ENSG00000232956

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000578968 ENSG00000232956 HEK293_DMSO_6hA HEK293_OSMI2_6hA SNHG15 lncRNA lncRNA 90.20389 85.68258 101.9009 7.055808 12.18326 0.250066 58.463846 43.68213 75.514264 4.414779 16.771763 0.7895669 0.62937083 0.5084667 0.72100000 0.21253333 0.1479246 0.0029639   FALSE
ENST00000582727 ENSG00000232956 HEK293_DMSO_6hA HEK293_OSMI2_6hA SNHG15 lncRNA lncRNA 90.20389 85.68258 101.9009 7.055808 12.18326 0.250066 3.401550 0.00000 4.278793 0.000000 2.976995 8.7444278 0.04139167 0.0000000 0.05110000 0.05110000 0.4434801 0.0029639   FALSE
ENST00000667119 ENSG00000232956 HEK293_DMSO_6hA HEK293_OSMI2_6hA SNHG15 lncRNA lncRNA 90.20389 85.68258 101.9009 7.055808 12.18326 0.250066 8.152723 19.59605 6.050227 1.154288 1.901514 -1.6938549 0.09847500 0.2318667 0.06586667 -0.16600000 0.0029639 0.0029639   FALSE
ENST00000667823 ENSG00000232956 HEK293_DMSO_6hA HEK293_OSMI2_6hA SNHG15 lncRNA lncRNA 90.20389 85.68258 101.9009 7.055808 12.18326 0.250066 4.990981 10.72360 3.716609 1.395042 2.462868 -1.5261988 0.05615417 0.1242333 0.03186667 -0.09236667 0.6175983 0.0029639   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000232956 E001 0.0000000       7 44983019 44983022 4 -      
ENSG00000232956 E002 0.9969716 0.016648976 0.9001801780   7 44983023 44983024 2 - 0.287 0.294 0.049
ENSG00000232956 E003 5.9063197 0.013693845 0.1457077943 0.53328197 7 44983025 44983033 9 - 0.911 0.766 -0.564
ENSG00000232956 E004 8.2143377 0.024044465 0.0843071884 0.42634071 7 44983034 44983037 4 - 1.050 0.873 -0.664
ENSG00000232956 E005 9.0875620 0.003373211 0.0311558597 0.28399743 7 44983038 44983038 1 - 1.087 0.908 -0.661
ENSG00000232956 E006 129.2648815 0.002329550 0.3652998124 0.75045076 7 44983039 44983084 46 - 2.098 2.125 0.091
ENSG00000232956 E007 132.3761534 0.002477402 0.4049402650 0.77686836 7 44983085 44983085 1 - 2.106 2.137 0.101
ENSG00000232956 E008 277.2966455 0.006689011 0.3798234703 0.76003900 7 44983086 44983136 51 - 2.429 2.456 0.091
ENSG00000232956 E009 1165.2228757 0.006899587 0.2675422035 0.67196373 7 44983137 44983322 186 - 3.052 3.079 0.088
ENSG00000232956 E010 514.3409335 0.096555648 0.0139722193 0.20261858 7 44983323 44983821 499 - 2.509 2.840 1.102
ENSG00000232956 E011 643.7812586 0.007379039 0.1047790761 0.46630579 7 44983822 44983846 25 - 2.811 2.807 -0.014
ENSG00000232956 E012 1257.0875117 0.008283225 0.0306115864 0.28184328 7 44983847 44983957 111 - 3.110 3.089 -0.071
ENSG00000232956 E013 1040.3975321 0.007094985 0.0125733242 0.19350915 7 44983958 44984046 89 - 3.033 3.002 -0.103
ENSG00000232956 E014 459.8982657 0.061418171 0.0111505639 0.18271826 7 44984047 44984356 310 - 2.482 2.781 0.994
ENSG00000232956 E015 821.3164514 0.009260389 0.0371950922 0.30459904 7 44984357 44984426 70 - 2.930 2.900 -0.097
ENSG00000232956 E016 713.3305111 0.170487391 0.0431198009 0.32399205 7 44984427 44985377 951 - 2.657 2.979 1.071
ENSG00000232956 E017 365.2031324 0.163520519 0.0528307193 0.35232315 7 44985378 44985881 504 - 2.375 2.685 1.030
ENSG00000232956 E018 215.4568818 0.071565278 0.0577644104 0.36549720 7 44985882 44986020 139 - 2.195 2.432 0.791
ENSG00000232956 E019 770.3025854 0.005473793 0.0007339236 0.04551562 7 44986021 44986097 77 - 2.915 2.858 -0.190
ENSG00000232956 E020 66.7405698 0.095887052 0.2500985163 0.65584617 7 44986098 44986524 427 - 1.737 1.898 0.541
ENSG00000232956 E021 652.2276174 0.006268083 0.0038637641 0.11115127 7 44986525 44986961 437 - 2.840 2.790 -0.165