ENSG00000205726

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000399338 ENSG00000205726 HEK293_DMSO_6hA HEK293_OSMI2_6hA ITSN1 protein_coding protein_coding 16.57752 12.40731 13.80228 2.025213 2.058958 0.1535995 1.4915421 0.4991632 1.1863600 0.4991632 1.18635999 1.23245159 0.07538333 0.03033333 0.07893333 0.04860000 1.00000000 0.02913832 FALSE TRUE
ENST00000399349 ENSG00000205726 HEK293_DMSO_6hA HEK293_OSMI2_6hA ITSN1 protein_coding protein_coding 16.57752 12.40731 13.80228 2.025213 2.058958 0.1535995 1.9026057 1.4781262 1.5800723 0.2103703 0.33346452 0.09559543 0.11098333 0.12690000 0.11233333 -0.01456667 0.94984500 0.02913832 FALSE TRUE
ENST00000399352 ENSG00000205726 HEK293_DMSO_6hA HEK293_OSMI2_6hA ITSN1 protein_coding protein_coding 16.57752 12.40731 13.80228 2.025213 2.058958 0.1535995 7.3743764 2.7432527 5.9942265 0.5307089 1.56526764 1.12484137 0.43663333 0.21960000 0.42093333 0.20133333 0.02913832 0.02913832 FALSE TRUE
ENST00000440794 ENSG00000205726 HEK293_DMSO_6hA HEK293_OSMI2_6hA ITSN1 protein_coding protein_coding 16.57752 12.40731 13.80228 2.025213 2.058958 0.1535995 0.9634133 0.9575129 1.7956921 0.4851293 1.02672370 0.90019904 0.07701667 0.09206667 0.13380000 0.04173333 0.97808021 0.02913832 FALSE TRUE
ENST00000472548 ENSG00000205726 HEK293_DMSO_6hA HEK293_OSMI2_6hA ITSN1 protein_coding processed_transcript 16.57752 12.40731 13.80228 2.025213 2.058958 0.1535995 0.9133849 2.7233485 0.4660256 0.8376105 0.46602556 -2.52155845 0.06920000 0.21100000 0.03100000 -0.18000000 0.13768071 0.02913832   FALSE
ENST00000487427 ENSG00000205726 HEK293_DMSO_6hA HEK293_OSMI2_6hA ITSN1 protein_coding retained_intron 16.57752 12.40731 13.80228 2.025213 2.058958 0.1535995 1.4347721 1.3425189 1.0620304 0.2808717 0.03763598 -0.33530287 0.08407917 0.10753333 0.08200000 -0.02553333 0.74776407 0.02913832 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000205726 E001 0.1717682 0.0357349399 3.666406e-01   21 33642400 33642451 52 + 0.000 0.140 10.362
ENSG00000205726 E002 0.1717682 0.0357349399 3.666406e-01   21 33642452 33642452 1 + 0.000 0.140 12.782
ENSG00000205726 E003 0.9858018 0.2072203983 8.186822e-01   21 33642453 33642477 25 + 0.256 0.331 0.509
ENSG00000205726 E004 1.1625724 0.2750084419 9.012260e-01   21 33642478 33642482 5 + 0.319 0.331 0.074
ENSG00000205726 E005 1.6236277 0.3967257220 7.138794e-01   21 33642483 33642495 13 + 0.419 0.403 -0.087
ENSG00000205726 E006 1.6236277 0.3967257220 7.138794e-01   21 33642496 33642497 2 + 0.419 0.403 -0.087
ENSG00000205726 E007 1.6236277 0.3967257220 7.138794e-01   21 33642498 33642500 3 + 0.419 0.403 -0.087
ENSG00000205726 E008 2.9094136 0.0221034679 1.841955e-01 0.5846506089 21 33642501 33642517 17 + 0.672 0.462 -0.964
ENSG00000205726 E009 6.5427198 0.0039080008 2.606481e-01 0.6660354102 21 33642518 33642541 24 + 0.925 0.800 -0.484
ENSG00000205726 E010 27.3538438 0.0010670162 9.404806e-02 0.4461468078 21 33642542 33642713 172 + 1.498 1.402 -0.328
ENSG00000205726 E011 0.1125166 0.0323126335 6.389686e-01   21 33689322 33689383 62 + 0.102 0.000 -13.034
ENSG00000205726 E012 0.5607039 0.0191759745 4.862176e-01   21 33716431 33716555 125 + 0.254 0.139 -1.067
ENSG00000205726 E013 18.8296985 0.0026211212 9.417395e-01 0.9864033116 21 33718797 33718809 13 + 1.296 1.316 0.070
ENSG00000205726 E014 23.3011199 0.0105000761 7.210304e-01 0.9226366792 21 33718810 33718856 47 + 1.375 1.415 0.136
ENSG00000205726 E015 32.2390930 0.0009194980 1.733428e-01 0.5709265822 21 33721178 33721270 93 + 1.553 1.485 -0.232
ENSG00000205726 E016 0.3435364 0.4649141957 2.296088e-01   21 33721932 33721991 60 + 0.000 0.246 12.659
ENSG00000205726 E017 33.7544632 0.0010627716 9.044478e-04 0.0510080697 21 33722588 33722651 64 + 1.610 1.421 -0.648
ENSG00000205726 E018 0.1125166 0.0323126335 6.389686e-01   21 33735041 33735043 3 + 0.102 0.000 -13.034
ENSG00000205726 E019 50.8584443 0.0007870889 3.362555e-02 0.2928186448 21 33735044 33735204 161 + 1.753 1.664 -0.303
ENSG00000205726 E020 0.2842848 0.0275065245 8.140449e-01   21 33735306 33735626 321 + 0.102 0.140 0.519
ENSG00000205726 E021 0.0000000       21 33750107 33750142 36 +      
ENSG00000205726 E022 39.6245079 0.0025615207 5.593130e-02 0.3609766036 21 33750143 33750253 111 + 1.654 1.555 -0.338
ENSG00000205726 E023 35.9008473 0.0007652434 4.205687e-01 0.7864553868 21 33750254 33750322 69 + 1.581 1.550 -0.105
ENSG00000205726 E024 47.1556740 0.0024734185 8.345366e-01 0.9583840374 21 33751810 33751906 97 + 1.686 1.691 0.017
ENSG00000205726 E025 0.0000000       21 33754183 33754222 40 +      
ENSG00000205726 E026 49.6061801 0.0096006933 9.542617e-01 0.9893683158 21 33755297 33755397 101 + 1.699 1.718 0.065
ENSG00000205726 E027 0.1717682 0.0357349399 3.666406e-01   21 33756787 33757073 287 + 0.000 0.140 12.782
ENSG00000205726 E028 42.3196475 0.0151510807 4.275024e-01 0.7905921220 21 33761923 33761986 64 + 1.653 1.619 -0.113
ENSG00000205726 E029 60.0916815 0.0027666763 1.705851e-01 0.5677911333 21 33765875 33766012 138 + 1.805 1.756 -0.168
ENSG00000205726 E030 59.7383131 0.0017289901 1.381668e-01 0.5225524015 21 33767713 33767828 116 + 1.804 1.750 -0.180
ENSG00000205726 E031 0.2892872 0.0257593281 2.995656e-01   21 33772039 33772060 22 + 0.185 0.000 -14.090
ENSG00000205726 E032 98.6266300 0.0058192937 3.587274e-02 0.3001302408 21 33772061 33772323 263 + 2.033 1.951 -0.276
ENSG00000205726 E033 0.1767706 0.0525718469 6.354135e-01   21 33774363 33774728 366 + 0.102 0.000 -12.845
ENSG00000205726 E034 74.4295617 0.0004287162 8.218350e-02 0.4223721831 21 33774729 33774878 150 + 1.901 1.847 -0.183
ENSG00000205726 E035 75.5392957 0.0020605523 3.344771e-01 0.7279563636 21 33774968 33775108 141 + 1.894 1.865 -0.097
ENSG00000205726 E036 58.3541697 0.0397671069 7.626276e-01 0.9366997634 21 33781461 33781548 88 + 1.787 1.750 -0.124
ENSG00000205726 E037 69.0706737 0.0119606134 4.450657e-01 0.8006866709 21 33781994 33782133 140 + 1.861 1.822 -0.131
ENSG00000205726 E038 68.0168820 0.0065997997 8.725582e-01 0.9689186012 21 33794341 33794468 128 + 1.831 1.852 0.070
ENSG00000205726 E039 88.2625898 0.0045249908 4.828879e-02 0.3397474998 21 33797379 33797553 175 + 1.986 1.900 -0.290
ENSG00000205726 E040 54.6293741 0.0047106930 1.853155e-01 0.5859292428 21 33797554 33797608 55 + 1.766 1.704 -0.210
ENSG00000205726 E041 65.8141607 0.0005207844 8.262850e-01 0.9559065463 21 33799808 33799922 115 + 1.819 1.826 0.022
ENSG00000205726 E042 39.7765883 0.0006549768 8.741344e-01 0.9695460164 21 33799923 33799929 7 + 1.607 1.614 0.025
ENSG00000205726 E043 0.0000000       21 33802430 33802436 7 +      
ENSG00000205726 E044 0.0000000       21 33802437 33802444 8 +      
ENSG00000205726 E045 106.5672048 0.0018344216 4.572125e-01 0.8071788341 21 33810975 33811203 229 + 2.034 2.021 -0.044
ENSG00000205726 E046 48.8901327 0.0007851211 1.707132e-01 0.5679437009 21 33811204 33811222 19 + 1.721 1.667 -0.183
ENSG00000205726 E047 96.2546628 0.0015172247 9.720576e-03 0.1714522229 21 33813913 33814072 160 + 2.021 1.934 -0.293
ENSG00000205726 E048 5.6260089 0.0846710860 5.087443e-02 0.3464574983 21 33814073 33814507 435 + 0.619 0.988 1.469
ENSG00000205726 E049 38.0276217 0.0014973180 7.761860e-03 0.1544997038 21 33817231 33817736 506 + 1.652 1.511 -0.481
ENSG00000205726 E050 11.5108531 0.0354587879 1.918071e-02 0.2315785803 21 33818026 33818266 241 + 0.916 1.245 1.196
ENSG00000205726 E051 72.7690225 0.0007087696 2.643390e-01 0.6692438428 21 33818267 33818382 116 + 1.875 1.845 -0.102
ENSG00000205726 E052 59.7375887 0.0005627204 9.569081e-01 0.9901246625 21 33818383 33818451 69 + 1.771 1.790 0.062
ENSG00000205726 E053 42.9997867 0.0075010731 7.773041e-01 0.9414287663 21 33818452 33818472 21 + 1.629 1.657 0.095
ENSG00000205726 E054 65.1002958 0.0008908626 5.448930e-01 0.8520248081 21 33819241 33819323 83 + 1.799 1.842 0.145
ENSG00000205726 E055 67.2411975 0.0051212737 5.497352e-01 0.8539189823 21 33823487 33823653 167 + 1.836 1.822 -0.048
ENSG00000205726 E056 35.9304289 0.0228635473 8.055459e-01 0.9498431315 21 33826818 33826863 46 + 1.563 1.568 0.019
ENSG00000205726 E057 3.6965833 0.0093971808 1.171923e-03 0.0593152708 21 33828968 33829005 38 + 0.367 0.872 2.279
ENSG00000205726 E058 4.1459356 0.0057028699 1.466960e-04 0.0169399636 21 33829006 33829050 45 + 0.367 0.934 2.516
ENSG00000205726 E059 3.5877094 0.0060282048 2.273503e-05 0.0053126353 21 33829051 33829168 118 + 0.254 0.914 3.179
ENSG00000205726 E060 9.8265413 0.1232196288 1.004857e-02 0.1738877923 21 33829169 33829623 455 + 0.736 1.236 1.870
ENSG00000205726 E061 60.8426555 0.0035759765 2.525511e-01 0.6584536408 21 33829624 33829745 122 + 1.759 1.834 0.253
ENSG00000205726 E062 64.2343755 0.0065450024 7.080614e-01 0.9180832629 21 33834307 33834424 118 + 1.803 1.839 0.121
ENSG00000205726 E063 111.6983250 0.0003790244 1.550548e-01 0.5466093492 21 33836441 33836632 192 + 2.026 2.089 0.211
ENSG00000205726 E064 2.2192975 0.3080640738 9.139116e-01 0.9794205741 21 33836633 33836635 3 + 0.513 0.464 -0.240
ENSG00000205726 E065 390.0250533 0.0034362126 1.112944e-08 0.0000180541 21 33836987 33838498 1512 + 2.494 2.685 0.638
ENSG00000205726 E066 1.0984991 0.3629852046 5.694906e-01   21 33856736 33856857 122 + 0.393 0.248 -0.938
ENSG00000205726 E067 0.5187598 0.0230610149 7.694668e-02   21 33858686 33858696 11 + 0.313 0.000 -15.079
ENSG00000205726 E068 0.6999699 0.0177867209 4.017684e-02   21 33858697 33858792 96 + 0.366 0.000 -15.450
ENSG00000205726 E069 1.2375233 0.0130794497 7.204793e-02   21 33865151 33865334 184 + 0.456 0.140 -2.292
ENSG00000205726 E070 0.9205636 0.0227011930 1.284636e-02   21 33867233 33867331 99 + 0.454 0.000 -15.836
ENSG00000205726 E071 0.6312764 0.0688989723 5.210140e-02   21 33875354 33875357 4 + 0.362 0.000 -14.959
ENSG00000205726 E072 0.6312764 0.0688989723 5.210140e-02   21 33875358 33875359 2 + 0.362 0.000 -14.959
ENSG00000205726 E073 1.7217291 0.0107509229 6.511606e-02 0.3845906029 21 33875360 33875521 162 + 0.562 0.245 -1.803
ENSG00000205726 E074 1.7210761 0.0512484808 4.269952e-01 0.7903855013 21 33882243 33882455 213 + 0.365 0.515 0.789
ENSG00000205726 E075 0.5153046 0.7804722660 2.475498e-01   21 33883550 33883671 122 + 0.000 0.332 13.035
ENSG00000205726 E076 0.7419140 0.0171670219 3.039868e-01   21 33885041 33885123 83 + 0.314 0.139 -1.484
ENSG00000205726 E077 1.2215292 0.0569372004 7.000161e-01   21 33885439 33885522 84 + 0.313 0.400 0.514
ENSG00000205726 E078 2.3701592 0.1913873372 8.182160e-01 0.9539871435 21 33886287 33886460 174 + 0.497 0.560 0.300
ENSG00000205726 E079 98.5947812 0.0205574772 3.440692e-01 0.7350257127 21 33888152 33899861 11710 + 1.951 2.047 0.321