ENSG00000236088

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000602539 ENSG00000236088 HEK293_DMSO_6hA HEK293_OSMI2_6hA COX10-DT lncRNA lncRNA 3.753065 3.808984 2.943981 0.7644511 0.3470603 -0.3705281 0.09118008 0.00000000 0.2618728 0.00000000 0.08193599 4.7648599 0.02348750 0.00000000 0.09360000 0.09360000 0.0057618009 0.0002032502   FALSE
ENST00000623598 ENSG00000236088 HEK293_DMSO_6hA HEK293_OSMI2_6hA COX10-DT lncRNA TEC 3.753065 3.808984 2.943981 0.7644511 0.3470603 -0.3705281 0.22905312 0.74928410 0.0000000 0.22864986 0.00000000 -6.2465679 0.08462500 0.21546667 0.00000000 -0.21546667 0.0002032502 0.0002032502   FALSE
ENST00000655970 ENSG00000236088 HEK293_DMSO_6hA HEK293_OSMI2_6hA COX10-DT lncRNA lncRNA 3.753065 3.808984 2.943981 0.7644511 0.3470603 -0.3705281 0.14952942 0.32911037 0.0000000 0.10629202 0.00000000 -5.0836830 0.04346250 0.09946667 0.00000000 -0.09946667 0.0189930206 0.0002032502   FALSE
ENST00000656963 ENSG00000236088 HEK293_DMSO_6hA HEK293_OSMI2_6hA COX10-DT lncRNA lncRNA 3.753065 3.808984 2.943981 0.7644511 0.3470603 -0.3705281 0.46494187 0.33664072 0.2446147 0.33664072 0.13473313 -0.4451252 0.10872500 0.06313333 0.07993333 0.01680000 0.7439617430 0.0002032502   FALSE
ENST00000659114 ENSG00000236088 HEK293_DMSO_6hA HEK293_OSMI2_6hA COX10-DT lncRNA lncRNA 3.753065 3.808984 2.943981 0.7644511 0.3470603 -0.3705281 0.24206960 0.17086140 0.1962399 0.05362490 0.01885770 0.1894390 0.05749167 0.04333333 0.06766667 0.02433333 0.7483774383 0.0002032502   FALSE
ENST00000661551 ENSG00000236088 HEK293_DMSO_6hA HEK293_OSMI2_6hA COX10-DT lncRNA lncRNA 3.753065 3.808984 2.943981 0.7644511 0.3470603 -0.3705281 1.21830252 1.35919846 0.8958744 0.47451007 0.13659013 -0.5959487 0.31234583 0.33996667 0.31110000 -0.02886667 0.8897317971 0.0002032502   FALSE
ENST00000662986 ENSG00000236088 HEK293_DMSO_6hA HEK293_OSMI2_6hA COX10-DT lncRNA lncRNA 3.753065 3.808984 2.943981 0.7644511 0.3470603 -0.3705281 0.26154196 0.43421004 0.2782819 0.14130303 0.18308226 -0.6237617 0.07328333 0.11070000 0.08666667 -0.02403333 0.7995592860 0.0002032502   FALSE
ENST00000664394 ENSG00000236088 HEK293_DMSO_6hA HEK293_OSMI2_6hA COX10-DT lncRNA lncRNA 3.753065 3.808984 2.943981 0.7644511 0.3470603 -0.3705281 0.14652160 0.04764403 0.3168549 0.04764403 0.26413726 2.5034071 0.04067917 0.01626667 0.11520000 0.09893333 0.7267129694 0.0002032502   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000236088 E001 0.2892872 0.027442404 0.142525696   17 13755574 13756729 1156 - 0.236 0.000 -11.243
ENSG00000236088 E002 0.2920894 0.026974712 0.852994408   17 13776373 13776603 231 - 0.134 0.107 -0.375
ENSG00000236088 E003 0.1125166 0.032888596 0.385893297   17 13776604 13776627 24 - 0.134 0.000 -12.722
ENSG00000236088 E004 0.1125166 0.032888596 0.385893297   17 13776628 13776631 4 - 0.134 0.000 -12.722
ENSG00000236088 E005 0.4481873 0.024441170 0.424249512   17 13776632 13776660 29 - 0.236 0.106 -1.379
ENSG00000236088 E006 2.6070247 0.039587170 0.082233822 0.42249807 17 13776661 13776826 166 - 0.722 0.426 -1.360
ENSG00000236088 E007 1.8376109 0.014156836 0.002853228 0.09574840 17 13776827 13776831 5 - 0.695 0.192 -2.832
ENSG00000236088 E008 3.2114006 0.034273853 0.205000833 0.60862627 17 13776832 13776879 48 - 0.750 0.544 -0.890
ENSG00000236088 E009 11.7209361 0.013378129 0.554233429 0.85559945 17 13776880 13777176 297 - 1.144 1.073 -0.256
ENSG00000236088 E010 8.8736835 0.024746711 0.939464070 0.98575899 17 13777177 13777306 130 - 0.986 0.984 -0.010
ENSG00000236088 E011 4.9895717 0.005111476 0.373622062 0.75557186 17 13777307 13777349 43 - 0.832 0.713 -0.473
ENSG00000236088 E012 2.5152172 0.010069371 0.039208660 0.31158662 17 13777476 13777658 183 - 0.318 0.664 1.740
ENSG00000236088 E013 1.0687058 0.014402148 0.137261008   17 13790269 13790313 45 - 0.448 0.192 -1.703
ENSG00000236088 E014 4.7957030 0.062086340 0.942147912 0.98644129 17 13790314 13793577 3264 - 0.758 0.756 -0.004
ENSG00000236088 E015 0.1125166 0.032888596 0.385893297   17 13865079 13865266 188 - 0.134 0.000 -12.722
ENSG00000236088 E016 1.6001825 0.057667646 0.348497275   17 13880302 13880371 70 - 0.502 0.325 -0.972
ENSG00000236088 E017 1.7089438 0.305526630 0.258736187 0.66431402 17 13892725 13892839 115 - 0.567 0.264 -1.685
ENSG00000236088 E018 0.6545095 0.090049467 0.226430653   17 13892840 13892842 3 - 0.320 0.107 -1.968
ENSG00000236088 E019 0.2669773 0.027442404 0.846553581   17 13898609 13898732 124 - 0.134 0.106 -0.377
ENSG00000236088 E020 0.4387454 0.024441170 0.735517746   17 14028676 14028709 34 - 0.134 0.192 0.624
ENSG00000236088 E021 1.1667781 0.017262643 0.720257577   17 14028710 14028740 31 - 0.388 0.324 -0.375
ENSG00000236088 E022 1.1667781 0.017262643 0.720257577   17 14028741 14028765 25 - 0.388 0.324 -0.375
ENSG00000236088 E023 6.2528424 0.022512558 0.475403371 0.81689478 17 14028766 14028890 125 - 0.785 0.884 0.386
ENSG00000236088 E024 4.2303861 0.007243663 0.631619986 0.88869788 17 14028891 14028896 6 - 0.665 0.736 0.295
ENSG00000236088 E025 5.5045273 0.004374308 0.197802592 0.60093121 17 14028897 14028901 5 - 0.697 0.869 0.683
ENSG00000236088 E026 22.4982792 0.009327866 0.045539484 0.33165103 17 14028902 14029291 390 - 1.257 1.419 0.566
ENSG00000236088 E027 13.0014642 0.132676730 0.843905909 0.96127088 17 14029292 14029629 338 - 1.103 1.153 0.182
ENSG00000236088 E028 60.9817051 0.001600040 0.027539610 0.26918961 17 14029630 14030571 942 - 1.727 1.826 0.334
ENSG00000236088 E029 15.9754201 0.001965685 0.107678882 0.47120729 17 14030572 14030756 185 - 1.135 1.274 0.490
ENSG00000236088 E030 7.7053569 0.019316472 0.429494386 0.79160783 17 14030757 14030788 32 - 0.987 0.898 -0.334
ENSG00000236088 E031 18.7281378 0.001601796 0.144618947 0.53166051 17 14030789 14031093 305 - 1.356 1.247 -0.380
ENSG00000236088 E032 26.9521732 0.002129066 0.588174733 0.87047443 17 14031094 14031639 546 - 1.420 1.455 0.120
ENSG00000236088 E033 78.7840355 0.005869566 0.362576806 0.74882827 17 14031640 14033551 1912 - 1.872 1.915 0.147
ENSG00000236088 E034 17.7893364 0.005149414 0.615839680 0.88248165 17 14033552 14033661 110 - 1.253 1.298 0.156
ENSG00000236088 E035 19.6323039 0.016240997 0.961188001 0.99107116 17 14033662 14033939 278 - 1.303 1.324 0.073
ENSG00000236088 E036 13.3642012 0.013186755 0.649738313 0.89626078 17 14033940 14034007 68 - 1.178 1.145 -0.117
ENSG00000236088 E037 40.4896715 0.005538730 0.035982188 0.30063464 17 14034008 14034416 409 - 1.679 1.561 -0.402
ENSG00000236088 E038 14.8879762 0.004229325 0.001650657 0.07201915 17 14069272 14069495 224 - 1.329 1.052 -0.983