ENSG00000204852

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000480648 ENSG00000204852 HEK293_DMSO_6hA HEK293_OSMI2_6hA TCTN1 protein_coding nonsense_mediated_decay 21.37627 21.31674 16.50684 1.516013 0.8268993 -0.3687251 1.2871659 1.6312265 0.7363375 0.5745294 0.05058693 -1.1368742 0.05992083 0.07370000 0.04466667 -0.0290333333 6.827669e-01 1.375153e-12 FALSE TRUE
ENST00000550703 ENSG00000204852 HEK293_DMSO_6hA HEK293_OSMI2_6hA TCTN1 protein_coding protein_coding 21.37627 21.31674 16.50684 1.516013 0.8268993 -0.3687251 0.9770433 0.2163252 1.0089391 0.1571909 0.26298651 2.1705990 0.04066250 0.01083333 0.06280000 0.0519666667 2.556608e-01 1.375153e-12 FALSE TRUE
ENST00000551590 ENSG00000204852 HEK293_DMSO_6hA HEK293_OSMI2_6hA TCTN1 protein_coding protein_coding 21.37627 21.31674 16.50684 1.516013 0.8268993 -0.3687251 0.9992714 0.4010958 0.3318744 0.4010958 0.33187444 -0.2660081 0.05292083 0.01946667 0.01933333 -0.0001333333 9.915433e-01 1.375153e-12 FALSE TRUE
ENST00000552318 ENSG00000204852 HEK293_DMSO_6hA HEK293_OSMI2_6hA TCTN1 protein_coding nonsense_mediated_decay 21.37627 21.31674 16.50684 1.516013 0.8268993 -0.3687251 0.7939940 0.0000000 1.0098675 0.0000000 0.08665088 6.6722379 0.03267083 0.00000000 0.06106667 0.0610666667 1.375153e-12 1.375153e-12 TRUE TRUE
ENST00000614115 ENSG00000204852 HEK293_DMSO_6hA HEK293_OSMI2_6hA TCTN1 protein_coding protein_coding 21.37627 21.31674 16.50684 1.516013 0.8268993 -0.3687251 2.4366997 1.4873726 1.6781581 0.3846458 0.27024106 0.1730167 0.11414167 0.06946667 0.10310000 0.0336333333 7.238523e-01 1.375153e-12 FALSE TRUE
MSTRG.8017.38 ENSG00000204852 HEK293_DMSO_6hA HEK293_OSMI2_6hA TCTN1 protein_coding   21.37627 21.31674 16.50684 1.516013 0.8268993 -0.3687251 5.3160895 5.0594011 4.3022265 0.8823344 0.40862444 -0.2333824 0.24384167 0.23506667 0.26226667 0.0272000000 8.083605e-01 1.375153e-12 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000204852 E001 0.6517073 0.0193874923 0.015911030   12 110614027 110614062 36 + 0.399 0.000 -11.464
ENSG00000204852 E002 4.4936875 0.0050145693 0.017416126 0.22304853 12 110614063 110614101 39 + 0.890 0.566 -1.335
ENSG00000204852 E003 5.2046464 0.0046716849 0.007123336 0.14851547 12 110614102 110614105 4 + 0.949 0.596 -1.421
ENSG00000204852 E004 5.3814170 0.0043922612 0.004328942 0.11817825 12 110614106 110614106 1 + 0.967 0.596 -1.488
ENSG00000204852 E005 6.0812967 0.0069663592 0.014922651 0.20813211 12 110614107 110614111 5 + 0.985 0.677 -1.206
ENSG00000204852 E006 6.0812967 0.0069663592 0.014922651 0.20813211 12 110614112 110614112 1 + 0.985 0.677 -1.206
ENSG00000204852 E007 8.0076208 0.0488538892 0.053841704 0.35537540 12 110614113 110614123 11 + 1.081 0.807 -1.030
ENSG00000204852 E008 8.8071491 0.0273769653 0.048889396 0.34116958 12 110614124 110614125 2 + 1.105 0.857 -0.922
ENSG00000204852 E009 8.8071491 0.0273769653 0.048889396 0.34116958 12 110614126 110614127 2 + 1.105 0.857 -0.922
ENSG00000204852 E010 8.8071491 0.0273769653 0.048889396 0.34116958 12 110614128 110614128 1 + 1.105 0.857 -0.922
ENSG00000204852 E011 8.8071491 0.0273769653 0.048889396 0.34116958 12 110614129 110614129 1 + 1.105 0.857 -0.922
ENSG00000204852 E012 10.3664618 0.0142286289 0.010861152 0.18029435 12 110614130 110614136 7 + 1.186 0.902 -1.037
ENSG00000204852 E013 10.9023781 0.0213659856 0.021102899 0.24092071 12 110614137 110614138 2 + 1.197 0.931 -0.969
ENSG00000204852 E014 15.8347567 0.0132669880 0.039882280 0.31372411 12 110614139 110614147 9 + 1.316 1.117 -0.702
ENSG00000204852 E015 16.0282109 0.0192355540 0.042208735 0.32101093 12 110614148 110614152 5 + 1.325 1.118 -0.733
ENSG00000204852 E016 19.4371985 0.0139347616 0.037834840 0.30658950 12 110614153 110614163 11 + 1.396 1.206 -0.664
ENSG00000204852 E017 23.3139711 0.0096638043 0.002735892 0.09375630 12 110614164 110614164 1 + 1.500 1.254 -0.854
ENSG00000204852 E018 26.8803481 0.0049342753 0.015977472 0.21470294 12 110614165 110614167 3 + 1.523 1.352 -0.593
ENSG00000204852 E019 35.9631136 0.0008299871 0.001562574 0.06964296 12 110614168 110614180 13 + 1.649 1.468 -0.618
ENSG00000204852 E020 124.0166966 0.0014118677 0.033246545 0.29135606 12 110614181 110614402 222 + 2.125 2.052 -0.245
ENSG00000204852 E021 5.0326808 0.0043405893 0.959878325 0.99073472 12 110614403 110614463 61 + 0.769 0.765 -0.017
ENSG00000204852 E022 0.7900865 0.0172131356 0.314762668   12 110616277 110616352 76 + 0.138 0.316 1.516
ENSG00000204852 E023 0.3262289 0.0272480969 0.310922327   12 110616721 110616747 27 + 0.000 0.186 11.711
ENSG00000204852 E024 1.1308206 0.1786316525 0.588150993   12 110616748 110616904 157 + 0.242 0.369 0.842
ENSG00000204852 E025 97.1252633 0.0049524169 0.127931048 0.50714878 12 110619836 110619956 121 + 2.021 1.950 -0.238
ENSG00000204852 E026 0.0000000       12 110623531 110623583 53 +      
ENSG00000204852 E027 91.7381430 0.0064874972 0.155575393 0.54742096 12 110626362 110626434 73 + 1.998 1.925 -0.245
ENSG00000204852 E028 73.4338168 0.0079621531 0.071065285 0.39778940 12 110626435 110626492 58 + 1.918 1.815 -0.345
ENSG00000204852 E029 0.1795728 0.0327039089 0.665657861   12 110626881 110627929 1049 + 0.000 0.103 10.710
ENSG00000204852 E030 0.4979971 0.0301992518 0.152727521   12 110627930 110628051 122 + 0.000 0.256 12.266
ENSG00000204852 E031 1.3617794 0.0123702151 0.336400578   12 110628052 110628224 173 + 0.243 0.416 1.096
ENSG00000204852 E032 54.9953969 0.0087072009 0.213217583 0.61784480 12 110628767 110628796 30 + 1.779 1.701 -0.264
ENSG00000204852 E033 107.4622591 0.0097091572 0.797436598 0.94742734 12 110628797 110628918 122 + 2.031 2.015 -0.055
ENSG00000204852 E034 42.9405682 0.0865551017 0.028012636 0.27131603 12 110628919 110630287 1369 + 1.803 1.477 -1.110
ENSG00000204852 E035 115.6093299 0.0009096485 0.782033294 0.94282896 12 110632472 110632559 88 + 2.041 2.053 0.041
ENSG00000204852 E036 12.8573747 0.1870253224 0.135939570 0.51929412 12 110632560 110633449 890 + 0.996 1.194 0.716
ENSG00000204852 E037 1.9194473 0.2678821694 0.812388357 0.95223417 12 110634311 110634395 85 + 0.501 0.453 -0.237
ENSG00000204852 E038 8.5039574 0.0041859167 0.283889457 0.68665205 12 110634396 110634463 68 + 1.032 0.915 -0.435
ENSG00000204852 E039 4.0868026 0.1472290116 0.254142361 0.65986144 12 110634464 110634669 206 + 0.515 0.782 1.152
ENSG00000204852 E040 106.2341691 0.0015982422 0.151370797 0.54119926 12 110634670 110634779 110 + 1.974 2.033 0.196
ENSG00000204852 E041 8.4559752 0.3058721117 0.251987507 0.65776568 12 110635667 110635950 284 + 0.787 1.047 0.983
ENSG00000204852 E042 9.6081696 0.2420185197 0.317076517 0.71431879 12 110635951 110636244 294 + 0.949 1.045 0.353
ENSG00000204852 E043 3.8632489 0.0611346803 0.780733139 0.94248203 12 110636245 110636369 125 + 0.649 0.676 0.114
ENSG00000204852 E044 3.2547408 0.0422594913 0.336748436 0.72945550 12 110636370 110636480 111 + 0.513 0.676 0.728
ENSG00000204852 E045 65.0185517 0.0022780420 0.522087581 0.84107218 12 110636481 110636501 21 + 1.779 1.814 0.116
ENSG00000204852 E046 134.2784028 0.0002573487 0.744747570 0.93102521 12 110640383 110640517 135 + 2.103 2.116 0.043
ENSG00000204852 E047 104.3620104 0.0003424229 0.478622226 0.81856373 12 110641024 110641149 126 + 1.984 2.012 0.093
ENSG00000204852 E048 83.6298685 0.0085050310 0.921154955 0.98111379 12 110641542 110641627 86 + 1.909 1.908 0.000
ENSG00000204852 E049 3.4522417 0.3495237107 0.692785982 0.91269344 12 110641628 110641629 2 + 0.624 0.644 0.086
ENSG00000204852 E050 34.0334735 0.1501621421 0.443825955 0.79984089 12 110641630 110642248 619 + 1.498 1.553 0.188
ENSG00000204852 E051 101.5386368 0.0003653652 0.345145924 0.73573441 12 110642249 110642389 141 + 1.969 2.005 0.122
ENSG00000204852 E052 77.8550419 0.0396604339 0.060303842 0.37234106 12 110643356 110644655 1300 + 1.782 1.938 0.526
ENSG00000204852 E053 9.6060331 0.0500379079 0.426899945 0.79031575 12 110644656 110644707 52 + 0.938 1.048 0.407
ENSG00000204852 E054 18.2267558 0.0014219368 0.002366693 0.08699903 12 110644708 110644879 172 + 1.089 1.351 0.928
ENSG00000204852 E055 16.2611587 0.0070573363 0.003999666 0.11318770 12 110644880 110644966 87 + 1.019 1.302 1.014
ENSG00000204852 E056 46.7870173 0.0007043264 0.815142803 0.95301352 12 110644967 110644972 6 + 1.653 1.668 0.052
ENSG00000204852 E057 60.2664875 0.0005386690 0.710124230 0.91871068 12 110644973 110644991 19 + 1.756 1.776 0.068
ENSG00000204852 E058 133.0945913 0.0002459068 0.362946056 0.74905641 12 110644992 110645129 138 + 2.089 2.120 0.103
ENSG00000204852 E059 11.8622113 0.0308095671 0.597408055 0.87449903 12 110645130 110645143 14 + 1.057 1.107 0.180
ENSG00000204852 E060 58.6402001 0.0542876716 0.099626220 0.45664153 12 110645144 110646427 1284 + 1.672 1.810 0.468
ENSG00000204852 E061 20.7588498 0.0240393984 0.050207421 0.34465848 12 110646428 110646734 307 + 1.191 1.389 0.692
ENSG00000204852 E062 33.5969951 0.0318049479 0.152157475 0.54221272 12 110646735 110647195 461 + 1.448 1.563 0.397
ENSG00000204852 E063 13.5177035 0.0019538307 0.231542513 0.63658488 12 110647196 110647210 15 + 1.075 1.189 0.410
ENSG00000204852 E064 122.3973490 0.0003268307 0.418996473 0.78560418 12 110647211 110647292 82 + 2.053 2.082 0.096
ENSG00000204852 E065 69.7982502 0.0015848896 0.066146764 0.38702393 12 110647293 110647300 8 + 1.774 1.861 0.292
ENSG00000204852 E066 75.5542263 0.0004319290 0.066057142 0.38683100 12 110647301 110647336 36 + 1.812 1.891 0.267
ENSG00000204852 E067 19.5793442 0.1078111603 0.213900274 0.61845610 12 110647337 110647748 412 + 1.201 1.351 0.527
ENSG00000204852 E068 112.4629118 0.0003006685 0.004175582 0.11582383 12 110647749 110647893 145 + 1.970 2.071 0.337
ENSG00000204852 E069 59.1526289 0.0005576865 0.040539331 0.31595232 12 110649043 110649100 58 + 1.697 1.797 0.336
ENSG00000204852 E070 7.3937931 0.0306724568 0.238761182 0.64408538 12 110649101 110649430 330 + 0.796 0.970 0.665
ENSG00000204852 E071 6.3571894 0.0043215608 0.934817317 0.98466592 12 110663058 110663431 374 + 0.846 0.838 -0.029