ENSG00000214174

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000397713 ENSG00000214174 HEK293_DMSO_6hA HEK293_OSMI2_6hA AMZ2P1 transcribed_unprocessed_pseudogene processed_transcript 9.880036 7.374398 5.750701 1.591597 0.5074929 -0.3582359 0.8176179 0.74520947 0.3133745 0.18437343 0.13821462 -1.2236711 0.07982917 0.100133333 0.05773333 -0.04240000 6.850558e-01 6.551072e-05 TRUE  
ENST00000684992 ENSG00000214174 HEK293_DMSO_6hA HEK293_OSMI2_6hA AMZ2P1 transcribed_unprocessed_pseudogene processed_transcript 9.880036 7.374398 5.750701 1.591597 0.5074929 -0.3582359 0.5613752 0.26417963 0.4060169 0.13843255 0.23466549 0.6015209 0.06125833 0.034066667 0.07553333 0.04146667 8.736210e-01 6.551072e-05 TRUE  
ENST00000685100 ENSG00000214174 HEK293_DMSO_6hA HEK293_OSMI2_6hA AMZ2P1 transcribed_unprocessed_pseudogene processed_transcript 9.880036 7.374398 5.750701 1.591597 0.5074929 -0.3582359 0.3386750 0.00000000 0.3944338 0.00000000 0.08961786 5.3378316 0.03780417 0.000000000 0.06730000 0.06730000 6.551072e-05 6.551072e-05 TRUE  
ENST00000689168 ENSG00000214174 HEK293_DMSO_6hA HEK293_OSMI2_6hA AMZ2P1 transcribed_unprocessed_pseudogene processed_transcript 9.880036 7.374398 5.750701 1.591597 0.5074929 -0.3582359 2.4419407 3.43590571 1.1573069 1.12521298 0.59838341 -1.5616994 0.25362083 0.446266667 0.18636667 -0.25990000 5.187917e-01 6.551072e-05    
ENST00000690613 ENSG00000214174 HEK293_DMSO_6hA HEK293_OSMI2_6hA AMZ2P1 transcribed_unprocessed_pseudogene processed_transcript 9.880036 7.374398 5.750701 1.591597 0.5074929 -0.3582359 0.8711542 0.21174435 0.4511642 0.21174435 0.34120862 1.0563832 0.08197917 0.035533333 0.08150000 0.04596667 7.365548e-01 6.551072e-05    
ENST00000690715 ENSG00000214174 HEK293_DMSO_6hA HEK293_OSMI2_6hA AMZ2P1 transcribed_unprocessed_pseudogene processed_transcript 9.880036 7.374398 5.750701 1.591597 0.5074929 -0.3582359 0.6280484 0.28113837 0.4428218 0.28113837 0.44282183 0.6372385 0.07474167 0.050100000 0.09030000 0.04020000 9.823566e-01 6.551072e-05 TRUE  
ENST00000691709 ENSG00000214174 HEK293_DMSO_6hA HEK293_OSMI2_6hA AMZ2P1 transcribed_unprocessed_pseudogene processed_transcript 9.880036 7.374398 5.750701 1.591597 0.5074929 -0.3582359 0.2857921 0.00000000 0.3208025 0.00000000 0.16123881 5.0478984 0.02754583 0.000000000 0.05253333 0.05253333 2.331354e-01 6.551072e-05 TRUE  
MSTRG.14928.17 ENSG00000214174 HEK293_DMSO_6hA HEK293_OSMI2_6hA AMZ2P1 transcribed_unprocessed_pseudogene   9.880036 7.374398 5.750701 1.591597 0.5074929 -0.3582359 1.2925274 0.39589646 0.7194512 0.20532577 0.45336431 0.8456998 0.12363750 0.068833333 0.11883333 0.05000000 9.139634e-01 6.551072e-05    
MSTRG.14928.20 ENSG00000214174 HEK293_DMSO_6hA HEK293_OSMI2_6hA AMZ2P1 transcribed_unprocessed_pseudogene   9.880036 7.374398 5.750701 1.591597 0.5074929 -0.3582359 0.5358066 0.04459338 0.2876557 0.04459338 0.28765573 2.4468467 0.05270000 0.007466667 0.05056667 0.04310000 9.675925e-01 6.551072e-05    
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000214174 E001 0.8089702 0.0231270283 0.517335710   17 64966550 64968025 1476 - 0.310 0.199 -0.841
ENSG00000214174 E002 0.0000000       17 64968026 64968028 3 -      
ENSG00000214174 E003 0.0000000       17 64968029 64968033 5 -      
ENSG00000214174 E004 0.0000000       17 64968034 64968035 2 -      
ENSG00000214174 E005 0.3356707 0.0283179171 0.887258623   17 64968036 64968036 1 - 0.129 0.111 -0.259
ENSG00000214174 E006 0.3356707 0.0283179171 0.887258623   17 64968037 64968037 1 - 0.129 0.111 -0.259
ENSG00000214174 E007 0.9975704 0.2721609983 0.704113548   17 64968038 64968045 8 - 0.235 0.331 0.673
ENSG00000214174 E008 2.4416908 0.2570587816 0.604449366 0.87740991 17 64968046 64968088 43 - 0.447 0.584 0.660
ENSG00000214174 E009 7.2164263 0.0370732399 0.782967920 0.94301278 17 64968089 64968110 22 - 0.880 0.942 0.234
ENSG00000214174 E010 21.2050934 0.0023597646 0.131438226 0.51246018 17 64968111 64968166 56 - 1.286 1.399 0.395
ENSG00000214174 E011 30.1208547 0.0009569048 0.428310010 0.79103167 17 64968167 64968221 55 - 1.463 1.513 0.173
ENSG00000214174 E012 70.9561464 0.0005199820 0.043909509 0.32627345 17 64968222 64968381 160 - 1.808 1.888 0.268
ENSG00000214174 E013 2.5510813 0.0784786577 0.072489838 0.40119071 17 64969315 64969425 111 - 0.310 0.675 1.839
ENSG00000214174 E014 9.4594432 0.0026842744 0.409535668 0.78004054 17 64972318 64972533 216 - 1.069 0.987 -0.301
ENSG00000214174 E015 52.6173186 0.0006401713 0.788316985 0.94466871 17 64972534 64972662 129 - 1.721 1.735 0.050
ENSG00000214174 E016 48.9850980 0.0013667555 0.234767335 0.63964494 17 64972754 64972927 174 - 1.729 1.673 -0.188
ENSG00000214174 E017 8.3572915 0.0032383473 0.002731394 0.09375630 17 64972928 64973231 304 - 0.740 1.090 1.329
ENSG00000214174 E018 3.6126341 0.0065942023 0.393689415 0.76917235 17 64973232 64973241 10 - 0.576 0.704 0.552
ENSG00000214174 E019 16.9304304 0.0017667490 0.087501778 0.43318054 17 64973242 64973352 111 - 1.317 1.182 -0.474
ENSG00000214174 E020 19.8942218 0.0015178383 0.227450066 0.63245499 17 64973353 64973517 165 - 1.365 1.278 -0.302
ENSG00000214174 E021 13.3351483 0.0019830210 0.471925029 0.81487920 17 64974555 64974641 87 - 1.191 1.129 -0.220
ENSG00000214174 E022 10.0344940 0.0220206882 0.552403397 0.85507750 17 64974642 64974950 309 - 0.989 1.059 0.254
ENSG00000214174 E023 16.2646616 0.0015723514 0.001524201 0.06893391 17 64974951 64975046 96 - 1.364 1.110 -0.897
ENSG00000214174 E024 12.6548616 0.0021401114 0.091194772 0.44054324 17 64975047 64975117 71 - 1.210 1.059 -0.545
ENSG00000214174 E025 17.6043080 0.0021611730 0.336232307 0.72903787 17 64975118 64975518 401 - 1.302 1.229 -0.258
ENSG00000214174 E026 2.9282046 0.2988578380 0.841397850 0.96076503 17 64975519 64975559 41 - 0.605 0.558 -0.213
ENSG00000214174 E027 7.5340114 0.0568250905 0.501363318 0.83036032 17 64975560 64975617 58 - 0.862 0.962 0.379