ENSG00000229043

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000413706 ENSG00000229043 HEK293_DMSO_6hA HEK293_OSMI2_6hA ZFAND2A-DT lncRNA lncRNA 3.824227 3.524742 5.316989 0.09765591 0.5664368 0.5917152 0.1420919 0.00000000 0.3671579 0.00000000 0.36715787 5.2370966 0.04125417 0.000000000 0.05770000 0.057700000 0.7863376744 2.48143e-05   FALSE
ENST00000423008 ENSG00000229043 HEK293_DMSO_6hA HEK293_OSMI2_6hA ZFAND2A-DT lncRNA lncRNA 3.824227 3.524742 5.316989 0.09765591 0.5664368 0.5917152 0.4429773 0.56067488 0.7393337 0.08979577 0.09226727 0.3929393 0.11549583 0.159933333 0.14066667 -0.019266667 0.8863574499 2.48143e-05   FALSE
ENST00000660500 ENSG00000229043 HEK293_DMSO_6hA HEK293_OSMI2_6hA ZFAND2A-DT lncRNA lncRNA 3.824227 3.524742 5.316989 0.09765591 0.5664368 0.5917152 0.3625762 0.65957670 0.5023329 0.04109287 0.11552460 -0.3861677 0.10789167 0.187066667 0.10123333 -0.085833333 0.4969926824 2.48143e-05   FALSE
ENST00000662926 ENSG00000229043 HEK293_DMSO_6hA HEK293_OSMI2_6hA ZFAND2A-DT lncRNA lncRNA 3.824227 3.524742 5.316989 0.09765591 0.5664368 0.5917152 0.2271347 0.11245685 0.2633979 0.02806407 0.02545124 1.1587288 0.05450000 0.032300000 0.05166667 0.019366667 0.7589368061 2.48143e-05   FALSE
MSTRG.29377.1 ENSG00000229043 HEK293_DMSO_6hA HEK293_OSMI2_6hA ZFAND2A-DT lncRNA   3.824227 3.524742 5.316989 0.09765591 0.5664368 0.5917152 0.5390883 0.55773341 0.7059709 0.03286486 0.15541674 0.3346874 0.13927083 0.158066667 0.13560000 -0.022466667 0.8489373991 2.48143e-05   FALSE
MSTRG.29377.2 ENSG00000229043 HEK293_DMSO_6hA HEK293_OSMI2_6hA ZFAND2A-DT lncRNA   3.824227 3.524742 5.316989 0.09765591 0.5664368 0.5917152 0.2018010 0.01796221 0.3080618 0.01796221 0.09162266 3.5077570 0.04929167 0.004866667 0.05643333 0.051566667 0.1465148455 2.48143e-05   FALSE
MSTRG.29377.4 ENSG00000229043 HEK293_DMSO_6hA HEK293_OSMI2_6hA ZFAND2A-DT lncRNA   3.824227 3.524742 5.316989 0.09765591 0.5664368 0.5917152 0.2990840 0.21503158 0.2546416 0.21503158 0.25464160 0.2339124 0.08449167 0.064300000 0.04003333 -0.024266667 0.9910759774 2.48143e-05   FALSE
MSTRG.29377.5 ENSG00000229043 HEK293_DMSO_6hA HEK293_OSMI2_6hA ZFAND2A-DT lncRNA   3.824227 3.524742 5.316989 0.09765591 0.5664368 0.5917152 0.6204785 0.00000000 1.0934132 0.00000000 0.41905370 6.7858294 0.14959167 0.000000000 0.20720000 0.207200000 0.0000248143 2.48143e-05   FALSE
MSTRG.29377.6 ENSG00000229043 HEK293_DMSO_6hA HEK293_OSMI2_6hA ZFAND2A-DT lncRNA   3.824227 3.524742 5.316989 0.09765591 0.5664368 0.5917152 0.2831793 0.67480268 0.0000000 0.38138604 0.00000000 -6.0976164 0.07695000 0.187700000 0.00000000 -0.187700000 0.2141578107 2.48143e-05   FALSE
MSTRG.29377.9 ENSG00000229043 HEK293_DMSO_6hA HEK293_OSMI2_6hA ZFAND2A-DT lncRNA   3.824227 3.524742 5.316989 0.09765591 0.5664368 0.5917152 0.6814533 0.68223085 1.0371431 0.28584041 0.27543800 0.5971335 0.17338333 0.193666667 0.19920000 0.005533333 0.9612258798 2.48143e-05   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000229043 E001 0.1544607 0.038257757 0.3701991911   7 1160315 1160358 44 + 0.000 0.140 8.646
ENSG00000229043 E002 2.2662614 0.035508991 0.1967807591 0.60000263 7 1160359 1160373 15 + 0.409 0.646 1.133
ENSG00000229043 E003 3.0238457 0.039138145 0.2924908120 0.69340563 7 1160374 1160374 1 + 0.523 0.716 0.846
ENSG00000229043 E004 8.4579475 0.037301889 0.8326493662 0.95780098 7 1160375 1160431 57 + 0.966 1.006 0.149
ENSG00000229043 E005 14.8077760 0.004159667 0.4222193867 0.78745291 7 1160432 1160471 40 + 1.225 1.179 -0.163
ENSG00000229043 E006 17.1915810 0.020112776 0.1924147961 0.59446759 7 1160472 1160493 22 + 1.309 1.201 -0.382
ENSG00000229043 E007 30.7586922 0.012739096 0.0327522941 0.29007430 7 1160494 1160580 87 + 1.563 1.418 -0.499
ENSG00000229043 E008 22.9445354 0.006492056 0.0189752410 0.23070996 7 1160581 1160590 10 + 1.443 1.285 -0.550
ENSG00000229043 E009 21.3762827 0.001621244 0.0080518730 0.15669608 7 1160591 1160595 5 + 1.420 1.249 -0.595
ENSG00000229043 E010 23.0314285 0.001558213 0.0046479335 0.12244903 7 1160596 1160623 28 + 1.453 1.276 -0.615
ENSG00000229043 E011 29.8357486 0.017766484 0.0005662045 0.03888321 7 1160624 1162351 1728 + 1.310 1.634 1.115
ENSG00000229043 E012 62.1028896 0.008405660 0.1152151797 0.48492710 7 1162352 1162543 192 + 1.824 1.762 -0.209
ENSG00000229043 E013 8.6185324 0.030417209 0.2655659755 0.67040420 7 1162544 1162634 91 + 0.893 1.069 0.654
ENSG00000229043 E014 8.3773779 0.003311541 0.8844337918 0.97231767 7 1162635 1162684 50 + 0.963 0.972 0.035
ENSG00000229043 E015 16.6495123 0.001908338 0.9517944551 0.98875591 7 1162685 1162728 44 + 1.226 1.259 0.115
ENSG00000229043 E016 17.4309947 0.001947191 0.1728650319 0.57033738 7 1162729 1162961 233 + 1.198 1.334 0.477
ENSG00000229043 E017 35.5464460 0.004130535 0.5202317948 0.84017588 7 1162962 1163207 246 + 1.570 1.557 -0.044
ENSG00000229043 E018 2.7649942 0.007243635 0.3990753331 0.77269553 7 1163208 1163217 10 + 0.493 0.646 0.698
ENSG00000229043 E019 3.4923128 0.006167466 0.0290293051 0.27580621 7 1163218 1163342 125 + 0.455 0.801 1.527
ENSG00000229043 E020 3.6143587 0.102928590 0.2507970746 0.65660777 7 1163343 1163451 109 + 0.536 0.772 1.015
ENSG00000229043 E021 19.8506741 0.028405446 0.6261707029 0.88651477 7 1163452 1163495 44 + 1.271 1.349 0.271
ENSG00000229043 E022 164.1441845 0.027959012 0.2856029816 0.68789162 7 1164161 1165607 1447 + 2.169 2.263 0.314