ENSG00000245958

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000500559 ENSG00000245958 HEK293_DMSO_6hA HEK293_OSMI2_6hA   transcribed_unprocessed_pseudogene processed_transcript 7.879203 8.368898 5.282499 2.099653 0.3054264 -0.6628113 0.0989550 0.0000000 0.32172458 0.0000000 0.07417913 5.0519140 0.01703750 0.00000000 0.06300000 0.063000000 0.0002082224 0.0002082224   FALSE
ENST00000503038 ENSG00000245958 HEK293_DMSO_6hA HEK293_OSMI2_6hA   transcribed_unprocessed_pseudogene retained_intron 7.879203 8.368898 5.282499 2.099653 0.3054264 -0.6628113 0.6297551 1.4916884 0.73243125 0.4296876 0.02832529 -1.0162562 0.08532500 0.17530000 0.13963333 -0.035666667 0.7397083159 0.0002082224   FALSE
ENST00000686002 ENSG00000245958 HEK293_DMSO_6hA HEK293_OSMI2_6hA   transcribed_unprocessed_pseudogene processed_transcript 7.879203 8.368898 5.282499 2.099653 0.3054264 -0.6628113 0.9827757 1.1055100 0.80694790 0.1670515 0.10022840 -0.4493875 0.13391667 0.14570000 0.15513333 0.009433333 0.9296236821 0.0002082224   FALSE
ENST00000688315 ENSG00000245958 HEK293_DMSO_6hA HEK293_OSMI2_6hA   transcribed_unprocessed_pseudogene processed_transcript 7.879203 8.368898 5.282499 2.099653 0.3054264 -0.6628113 1.0242582 0.2064015 0.87729402 0.1141696 0.17971103 2.0357017 0.12791667 0.02233333 0.16890000 0.146566667 0.1069885109 0.0002082224   FALSE
ENST00000688857 ENSG00000245958 HEK293_DMSO_6hA HEK293_OSMI2_6hA   transcribed_unprocessed_pseudogene processed_transcript 7.879203 8.368898 5.282499 2.099653 0.3054264 -0.6628113 0.7307346 0.0000000 0.02943231 0.0000000 0.02943231 1.9793782 0.08059583 0.00000000 0.00520000 0.005200000 0.6437867747 0.0002082224   FALSE
ENST00000692067 ENSG00000245958 HEK293_DMSO_6hA HEK293_OSMI2_6hA   transcribed_unprocessed_pseudogene processed_transcript 7.879203 8.368898 5.282499 2.099653 0.3054264 -0.6628113 0.4597879 0.3379053 0.11946453 0.1999550 0.08146729 -1.4261378 0.05668750 0.05373333 0.02253333 -0.031200000 0.8459989337 0.0002082224   FALSE
ENST00000693650 ENSG00000245958 HEK293_DMSO_6hA HEK293_OSMI2_6hA   transcribed_unprocessed_pseudogene processed_transcript 7.879203 8.368898 5.282499 2.099653 0.3054264 -0.6628113 1.0623071 1.4908322 0.52642612 0.3271948 0.07679919 -1.4843113 0.14422917 0.18100000 0.09860000 -0.082400000 0.2798769040 0.0002082224   FALSE
MSTRG.25407.14 ENSG00000245958 HEK293_DMSO_6hA HEK293_OSMI2_6hA   transcribed_unprocessed_pseudogene   7.879203 8.368898 5.282499 2.099653 0.3054264 -0.6628113 0.5975377 0.4898034 0.38415550 0.1398223 0.11798962 -0.3425958 0.07355417 0.05886667 0.07060000 0.011733333 0.8804369740 0.0002082224   FALSE
MSTRG.25407.32 ENSG00000245958 HEK293_DMSO_6hA HEK293_OSMI2_6hA   transcribed_unprocessed_pseudogene   7.879203 8.368898 5.282499 2.099653 0.3054264 -0.6628113 0.4557946 1.2341351 0.28694217 0.6319889 0.04838529 -2.0668892 0.05495833 0.13033333 0.05580000 -0.074533333 0.3348045835 0.0002082224   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000245958 E001 0.0000000       4 119454762 119454784 23 +      
ENSG00000245958 E002 0.1795728 0.0349555893 7.215048e-01   4 119454785 119454790 6 + 0.000 0.099 9.847
ENSG00000245958 E003 0.1795728 0.0349555893 7.215048e-01   4 119454791 119454793 3 + 0.000 0.099 12.269
ENSG00000245958 E004 0.1795728 0.0349555893 7.215048e-01   4 119454794 119454795 2 + 0.000 0.099 12.269
ENSG00000245958 E005 0.4884942 0.0221824109 1.764550e-01   4 119454796 119454800 5 + 0.000 0.247 13.773
ENSG00000245958 E006 1.4396810 0.0124920332 7.155598e-01   4 119454801 119454809 9 + 0.339 0.403 0.373
ENSG00000245958 E007 1.6192538 0.0111225712 5.442604e-01   4 119454810 119454813 4 + 0.339 0.445 0.596
ENSG00000245958 E008 1.6192538 0.0111225712 5.442604e-01   4 119454814 119454814 1 + 0.339 0.445 0.596
ENSG00000245958 E009 2.3297405 0.0087678979 1.566327e-01 0.5490178021 4 119454815 119454825 11 + 0.339 0.581 1.249
ENSG00000245958 E010 2.8377423 0.0077267974 3.961634e-01 0.7705968640 4 119454826 119454829 4 + 0.473 0.609 0.636
ENSG00000245958 E011 4.7036862 0.0050775845 4.495230e-02 0.3298352959 4 119454830 119454838 9 + 0.527 0.821 1.248
ENSG00000245958 E012 5.3724672 0.0044059470 2.795676e-01 0.6829134206 4 119454839 119454845 7 + 0.693 0.837 0.576
ENSG00000245958 E013 5.6986961 0.0040860916 1.840306e-01 0.5844304936 4 119454846 119454847 2 + 0.693 0.868 0.696
ENSG00000245958 E014 5.6986961 0.0040860916 1.840306e-01 0.5844304936 4 119454848 119454849 2 + 0.693 0.868 0.696
ENSG00000245958 E015 6.0954974 0.0039170734 3.178781e-01 0.7149388616 4 119454850 119454853 4 + 0.757 0.883 0.491
ENSG00000245958 E016 7.0751615 0.0037087033 4.635935e-01 0.8104662783 4 119454854 119454859 6 + 0.839 0.924 0.326
ENSG00000245958 E017 8.0558999 0.0030694574 6.158249e-01 0.8824816459 4 119454860 119454863 4 + 0.908 0.962 0.205
ENSG00000245958 E018 13.0481011 0.0023471357 9.224988e-01 0.9815132698 4 119454864 119454895 32 + 1.133 1.139 0.020
ENSG00000245958 E019 28.2290748 0.0098618071 1.059283e-01 0.4682149636 4 119454896 119455133 238 + 1.531 1.398 -0.456
ENSG00000245958 E020 0.3535412 0.2576066168 1.562930e-01   4 119457968 119457970 3 + 0.258 0.000 -14.291
ENSG00000245958 E021 2.7459885 0.0283583729 5.460272e-01 0.8523859152 4 119457971 119458077 107 + 0.619 0.518 -0.458
ENSG00000245958 E022 2.0473924 0.0146676114 9.519770e-01 0.9887842145 4 119458078 119458170 93 + 0.473 0.483 0.050
ENSG00000245958 E023 0.7303593 0.4218760373 6.512076e-01   4 119458171 119458238 68 + 0.140 0.299 1.380
ENSG00000245958 E024 19.9847047 0.0065791054 1.790141e-01 0.5779687274 4 119460183 119460242 60 + 1.377 1.264 -0.394
ENSG00000245958 E025 0.4884942 0.0221824109 1.764550e-01   4 119460243 119460244 2 + 0.000 0.247 13.773
ENSG00000245958 E026 0.6183183 0.0191904361 5.504522e-01   4 119460437 119460730 294 + 0.144 0.247 0.962
ENSG00000245958 E027 13.3175117 0.0021808482 8.791235e-02 0.4340930994 4 119460731 119460742 12 + 1.234 1.078 -0.557
ENSG00000245958 E028 15.1622496 0.0019263235 6.036142e-01 0.8772201778 4 119460743 119460820 78 + 1.224 1.177 -0.166
ENSG00000245958 E029 6.1396444 0.0041967680 6.105339e-01 0.8802355336 4 119460821 119460827 7 + 0.886 0.820 -0.252
ENSG00000245958 E030 20.3775253 0.0041747717 2.311165e-01 0.6361491312 4 119461717 119461851 135 + 1.371 1.270 -0.351
ENSG00000245958 E031 3.1146980 0.0174874888 8.019741e-01 0.9488982474 4 119461852 119462191 340 + 0.575 0.609 0.155
ENSG00000245958 E032 24.1099620 0.0011630228 3.413538e-03 0.1051773041 4 119462896 119462979 84 + 1.496 1.293 -0.704
ENSG00000245958 E033 54.0019432 0.0006949974 2.567929e-07 0.0002106579 4 119479826 119480935 1110 + 1.543 1.799 0.872
ENSG00000245958 E034 12.1005072 0.0082376464 6.064736e-01 0.8782652284 4 119488294 119488545 252 + 1.067 1.113 0.167
ENSG00000245958 E035 1.4295496 0.0174199416 3.440602e-01   4 119488643 119488644 2 + 0.473 0.306 -0.948
ENSG00000245958 E036 6.7981369 0.0339017649 7.169204e-01 0.9209957931 4 119488645 119488717 73 + 0.912 0.851 -0.236
ENSG00000245958 E037 35.2164297 0.0008607009 2.706672e-01 0.6748313679 4 119493333 119493437 105 + 1.580 1.514 -0.227
ENSG00000245958 E038 0.1767706 0.0323415074 3.230114e-01   4 119494426 119494432 7 + 0.144 0.000 -13.918
ENSG00000245958 E039 36.8729166 0.0009489702 3.797414e-01 0.7599883063 4 119494433 119494523 91 + 1.589 1.537 -0.180
ENSG00000245958 E040 1.2930859 0.0124761549 3.926898e-01   4 119497662 119497810 149 + 0.252 0.403 0.960
ENSG00000245958 E041 30.5039350 0.0010625965 1.859532e-01 0.5867343475 4 119497811 119497903 93 + 1.533 1.448 -0.291
ENSG00000245958 E042 5.4558143 0.0888441176 3.382913e-01 0.7307226455 4 119497904 119498292 389 + 0.702 0.835 0.534
ENSG00000245958 E043 25.3489532 0.0013630652 2.822842e-01 0.6852917389 4 119499561 119499836 276 + 1.355 1.428 0.251
ENSG00000245958 E044 6.9247502 0.0072828681 6.346793e-01 0.8900141267 4 119499837 119499871 35 + 0.840 0.897 0.221
ENSG00000245958 E045 11.8705862 0.0030116771 7.016436e-01 0.9156711737 4 119499872 119500279 408 + 1.108 1.069 -0.144
ENSG00000245958 E046 8.0854774 0.0328328304 3.968230e-02 0.3130845140 4 119512351 119512372 22 + 1.105 0.834 -1.009
ENSG00000245958 E047 9.5855412 0.0417252863 1.963146e-03 0.0788250318 4 119512373 119512464 92 + 1.236 0.818 -1.541
ENSG00000245958 E048 9.6651627 0.0198655295 3.898855e-04 0.0309423054 4 119512813 119512920 108 + 1.233 0.819 -1.526
ENSG00000245958 E049 5.6967270 0.1342296033 4.943016e-02 0.3426629718 4 119512921 119512970 50 + 1.010 0.655 -1.390
ENSG00000245958 E050 6.4053997 0.0187915660 1.087587e-01 0.4733116663 4 119516973 119517105 133 + 0.696 0.923 0.896
ENSG00000245958 E051 0.8225277 0.0230671099 5.297766e-02   4 119519489 119519651 163 + 0.000 0.357 14.416
ENSG00000245958 E052 6.0036793 0.0258017919 3.377198e-01 0.7302183287 4 119528740 119528789 50 + 0.909 0.784 -0.485
ENSG00000245958 E053 3.8188457 0.0546785663 4.478569e-01 0.8024222898 4 119528790 119528867 78 + 0.575 0.725 0.642
ENSG00000245958 E054 1.4352415 0.0130455680 7.119265e-01   4 119543753 119543845 93 + 0.339 0.403 0.373
ENSG00000245958 E055 1.8066923 0.0101003887 1.319560e-01 0.5133055430 4 119547707 119547728 22 + 0.252 0.518 1.545
ENSG00000245958 E056 72.6874619 0.0038141937 2.088671e-03 0.0815007516 4 119548206 119550378 2173 + 1.751 1.900 0.502
ENSG00000245958 E057 13.2143223 0.0019755524 6.624832e-01 0.9013580611 4 119550379 119550443 65 + 1.108 1.147 0.139
ENSG00000245958 E058 12.6738229 0.0021957257 7.412560e-01 0.9295866347 4 119551888 119552025 138 + 1.146 1.114 -0.116