ENSG00000227372

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000452079 ENSG00000227372 HEK293_DMSO_6hA HEK293_OSMI2_6hA TP73-AS1 transcribed_unitary_pseudogene processed_transcript 24.0652 26.78648 33.32978 0.8985759 0.8220235 0.3152011 4.657248 6.323363 5.512848 0.28853813 0.4159501 -0.19755937 0.20107500 0.23673333 0.16616667 -0.070566667 0.25156200 0.02484199 TRUE TRUE
ENST00000624167 ENSG00000227372 HEK293_DMSO_6hA HEK293_OSMI2_6hA TP73-AS1 transcribed_unitary_pseudogene processed_transcript 24.0652 26.78648 33.32978 0.8985759 0.8220235 0.3152011 1.586535 2.051365 2.369796 0.16324479 1.1997396 0.20723815 0.05812500 0.07633333 0.07070000 -0.005633333 0.81430207 0.02484199   FALSE
ENST00000647817 ENSG00000227372 HEK293_DMSO_6hA HEK293_OSMI2_6hA TP73-AS1 transcribed_unitary_pseudogene processed_transcript 24.0652 26.78648 33.32978 0.8985759 0.8220235 0.3152011 2.006722 2.613050 2.955788 0.03779357 0.2694341 0.17717048 0.08409167 0.09783333 0.08903333 -0.008800000 0.82963709 0.02484199 TRUE TRUE
ENST00000648270 ENSG00000227372 HEK293_DMSO_6hA HEK293_OSMI2_6hA TP73-AS1 transcribed_unitary_pseudogene processed_transcript 24.0652 26.78648 33.32978 0.8985759 0.8220235 0.3152011 2.558023 2.461800 2.307263 0.70896301 1.2109441 -0.09314003 0.10516667 0.09270000 0.07063333 -0.022066667 0.77214043 0.02484199 TRUE FALSE
ENST00000648600 ENSG00000227372 HEK293_DMSO_6hA HEK293_OSMI2_6hA TP73-AS1 transcribed_unitary_pseudogene processed_transcript 24.0652 26.78648 33.32978 0.8985759 0.8220235 0.3152011 3.998096 1.375643 6.359180 0.93734610 1.1375684 2.20055158 0.16626667 0.05250000 0.18963333 0.137133333 0.59400080 0.02484199 TRUE TRUE
ENST00000649123 ENSG00000227372 HEK293_DMSO_6hA HEK293_OSMI2_6hA TP73-AS1 transcribed_unitary_pseudogene processed_transcript 24.0652 26.78648 33.32978 0.8985759 0.8220235 0.3152011 1.113188 3.338020 1.255813 0.39710237 0.4095620 -1.40324316 0.04415833 0.12510000 0.03823333 -0.086866667 0.02484199 0.02484199 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000227372 E001 0.1767706 0.0335195068 0.5073503020   1 3735511 3735542 32 - 0.116 0.000 -9.681
ENSG00000227372 E002 0.1544607 0.0359213578 0.4674075424   1 3735601 3735610 10 - 0.000 0.123 12.127
ENSG00000227372 E003 0.6155160 0.0193874923 0.9566633542   1 3735611 3735624 14 - 0.208 0.219 0.098
ENSG00000227372 E004 0.6155160 0.0193874923 0.9566633542   1 3735625 3735649 25 - 0.208 0.219 0.098
ENSG00000227372 E005 10.3796584 0.0023957443 0.0066732811 0.14404360 1 3735650 3735685 36 - 1.170 0.897 -1.002
ENSG00000227372 E006 15.5586303 0.0019287935 0.0663315566 0.38742048 1 3735686 3735763 78 - 1.281 1.129 -0.538
ENSG00000227372 E007 55.8412884 0.0005076041 0.9072564670 0.97805456 1 3735764 3735983 220 - 1.745 1.756 0.040
ENSG00000227372 E008 48.9112694 0.0006086115 0.4704399601 0.81405639 1 3735984 3736056 73 - 1.669 1.712 0.145
ENSG00000227372 E009 61.9719598 0.0006999872 0.0233378033 0.25166766 1 3736057 3736174 118 - 1.737 1.846 0.369
ENSG00000227372 E010 34.0098479 0.0106564509 0.3098649923 0.70805469 1 3736175 3736192 18 - 1.500 1.586 0.294
ENSG00000227372 E011 92.7531984 0.0057319331 0.1528416307 0.54324640 1 3736193 3736407 215 - 1.929 2.007 0.265
ENSG00000227372 E012 41.6285135 0.0006755007 0.8196443682 0.95445710 1 3736408 3736448 41 - 1.614 1.633 0.064
ENSG00000227372 E013 41.0487431 0.0041938491 0.6474961158 0.89548082 1 3736449 3736481 33 - 1.596 1.634 0.129
ENSG00000227372 E014 32.5841633 0.0035210589 0.5903756272 0.87156006 1 3736482 3736482 1 - 1.493 1.538 0.153
ENSG00000227372 E015 62.4915303 0.0004529911 0.0588640321 0.36861169 1 3736483 3736533 51 - 1.747 1.838 0.307
ENSG00000227372 E016 55.0787462 0.0004980893 0.0813798065 0.42066838 1 3736534 3736558 25 - 1.697 1.785 0.300
ENSG00000227372 E017 63.0874379 0.0004678643 0.2969501464 0.69720468 1 3736559 3736758 200 - 1.773 1.825 0.178
ENSG00000227372 E018 41.9787854 0.0007367109 0.4340526289 0.79397657 1 3736759 3736925 167 - 1.605 1.653 0.164
ENSG00000227372 E019 81.1759978 0.0009533283 0.0694255571 0.39432328 1 3736926 3737103 178 - 1.869 1.949 0.268
ENSG00000227372 E020 33.0951694 0.0008860827 0.0620959700 0.37723581 1 3737104 3737142 39 - 1.465 1.584 0.407
ENSG00000227372 E021 24.6099150 0.0011452901 0.0581729878 0.36683871 1 3737143 3737148 6 - 1.327 1.465 0.479
ENSG00000227372 E022 31.4974925 0.0009377453 0.1820054773 0.58201365 1 3737149 3737165 17 - 1.465 1.553 0.303
ENSG00000227372 E023 38.1293201 0.0011405707 0.2042319213 0.60816323 1 3737166 3737192 27 - 1.551 1.630 0.268
ENSG00000227372 E024 40.5595053 0.0017722709 0.7228777459 0.92315298 1 3737193 3737205 13 - 1.607 1.633 0.089
ENSG00000227372 E025 38.8195157 0.0027807138 0.6938409220 0.91321280 1 3737206 3737211 6 - 1.587 1.616 0.101
ENSG00000227372 E026 137.6728912 0.0068976724 0.9805854380 0.99529127 1 3737212 3737337 126 - 2.139 2.146 0.024
ENSG00000227372 E027 268.5982488 0.0064812317 0.9155123041 0.97982102 1 3737338 3737528 191 - 2.424 2.437 0.043
ENSG00000227372 E028 120.4981652 0.0016410421 0.6627453328 0.90139026 1 3737529 3737538 10 - 2.088 2.079 -0.032
ENSG00000227372 E029 165.7764004 0.0007987013 0.3162786759 0.71341369 1 3737539 3737593 55 - 2.234 2.210 -0.080
ENSG00000227372 E030 277.7754214 0.0005819705 0.6332178189 0.88927861 1 3737594 3737780 187 - 2.445 2.440 -0.015
ENSG00000227372 E031 165.1155191 0.0001919014 0.1707730980 0.56802637 1 3737781 3737854 74 - 2.232 2.201 -0.104
ENSG00000227372 E032 265.7356556 0.0001632831 0.9134939344 0.97934852 1 3737855 3738074 220 - 2.419 2.423 0.013
ENSG00000227372 E033 261.5995389 0.0001775685 0.9949263343 0.99862784 1 3738075 3738222 148 - 2.413 2.419 0.020
ENSG00000227372 E034 332.0477579 0.0009900772 0.8582254715 0.96520409 1 3738223 3738433 211 - 2.518 2.521 0.008
ENSG00000227372 E035 116.3892704 0.0004393523 0.1148374927 0.48400455 1 3738434 3738446 13 - 2.087 2.041 -0.153
ENSG00000227372 E036 162.2367753 0.0019319365 0.0430758742 0.32383069 1 3738447 3738513 67 - 2.238 2.176 -0.206
ENSG00000227372 E037 275.2466618 0.0197291100 0.0532320236 0.35347728 1 3738514 3739058 545 - 2.376 2.494 0.394
ENSG00000227372 E038 90.0723804 0.0241990208 0.0980845894 0.45370756 1 3739059 3739216 158 - 1.892 2.012 0.404
ENSG00000227372 E039 31.1560844 0.0380934688 0.0950644116 0.44831887 1 3739217 3739227 11 - 1.409 1.580 0.585
ENSG00000227372 E040 37.9751962 0.0410063319 0.1877185185 0.58887023 1 3739228 3739299 72 - 1.519 1.648 0.439
ENSG00000227372 E041 14.4308365 0.0064216769 0.1119982183 0.47930671 1 3739300 3739335 36 - 1.092 1.249 0.561
ENSG00000227372 E042 4.3443266 0.0084471088 0.2077142456 0.61165227 1 3739336 3739371 36 - 0.610 0.796 0.775
ENSG00000227372 E043 7.7713747 0.1852643575 0.8088363978 0.95108370 1 3739372 3739407 36 - 0.882 0.996 0.431
ENSG00000227372 E044 8.0530070 0.0032395201 0.1982310002 0.60132239 1 3739408 3739457 50 - 0.871 1.021 0.562
ENSG00000227372 E045 17.3772574 0.0016042832 0.0936236196 0.44524059 1 3739458 3739515 58 - 1.179 1.322 0.505
ENSG00000227372 E046 18.7946206 0.0014398966 0.1742760564 0.57201084 1 3739516 3739551 36 - 1.229 1.342 0.397
ENSG00000227372 E047 19.9766622 0.0012798179 0.0099975544 0.17338407 1 3739552 3739587 36 - 1.204 1.408 0.712
ENSG00000227372 E048 18.9630064 0.0015185638 0.1050373628 0.46683930 1 3739588 3739623 36 - 1.229 1.361 0.464
ENSG00000227372 E049 26.0565681 0.0011242691 0.0439413447 0.32636261 1 3739624 3739659 36 - 1.351 1.494 0.492
ENSG00000227372 E050 22.6511588 0.0036974916 0.6536612237 0.89797675 1 3739660 3739695 36 - 1.347 1.385 0.134
ENSG00000227372 E051 20.1152007 0.0358948145 0.8929990381 0.97441117 1 3739696 3739704 9 - 1.334 1.301 -0.115
ENSG00000227372 E052 47.6821679 0.0285111804 0.3730795229 0.75532120 1 3739705 3739799 95 - 1.649 1.717 0.229
ENSG00000227372 E053 36.4096989 0.0572815843 0.0748339263 0.40659219 1 3739800 3739835 36 - 1.442 1.659 0.744
ENSG00000227372 E054 31.0454292 0.0009906800 0.0030716339 0.09981336 1 3739836 3739847 12 - 1.391 1.584 0.663
ENSG00000227372 E055 32.6184992 0.0147498846 0.0113551584 0.18436523 1 3739848 3739907 60 - 1.397 1.613 0.740
ENSG00000227372 E056 26.6898333 0.0097229708 0.0211988194 0.24142498 1 3739908 3739943 36 - 1.330 1.520 0.656
ENSG00000227372 E057 23.5867292 0.0017295816 0.0474832526 0.33716110 1 3739944 3739979 36 - 1.308 1.455 0.512
ENSG00000227372 E058 25.0618065 0.0134625381 0.1491144677 0.53818329 1 3739980 3739988 9 - 1.337 1.467 0.449
ENSG00000227372 E059 42.2773092 0.0119467488 0.0196648621 0.23400483 1 3739989 3740039 51 - 1.534 1.707 0.592
ENSG00000227372 E060 50.2428266 0.0071501989 0.0390339804 0.31075099 1 3740040 3740111 72 - 1.628 1.766 0.468
ENSG00000227372 E061 33.6359715 0.0452698056 0.0238006438 0.25368079 1 3740112 3740123 12 - 1.391 1.641 0.856
ENSG00000227372 E062 36.8760183 0.0325361515 0.1653568288 0.56098922 1 3740124 3740136 13 - 1.497 1.640 0.488
ENSG00000227372 E063 39.0874331 0.0008008361 0.0162325685 0.21603748 1 3740137 3740159 23 - 1.521 1.662 0.481
ENSG00000227372 E064 64.5277988 0.0193417624 0.2581803224 0.66386839 1 3740160 3740232 73 - 1.772 1.852 0.270
ENSG00000227372 E065 145.5116238 0.0028029767 0.0141686781 0.20384420 1 3740233 3740274 42 - 2.204 2.120 -0.283
ENSG00000227372 E066 221.3717746 0.0037246330 0.1679444388 0.56452792 1 3740275 3740387 113 - 2.366 2.325 -0.136
ENSG00000227372 E067 16.1431490 0.0176299474 0.2940998556 0.69473539 1 3740388 3741219 832 - 1.165 1.280 0.408
ENSG00000227372 E068 6.6481828 0.0037476529 0.4401635371 0.79791559 1 3741220 3741373 154 - 0.833 0.932 0.375
ENSG00000227372 E069 22.0872760 0.0054835413 0.1781978439 0.57710304 1 3741374 3742429 1056 - 1.295 1.409 0.393
ENSG00000227372 E070 18.2437698 0.0015909745 0.5286869450 0.84435113 1 3742430 3742517 88 - 1.245 1.301 0.199
ENSG00000227372 E071 6.4492068 0.0583201919 0.4749829135 0.81672851 1 3742518 3742803 286 - 0.799 0.916 0.453
ENSG00000227372 E072 206.4044919 0.0001660289 0.0567452146 0.36307165 1 3742804 3742911 108 - 2.333 2.293 -0.134
ENSG00000227372 E073 89.5232438 0.0003748658 0.0298837104 0.27909597 1 3742912 3742957 46 - 1.990 1.916 -0.252
ENSG00000227372 E074 39.1323250 0.0007349874 0.1131645279 0.48118613 1 3742958 3742960 3 - 1.639 1.557 -0.280
ENSG00000227372 E075 9.2641692 0.0700066565 0.6845414201 0.90982681 1 3742961 3742983 23 - 1.037 0.995 -0.156
ENSG00000227372 E076 211.5823297 0.0001577559 0.0129637161 0.19598617 1 3743061 3743190 130 - 2.350 2.296 -0.180
ENSG00000227372 E077 3.7374776 0.1173591085 0.7614966156 0.93635424 1 3743191 3743261 71 - 0.644 0.695 0.218
ENSG00000227372 E078 3.5623442 0.0532867538 0.9291312582 0.98311774 1 3743280 3743300 21 - 0.642 0.664 0.093
ENSG00000227372 E079 4.9410098 0.0643241023 0.6068140719 0.87835913 1 3743301 3743371 71 - 0.816 0.722 -0.377
ENSG00000227372 E080 13.9759551 0.0257983215 0.3350406819 0.72828764 1 3745381 3745606 226 - 1.212 1.110 -0.364
ENSG00000227372 E081 523.2548191 0.0016841027 0.0012171744 0.06053324 1 3745607 3746181 575 - 2.752 2.682 -0.232
ENSG00000227372 E082 92.4131559 0.0005550012 0.0199417270 0.23549912 1 3746182 3746186 5 - 2.003 1.923 -0.270
ENSG00000227372 E083 147.2339919 0.0010998914 0.0244625331 0.25634430 1 3746187 3746286 100 - 2.198 2.132 -0.219
ENSG00000227372 E084 178.7754511 0.0007912345 0.0079070783 0.15546678 1 3746287 3746436 150 - 2.284 2.214 -0.233
ENSG00000227372 E085 149.8618469 0.0002281836 0.0053487041 0.13076548 1 3746437 3746527 91 - 2.211 2.137 -0.247
ENSG00000227372 E086 387.7679356 0.0005939436 0.0008407805 0.04893744 1 3746528 3747373 846 - 2.617 2.555 -0.206