 0.10166667 6.948956e-01 2.396391e-05   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000249087 E001 0.8056957 0.0219308011 0.207912065   1 23368949 23368962 14 + 0.125 0.343 1.854
ENSG00000249087 E002 0.8056957 0.0219308011 0.207912065   1 23368963 23368963 1 + 0.125 0.343 1.854
ENSG00000249087 E003 3.6195155 0.0065356372 0.989036168 0.99726923 1 23368964 23368988 25 + 0.669 0.664 -0.022
ENSG00000249087 E004 4.9537950 0.0048241134 0.660119878 0.90068355 1 23368989 23368996 8 + 0.802 0.742 -0.242
ENSG00000249087 E005 8.9029866 0.0067273107 0.310186245 0.70823791 1 23368997 23369029 33 + 1.043 0.931 -0.415
ENSG00000249087 E006 19.2336878 0.0014760461 0.101787485 0.46065682 1 23369030 23369222 193 + 1.369 1.244 -0.434
ENSG00000249087 E007 9.6437795 0.0329983374 0.066011953 0.38672045 1 23369223 23369235 13 + 1.151 0.913 -0.869
ENSG00000249087 E008 9.3500529 0.0326996301 0.097371267 0.45263573 1 23369236 23369237 2 + 1.130 0.913 -0.796
ENSG00000249087 E009 17.3252483 0.0241206409 0.201611477 0.60522158 1 23369238 23369324 87 + 1.333 1.204 -0.452
ENSG00000249087 E010 25.2132676 0.0011334561 0.486528147 0.82276677 1 23369325 23369513 189 + 1.442 1.394 -0.168
ENSG00000249087 E011 43.7939671 0.0067496124 0.051952438 0.34967452 1 23369514 23370253 740 + 1.581 1.689 0.367
ENSG00000249087 E012 52.8735397 0.0007487598 0.001470937 0.06757623 1 23370254 23371138 885 + 1.641 1.780 0.471
ENSG00000249087 E013 16.7385855 0.0019997979 0.324175083 0.72019639 1 23371139 23371209 71 + 1.287 1.205 -0.288
ENSG00000249087 E014 28.1771289 0.0084859776 0.553070512 0.85515619 1 23371210 23371473 264 + 1.489 1.438 -0.175
ENSG00000249087 E015 12.8345861 0.0020867378 0.588606152 0.87072696 1 23371474 23371512 39 + 1.167 1.115 -0.185
ENSG00000249087 E016 26.5023744 0.0028449061 0.127898896 0.50706462 1 23371513 23371839 327 + 1.375 1.476 0.348