ENSG00000204348

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000337523 ENSG00000204348 HEK293_DMSO_6hA HEK293_OSMI2_6hA DXO protein_coding protein_coding 36.72428 37.84701 52.39771 1.645723 6.11845 0.4692183 22.239767 16.583905 34.235270 2.5127504 7.3516968 1.04525126 0.58572917 0.4339000 0.63776667 0.20386667 0.21922183 0.02207457 FALSE  
ENST00000473976 ENSG00000204348 HEK293_DMSO_6hA HEK293_OSMI2_6hA DXO protein_coding retained_intron 36.72428 37.84701 52.39771 1.645723 6.11845 0.4692183 2.604844 3.857870 3.676449 0.8946901 0.8711166 -0.06930723 0.07447917 0.1042333 0.07493333 -0.02930000 0.74796145 0.02207457 TRUE  
ENST00000477826 ENSG00000204348 HEK293_DMSO_6hA HEK293_OSMI2_6hA DXO protein_coding retained_intron 36.72428 37.84701 52.39771 1.645723 6.11845 0.4692183 2.616368 4.570502 3.112487 0.4821445 0.3918176 -0.55281023 0.07658750 0.1201000 0.06043333 -0.05966667 0.02207457 0.02207457 TRUE  
ENST00000491327 ENSG00000204348 HEK293_DMSO_6hA HEK293_OSMI2_6hA DXO protein_coding retained_intron 36.72428 37.84701 52.39771 1.645723 6.11845 0.4692183 1.878500 3.360849 1.953992 0.7838518 0.4930254 -0.77932331 0.06056250 0.0892000 0.04070000 -0.04850000 0.34293915 0.02207457 TRUE  
ENST00000498357 ENSG00000204348 HEK293_DMSO_6hA HEK293_OSMI2_6hA DXO protein_coding retained_intron 36.72428 37.84701 52.39771 1.645723 6.11845 0.4692183 2.476634 4.739282 3.251380 0.3741725 0.6990118 -0.54222694 0.07215417 0.1248000 0.06636667 -0.05843333 0.25890937 0.02207457 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000204348 E001 0.837033 0.0162974261 0.115349046   6 31969810 31969812 3 - 0.108 0.384 2.322
ENSG00000204348 E002 1.241639 0.0131738111 0.330415013   6 31969813 31969814 2 - 0.267 0.443 1.064
ENSG00000204348 E003 3.345808 0.0062938326 0.517570439 0.83892012 6 31969815 31969816 2 - 0.583 0.691 0.464
ENSG00000204348 E004 37.553054 0.0007876935 0.787392241 0.94438399 6 31969817 31969843 27 - 1.574 1.602 0.097
ENSG00000204348 E005 95.726770 0.0017622938 0.976484486 0.99454151 6 31969844 31969886 43 - 1.977 1.993 0.051
ENSG00000204348 E006 144.222635 0.0075863936 0.965983303 0.99217974 6 31969887 31969906 20 - 2.155 2.168 0.042
ENSG00000204348 E007 198.627304 0.0026132025 0.794647133 0.94639304 6 31969907 31969947 41 - 2.295 2.302 0.023
ENSG00000204348 E008 189.278339 0.0031404889 0.822110731 0.95500291 6 31969948 31969959 12 - 2.275 2.282 0.024
ENSG00000204348 E009 262.698018 0.0023558360 0.864932005 0.96707512 6 31969960 31970024 65 - 2.414 2.425 0.038
ENSG00000204348 E010 30.505447 0.0405250240 0.016648327 0.21842852 6 31970025 31970108 84 - 1.341 1.618 0.952
ENSG00000204348 E011 406.389349 0.0001735081 0.597517787 0.87456675 6 31970109 31970203 95 - 2.597 2.621 0.079
ENSG00000204348 E012 105.720025 0.0537265422 0.050052502 0.34425728 6 31970204 31970342 139 - 1.914 2.126 0.710
ENSG00000204348 E013 288.852288 0.0013164710 0.970769453 0.99319380 6 31970343 31970378 36 - 2.456 2.471 0.053
ENSG00000204348 E014 325.453328 0.0026370996 0.961123902 0.99105737 6 31970379 31970441 63 - 2.506 2.524 0.060
ENSG00000204348 E015 240.327649 0.0029544524 0.744546427 0.93095885 6 31970442 31970478 37 - 2.382 2.386 0.013
ENSG00000204348 E016 92.448775 0.0663502074 0.055658196 0.36014237 6 31970479 31970592 114 - 1.848 2.073 0.758
ENSG00000204348 E017 44.245851 0.0837050577 0.204070227 0.60804231 6 31970593 31970605 13 - 1.574 1.728 0.524
ENSG00000204348 E018 258.252946 0.0014148771 0.371322140 0.75405348 6 31970606 31970642 37 - 2.418 2.409 -0.031
ENSG00000204348 E019 339.990617 0.0001946397 0.248055943 0.65353470 6 31970643 31970752 110 - 2.537 2.528 -0.028
ENSG00000204348 E020 230.393705 0.0001957924 0.719157497 0.92185390 6 31970753 31970825 73 - 2.349 2.372 0.076
ENSG00000204348 E021 56.144467 0.0923589678 0.129732181 0.50983707 6 31970826 31970897 72 - 1.655 1.844 0.640
ENSG00000204348 E022 34.201745 0.0490430807 0.157010021 0.54971421 6 31970898 31970911 14 - 1.459 1.622 0.555
ENSG00000204348 E023 505.921465 0.0012215851 0.006234588 0.13993328 6 31970912 31971139 228 - 2.721 2.680 -0.137
ENSG00000204348 E024 213.928204 0.0002004852 0.026202623 0.26320000 6 31971140 31971147 8 - 2.349 2.309 -0.133
ENSG00000204348 E025 74.654366 0.0554864250 0.067041826 0.38916292 6 31971148 31971319 172 - 1.769 1.972 0.683
ENSG00000204348 E026 663.103421 0.0001215254 0.002035264 0.08040921 6 31971320 31971581 262 - 2.833 2.805 -0.092
ENSG00000204348 E027 350.411034 0.0001567670 0.005298140 0.13041436 6 31971582 31971681 100 - 2.563 2.524 -0.129
ENSG00000204348 E028 64.850663 0.0062380892 0.002748100 0.09393511 6 31971682 31971725 44 - 1.719 1.905 0.629
ENSG00000204348 E029 95.418452 0.0277105871 0.031721809 0.28621145 6 31971726 31971928 203 - 1.881 2.074 0.650
ENSG00000204348 E030 344.525575 0.0006203709 0.098114710 0.45379286 6 31971929 31972290 362 - 2.549 2.527 -0.074