ENSG00000243970

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000431553 ENSG00000243970 HEK293_DMSO_6hA HEK293_OSMI2_6hA PPIEL transcribed_unprocessed_pseudogene processed_transcript 8.727698 14.40315 11.27516 1.399676 2.147575 -0.3529595 0.36951854 1.1643053 0.0000000 0.36248943 0.0000000 -6.87566367 0.040800000 0.08316667 0.00000000 -0.08316667 1.593734e-06 1.593734e-06 FALSE FALSE
ENST00000645296 ENSG00000243970 HEK293_DMSO_6hA HEK293_OSMI2_6hA PPIEL transcribed_unprocessed_pseudogene processed_transcript 8.727698 14.40315 11.27516 1.399676 2.147575 -0.3529595 0.46819779 1.1822977 0.2826021 0.12926322 0.2031335 -2.02673275 0.052791667 0.08263333 0.02056667 -0.06206667 2.371155e-01 1.593734e-06 TRUE FALSE
ENST00000647627 ENSG00000243970 HEK293_DMSO_6hA HEK293_OSMI2_6hA PPIEL transcribed_unprocessed_pseudogene processed_transcript 8.727698 14.40315 11.27516 1.399676 2.147575 -0.3529595 1.09222399 2.4218199 1.3095810 0.21040381 0.6327180 -0.88195654 0.120558333 0.16920000 0.10456667 -0.06463333 5.182926e-01 1.593734e-06   FALSE
ENST00000649325 ENSG00000243970 HEK293_DMSO_6hA HEK293_OSMI2_6hA PPIEL transcribed_unprocessed_pseudogene processed_transcript 8.727698 14.40315 11.27516 1.399676 2.147575 -0.3529595 0.94240085 1.8116667 1.2658507 0.05014214 0.3479524 -0.51379955 0.105350000 0.12753333 0.10963333 -0.01790000 8.074712e-01 1.593734e-06 TRUE FALSE
ENST00000687069 ENSG00000243970 HEK293_DMSO_6hA HEK293_OSMI2_6hA PPIEL transcribed_unprocessed_pseudogene processed_transcript 8.727698 14.40315 11.27516 1.399676 2.147575 -0.3529595 0.05938565 0.0000000 0.4750852 0.00000000 0.2884361 5.60016626 0.006583333 0.00000000 0.05266667 0.05266667 2.764097e-01 1.593734e-06 FALSE FALSE
ENST00000688421 ENSG00000243970 HEK293_DMSO_6hA HEK293_OSMI2_6hA PPIEL transcribed_unprocessed_pseudogene processed_transcript 8.727698 14.40315 11.27516 1.399676 2.147575 -0.3529595 0.58016134 0.5598389 0.4175751 0.28631317 0.4175751 -0.41437625 0.070520833 0.04316667 0.02683333 -0.01633333 7.472379e-01 1.593734e-06 FALSE FALSE
ENST00000692918 ENSG00000243970 HEK293_DMSO_6hA HEK293_OSMI2_6hA PPIEL transcribed_unprocessed_pseudogene processed_transcript 8.727698 14.40315 11.27516 1.399676 2.147575 -0.3529595 0.58060658 0.2941207 0.6304040 0.29412075 0.4583987 1.07433812 0.073687500 0.01710000 0.06786667 0.05076667 7.169365e-01 1.593734e-06 FALSE FALSE
MSTRG.907.29 ENSG00000243970 HEK293_DMSO_6hA HEK293_OSMI2_6hA PPIEL transcribed_unprocessed_pseudogene   8.727698 14.40315 11.27516 1.399676 2.147575 -0.3529595 2.17740257 3.4617128 3.3633122 0.62083441 0.5170087 -0.04148176 0.247362500 0.23676667 0.30203333 0.06526667 4.649513e-01 1.593734e-06   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000243970 E001 0.5297488 0.0212679669 0.365961908   1 39522280 39522282 3 - 0.245 0.102 -1.517
ENSG00000243970 E002 0.5297488 0.0212679669 0.365961908   1 39522283 39522286 4 - 0.245 0.102 -1.517
ENSG00000243970 E003 0.5297488 0.0212679669 0.365961908   1 39522287 39522287 1 - 0.245 0.102 -1.517
ENSG00000243970 E004 0.7065194 0.0192145009 0.168266476   1 39522288 39522299 12 - 0.331 0.102 -2.104
ENSG00000243970 E005 1.2296286 0.0166517042 0.904039771   1 39522300 39522313 14 - 0.330 0.314 -0.102
ENSG00000243970 E006 2.0365470 0.0162472848 0.272919644 0.67678071 1 39522314 39522325 12 - 0.330 0.530 1.066
ENSG00000243970 E007 3.8549423 0.0477898173 0.380883747 0.76064631 1 39522326 39522350 25 - 0.567 0.720 0.658
ENSG00000243970 E008 29.3499883 0.0102601637 0.488443849 0.82368638 1 39522351 39522471 121 - 1.420 1.485 0.225
ENSG00000243970 E009 37.4368433 0.0085907636 0.447790957 0.80240426 1 39522472 39522505 34 - 1.524 1.592 0.230
ENSG00000243970 E010 6.8281886 0.0268849045 0.206280267 0.61021218 1 39523558 39523561 4 - 0.958 0.800 -0.604
ENSG00000243970 E011 39.5807814 0.0008024463 0.180956731 0.58058703 1 39523562 39523697 136 - 1.531 1.619 0.299
ENSG00000243970 E012 26.4945684 0.0701012693 0.293442717 0.69426543 1 39523807 39523844 38 - 1.355 1.467 0.388
ENSG00000243970 E013 28.5835976 0.0229986756 0.295015670 0.69544836 1 39523845 39523896 52 - 1.400 1.488 0.306
ENSG00000243970 E014 60.3969354 0.0014098552 0.587378354 0.87019463 1 39523897 39524835 939 - 1.780 1.762 -0.062
ENSG00000243970 E015 41.8189587 0.0015357882 0.276313582 0.68005833 1 39524836 39525057 222 - 1.642 1.594 -0.166
ENSG00000243970 E016 18.9657998 0.0046469239 0.978183830 0.99484557 1 39525058 39525151 94 - 1.283 1.292 0.032
ENSG00000243970 E017 43.5142868 0.0007746807 0.108088026 0.47211914 1 39525152 39525685 534 - 1.568 1.666 0.334
ENSG00000243970 E018 27.1691704 0.0012050668 0.175917171 0.57412227 1 39525699 39525848 150 - 1.362 1.464 0.354
ENSG00000243970 E019 28.6483515 0.0301218126 0.857652589 0.96500912 1 39527617 39527829 213 - 1.459 1.458 -0.005
ENSG00000243970 E020 11.8360422 0.0023087190 0.034376034 0.29525829 1 39529016 39529054 39 - 0.934 1.162 0.835
ENSG00000243970 E021 49.9572350 0.0207647993 0.427197576 0.79045835 1 39529055 39529164 110 - 1.632 1.727 0.324
ENSG00000243970 E022 1.9272081 0.0756903125 0.219691594 0.62427976 1 39531838 39531896 59 - 0.572 0.315 -1.363
ENSG00000243970 E023 2.3398063 0.0086756452 0.355073589 0.74336879 1 39537191 39537343 153 - 0.401 0.563 0.808
ENSG00000243970 E024 0.9142451 0.0156375243 0.033221508   1 39541657 39541719 63 - 0.462 0.102 -2.836
ENSG00000243970 E025 39.9063157 0.0250572447 0.999491248 0.99988244 1 39541720 39541839 120 - 1.581 1.611 0.102
ENSG00000243970 E026 11.2936246 0.0026345404 0.478079293 0.81825727 1 39541840 39541841 2 - 1.020 1.103 0.299
ENSG00000243970 E027 39.4917913 0.0011205189 0.465307413 0.81132246 1 39545733 39545857 125 - 1.607 1.578 -0.098
ENSG00000243970 E028 40.0103913 0.0293730128 0.196693092 0.59995073 1 39545858 39546187 330 - 1.547 1.624 0.265
ENSG00000243970 E029 21.1481198 0.0016701681 0.986053247 0.99662034 1 39547579 39547608 30 - 1.317 1.326 0.030
ENSG00000243970 E030 20.1191825 0.0013754028 0.778639695 0.94196585 1 39547609 39547629 21 - 1.308 1.297 -0.038
ENSG00000243970 E031 16.1718552 0.0017997268 0.294865157 0.69527456 1 39547630 39547634 5 - 1.257 1.178 -0.280
ENSG00000243970 E032 15.8573135 0.0766764139 0.244367980 0.64976416 1 39547635 39547708 74 - 1.143 1.245 0.361
ENSG00000243970 E033 12.1702723 0.0389695164 0.182712048 0.58273247 1 39547709 39547749 41 - 1.000 1.152 0.551
ENSG00000243970 E034 79.7510748 0.0215412988 0.090010928 0.43855350 1 39547750 39548669 920 - 1.836 1.922 0.291
ENSG00000243970 E035 7.3393068 0.0067184324 0.866418723 0.96729915 1 39548670 39548682 13 - 0.893 0.926 0.124
ENSG00000243970 E036 13.1260478 0.0267391096 0.632192943 0.88886678 1 39548683 39548746 64 - 1.158 1.120 -0.137
ENSG00000243970 E037 16.0348030 0.0656417423 0.609582011 0.87977644 1 39548747 39548861 115 - 1.183 1.233 0.180
ENSG00000243970 E038 38.5886001 0.0016997137 0.131070441 0.51186925 1 39548862 39548951 90 - 1.620 1.543 -0.263
ENSG00000243970 E039 0.9545519 0.0163712209 0.649818289   1 39549790 39549896 107 - 0.330 0.254 -0.515
ENSG00000243970 E040 24.8474444 0.0011542707 0.957668029 0.99034804 1 39553118 39553144 27 - 1.389 1.396 0.022
ENSG00000243970 E041 39.6075318 0.0008906918 0.033445983 0.29223059 1 39554349 39554392 44 - 1.650 1.543 -0.362
ENSG00000243970 E042 2.5334989 0.0117411999 0.451396399 0.80431623 1 39556134 39556201 68 - 0.606 0.494 -0.516
ENSG00000243970 E043 26.3170354 0.0019840000 0.726224817 0.92437792 1 39556599 39556738 140 - 1.390 1.427 0.128
ENSG00000243970 E044 6.9558098 0.0045575785 0.845228845 0.96168706 1 39556739 39556740 2 - 0.850 0.883 0.126
ENSG00000243970 E045 23.7692948 0.0012529708 0.821232286 0.95483912 1 39557002 39557143 142 - 1.354 1.382 0.095
ENSG00000243970 E046 2.5145277 0.0405974881 0.848867310 0.96277277 1 39558584 39558637 54 - 0.512 0.563 0.238
ENSG00000243970 E047 6.5157875 0.0046203102 0.784867401 0.94370201 1 39558638 39558959 322 - 0.826 0.867 0.161
ENSG00000243970 E048 5.1018472 0.0107426758 0.415261236 0.78367523 1 39558960 39559215 256 - 0.682 0.800 0.480
ENSG00000243970 E049 48.5575682 0.0148763625 0.001417309 0.06604635 1 39559216 39559365 150 - 1.799 1.579 -0.745
ENSG00000243970 E050 29.9267935 0.0033710083 0.000246892 0.02329853 1 39559366 39559493 128 - 1.593 1.357 -0.811
ENSG00000243970 E051 15.7155115 0.0372185615 0.043602672 0.32533456 1 39559494 39559633 140 - 1.337 1.076 -0.926
ENSG00000243970 E052 7.9736064 0.0125143648 0.077504100 0.41244185 1 39559634 39559698 65 - 1.052 0.850 -0.755