ENSG00000246067

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000526795 ENSG00000246067 HEK293_DMSO_6hA HEK293_OSMI2_6hA   lncRNA lncRNA 17.49242 10.7079 11.5675 1.986876 1.007665 0.111301 1.5542664 0.5669245 1.8263413 0.1537199 0.2838430 1.67037981 0.09347917 0.05673333 0.16486667 0.108133333 2.211835e-01 1.161582e-05    
ENST00000533528 ENSG00000246067 HEK293_DMSO_6hA HEK293_OSMI2_6hA   lncRNA lncRNA 17.49242 10.7079 11.5675 1.986876 1.007665 0.111301 1.1216829 1.0178741 1.0723704 0.1551450 0.2746628 0.07453064 0.06654167 0.09653333 0.09116667 -0.005366667 9.620619e-01 1.161582e-05    
ENST00000533708 ENSG00000246067 HEK293_DMSO_6hA HEK293_OSMI2_6hA   lncRNA lncRNA 17.49242 10.7079 11.5675 1.986876 1.007665 0.111301 0.4581905 0.0000000 0.8161030 0.0000000 0.1963672 6.36824973 0.02837917 0.00000000 0.07403333 0.074033333 1.161582e-05 1.161582e-05    
ENST00000669005 ENSG00000246067 HEK293_DMSO_6hA HEK293_OSMI2_6hA   lncRNA lncRNA 17.49242 10.7079 11.5675 1.986876 1.007665 0.111301 0.5997756 0.9427399 0.3854504 0.2857627 0.0726693 -1.26858554 0.03802500 0.08513333 0.03330000 -0.051833333 2.118652e-01 1.161582e-05    
MSTRG.6093.1 ENSG00000246067 HEK293_DMSO_6hA HEK293_OSMI2_6hA   lncRNA   17.49242 10.7079 11.5675 1.986876 1.007665 0.111301 3.0906169 2.4999918 1.6342377 0.4414220 0.3581842 -0.61026379 0.18299167 0.24273333 0.14866667 -0.094066667 5.679398e-01 1.161582e-05    
MSTRG.6093.16 ENSG00000246067 HEK293_DMSO_6hA HEK293_OSMI2_6hA   lncRNA   17.49242 10.7079 11.5675 1.986876 1.007665 0.111301 1.2779406 1.6581771 0.4518307 0.9017044 0.4518307 -1.85283656 0.07351250 0.15760000 0.03420000 -0.123400000 7.169365e-01 1.161582e-05    
MSTRG.6093.20 ENSG00000246067 HEK293_DMSO_6hA HEK293_OSMI2_6hA   lncRNA   17.49242 10.7079 11.5675 1.986876 1.007665 0.111301 6.0651724 1.5279460 3.5378097 0.7702629 1.3689499 1.20592383 0.32764583 0.12753333 0.29200000 0.164466667 6.546932e-01 1.161582e-05    
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000246067 E001 0.0000000       11 83072052 83072065 14 +      
ENSG00000246067 E002 0.0000000       11 83072066 83072068 3 +      
ENSG00000246067 E003 1.8004639 0.0106940116 5.490719e-01 0.853575644 11 83072069 83072081 13 + 0.376 0.483 0.565
ENSG00000246067 E004 12.2364371 0.0021138440 8.820599e-01 0.971758702 11 83072082 83072096 15 + 1.105 1.122 0.063
ENSG00000246067 E005 14.0712822 0.0017966662 6.510386e-01 0.896961612 11 83072097 83072102 6 + 1.149 1.192 0.155
ENSG00000246067 E006 14.6644883 0.0017227457 5.399555e-01 0.849804322 11 83072103 83072103 1 + 1.159 1.216 0.201
ENSG00000246067 E007 15.3342535 0.0016851635 3.299354e-01 0.724551512 11 83072104 83072107 4 + 1.159 1.246 0.306
ENSG00000246067 E008 25.2026442 0.0011319296 4.600459e-01 0.808633693 11 83072108 83072117 10 + 1.382 1.435 0.184
ENSG00000246067 E009 35.8124699 0.0008384139 5.230461e-01 0.841628649 11 83072118 83072121 4 + 1.582 1.549 -0.113
ENSG00000246067 E010 41.3104085 0.0006874580 4.631836e-01 0.810298504 11 83072122 83072137 16 + 1.644 1.609 -0.119
ENSG00000246067 E011 44.2808672 0.0006407742 4.531734e-01 0.805151089 11 83072138 83072146 9 + 1.673 1.639 -0.117
ENSG00000246067 E012 18.4966264 0.0016727413 1.361031e-01 0.519426552 11 83072147 83072161 15 + 1.343 1.231 -0.391
ENSG00000246067 E013 19.8892343 0.0014215852 5.139463e-02 0.348012156 11 83072162 83072181 20 + 1.388 1.246 -0.496
ENSG00000246067 E014 6.8980273 0.0066633218 9.766768e-01 0.994541507 11 83072182 83072342 161 + 0.897 0.903 0.022
ENSG00000246067 E015 2.5843299 0.3499917369 8.433473e-01 0.961110902 11 83072343 83072354 12 + 0.544 0.587 0.196
ENSG00000246067 E016 3.5471620 0.3353530772 9.515823e-01 0.988701770 11 83072355 83072431 77 + 0.681 0.652 -0.124
ENSG00000246067 E017 8.4293600 0.0032246844 5.336303e-01 0.847000307 11 83072432 83072622 191 + 0.999 0.933 -0.243
ENSG00000246067 E018 74.8488149 0.0004509918 2.889697e-01 0.690579598 11 83072623 83072702 80 + 1.897 1.860 -0.124
ENSG00000246067 E019 74.3235706 0.0004989268 1.015859e-01 0.460326992 11 83072703 83072804 102 + 1.908 1.849 -0.198
ENSG00000246067 E020 15.5693908 0.0154643096 6.320993e-01 0.888860582 11 83072805 83073302 498 + 1.233 1.184 -0.176
ENSG00000246067 E021 61.3762772 0.0005978974 9.588218e-01 0.990501815 11 83073303 83073447 145 + 1.794 1.796 0.005
ENSG00000246067 E022 42.2121020 0.0007480465 1.395278e-01 0.524478453 11 83073448 83075492 2045 + 1.586 1.667 0.276
ENSG00000246067 E023 2.7405715 0.0071701612 1.795596e-01 0.578738679 11 83077034 83077173 140 + 0.435 0.653 1.022
ENSG00000246067 E024 1.0565882 0.1251247224 1.435850e-01   11 83077633 83077684 52 + 0.127 0.436 2.342
ENSG00000246067 E025 0.9821418 0.1870334488 5.603645e-01   11 83081535 83081654 120 + 0.369 0.270 -0.632
ENSG00000246067 E026 0.6892119 0.0289706081 2.388458e-01   11 83081673 83081695 23 + 0.310 0.111 -1.835
ENSG00000246067 E027 1.0405529 0.0160914460 8.318234e-01   11 83081696 83081800 105 + 0.309 0.273 -0.245
ENSG00000246067 E028 38.1390328 0.0083366993 3.711732e-06 0.001500165 11 83086137 83087982 1846 + 1.372 1.702 1.130
ENSG00000246067 E029 2.5586110 0.0077969268 7.281291e-01 0.925062097 11 83091253 83091477 225 + 0.575 0.523 -0.241
ENSG00000246067 E030 2.9189793 0.0072049213 5.769905e-01 0.865362687 11 83092033 83092338 306 + 0.533 0.624 0.409
ENSG00000246067 E031 0.0000000       11 83099945 83099970 26 +      
ENSG00000246067 E032 0.3535412 0.2870573739 2.228387e-01   11 83101672 83101718 47 + 0.233 0.000 -10.624
ENSG00000246067 E033 3.0550609 0.0072513286 4.088833e-01 0.779575482 11 83106479 83107789 1311 + 0.680 0.559 -0.528