ENSG00000240344

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000364629 ENSG00000240344 HEK293_DMSO_6hA HEK293_OSMI2_6hA PPIL3 protein_coding snRNA 25.25976 11.87042 11.34961 1.865484 1.66389 -0.06467256 2.0141461 2.2859918 3.5223745 1.3879670 2.34078113 0.62152079 0.09110417 0.2190000 0.26393333 0.04493333 0.99660576 0.01268334   FALSE
ENST00000392283 ENSG00000240344 HEK293_DMSO_6hA HEK293_OSMI2_6hA PPIL3 protein_coding protein_coding 25.25976 11.87042 11.34961 1.865484 1.66389 -0.06467256 5.1464676 2.1682243 1.5679936 0.5071839 0.44173359 -0.46506117 0.21177917 0.1781667 0.14476667 -0.03340000 0.75259409 0.01268334 FALSE TRUE
ENST00000463866 ENSG00000240344 HEK293_DMSO_6hA HEK293_OSMI2_6hA PPIL3 protein_coding retained_intron 25.25976 11.87042 11.34961 1.865484 1.66389 -0.06467256 0.6623365 1.6738158 0.3495845 0.5993581 0.05409986 -2.22733149 0.03481667 0.1327333 0.03200000 -0.10073333 0.01268334 0.01268334   FALSE
ENST00000465823 ENSG00000240344 HEK293_DMSO_6hA HEK293_OSMI2_6hA PPIL3 protein_coding processed_transcript 25.25976 11.87042 11.34961 1.865484 1.66389 -0.06467256 1.8606844 0.5553008 0.8786756 0.2915344 0.25940091 0.65263814 0.07296250 0.0464000 0.08893333 0.04253333 0.74957775 0.01268334   FALSE
MSTRG.19744.5 ENSG00000240344 HEK293_DMSO_6hA HEK293_OSMI2_6hA PPIL3 protein_coding   25.25976 11.87042 11.34961 1.865484 1.66389 -0.06467256 10.8516841 2.3294813 2.4797788 1.3670646 0.45718819 0.08982892 0.38735833 0.1857000 0.23106667 0.04536667 0.80174095 0.01268334 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000240344 E001 0.000000       2 200870907 200870955 49 -      
ENSG00000240344 E002 15.256560 0.0285272417 0.6992053251 0.91478821 2 200870956 200871151 196 - 1.237 1.182 -0.196
ENSG00000240344 E003 22.375083 0.0136591451 0.9031386497 0.97704065 2 200871152 200871212 61 - 1.370 1.353 -0.060
ENSG00000240344 E004 21.493967 0.0132319235 0.9670156827 0.99245346 2 200871213 200871229 17 - 1.348 1.342 -0.021
ENSG00000240344 E005 26.708674 0.0061428833 0.6354984444 0.89046030 2 200871230 200871266 37 - 1.423 1.450 0.096
ENSG00000240344 E006 47.072106 0.0008425354 0.2138875608 0.61845610 2 200871267 200871373 107 - 1.721 1.658 -0.214
ENSG00000240344 E007 63.082212 0.0012073372 0.3533304690 0.74210076 2 200871374 200871521 148 - 1.835 1.792 -0.146
ENSG00000240344 E008 34.419183 0.0016596656 0.3107691039 0.70868674 2 200876919 200876941 23 - 1.516 1.575 0.200
ENSG00000240344 E009 35.232597 0.0018059115 0.5438234640 0.85163102 2 200876942 200876963 22 - 1.543 1.578 0.119
ENSG00000240344 E010 50.470691 0.0007400885 0.2195429057 0.62419977 2 200876964 200877037 74 - 1.679 1.737 0.198
ENSG00000240344 E011 3.108618 0.0234888961 0.8559580537 0.96450008 2 200877497 200877604 108 - 0.585 0.615 0.131
ENSG00000240344 E012 25.514063 0.0011236308 0.0646818980 0.38351779 2 200881421 200881421 1 - 1.347 1.472 0.431
ENSG00000240344 E013 48.387667 0.0007412420 0.1303007763 0.51083589 2 200881422 200881488 67 - 1.649 1.723 0.252
ENSG00000240344 E014 10.613247 0.0242927143 0.0001461787 0.01692741 2 200881489 200881714 226 - 0.692 1.210 1.955
ENSG00000240344 E015 4.622688 0.1195082287 0.1146679076 0.48365883 2 200881715 200881821 107 - 0.546 0.842 1.242
ENSG00000240344 E016 33.504840 0.0009166235 0.1548676898 0.54631349 2 200882342 200882382 41 - 1.488 1.572 0.287
ENSG00000240344 E017 30.771383 0.0009464221 0.4943471090 0.82647185 2 200882383 200882435 53 - 1.478 1.519 0.142
ENSG00000240344 E018 5.650722 0.1545769045 0.8742297166 0.96958566 2 200884902 200885261 360 - 0.812 0.809 -0.014
ENSG00000240344 E019 6.053821 0.0067388537 0.3322404368 0.72634147 2 200885262 200885296 35 - 0.925 0.805 -0.462
ENSG00000240344 E020 5.182468 0.0044734999 0.1940901525 0.59655505 2 200885297 200885318 22 - 0.888 0.720 -0.660
ENSG00000240344 E021 5.627405 0.0042616203 0.0039164242 0.11191990 2 200885319 200885343 25 - 1.008 0.644 -1.432
ENSG00000240344 E022 5.268861 0.0138202264 0.0361544561 0.30109290 2 200885344 200885367 24 - 0.957 0.671 -1.130
ENSG00000240344 E023 2.506096 0.0080457797 0.0105028879 0.17743124 2 200885368 200885697 330 - 0.233 0.671 2.378
ENSG00000240344 E024 39.065422 0.0040147829 0.0380290439 0.30708810 2 200885698 200885772 75 - 1.673 1.553 -0.409
ENSG00000240344 E025 0.000000       2 200886914 200886982 69 -      
ENSG00000240344 E026 33.460733 0.0072969782 0.0236999546 0.25328052 2 200887613 200887683 71 - 1.622 1.466 -0.532
ENSG00000240344 E027 18.861698 0.0133421400 0.6579574846 0.89993213 2 200887684 200887685 2 - 1.323 1.281 -0.149
ENSG00000240344 E028 2.195026 0.0100132991 0.3495003439 0.73897452 2 200887686 200887687 2 - 0.584 0.432 -0.737
ENSG00000240344 E029 4.974873 0.1606934653 0.6688531295 0.90377998 2 200888294 200888579 286 - 0.804 0.775 -0.117
ENSG00000240344 E030 2.257080 0.0089522236 0.9043204817 0.97730957 2 200888949 200888955 7 - 0.495 0.514 0.094
ENSG00000240344 E031 26.374319 0.0011039762 0.6280014447 0.88699236 2 200888956 200889243 288 - 1.456 1.424 -0.113
ENSG00000240344 E032 3.735996 0.0060252203 0.9100716389 0.97851671 2 200889244 200889303 60 - 0.689 0.671 -0.077