ENSG00000203485

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000330634 ENSG00000203485 HEK293_DMSO_6hA HEK293_OSMI2_6hA INF2 protein_coding protein_coding 29.93599 28.71711 43.2033 2.486861 4.695405 0.5890625 2.968199 2.548643 4.151504 0.1116794 0.8364573 0.7017263 0.09783750 0.08966667 0.09406667 0.0044000000 0.9592742 0.005640955 FALSE TRUE
ENST00000398337 ENSG00000203485 HEK293_DMSO_6hA HEK293_OSMI2_6hA INF2 protein_coding protein_coding 29.93599 28.71711 43.2033 2.486861 4.695405 0.5890625 8.193311 6.560746 14.774892 0.6641863 2.4881554 1.1699947 0.25507083 0.22786667 0.33730000 0.1094333333 0.0422256 0.005640955 FALSE TRUE
ENST00000674631 ENSG00000203485 HEK293_DMSO_6hA HEK293_OSMI2_6hA INF2 protein_coding protein_coding 29.93599 28.71711 43.2033 2.486861 4.695405 0.5890625 4.010338 4.357572 6.497626 0.6893768 0.7517945 0.5752998 0.12255417 0.14980000 0.15016667 0.0003666667 1.0000000 0.005640955 FALSE TRUE
ENST00000675557 ENSG00000203485 HEK293_DMSO_6hA HEK293_OSMI2_6hA INF2 protein_coding retained_intron 29.93599 28.71711 43.2033 2.486861 4.695405 0.5890625 2.041909 3.019749 1.600415 0.3150466 0.3928920 -0.9117656 0.07923750 0.10543333 0.03996667 -0.0654666667 0.1389197 0.005640955 FALSE FALSE
ENST00000675771 ENSG00000203485 HEK293_DMSO_6hA HEK293_OSMI2_6hA INF2 protein_coding nonsense_mediated_decay 29.93599 28.71711 43.2033 2.486861 4.695405 0.5890625 2.825957 1.474730 3.392928 0.8111655 1.7652208 1.1965761 0.10299583 0.05636667 0.07093333 0.0145666667 0.9841010 0.005640955 FALSE TRUE
ENST00000675797 ENSG00000203485 HEK293_DMSO_6hA HEK293_OSMI2_6hA INF2 protein_coding nonsense_mediated_decay 29.93599 28.71711 43.2033 2.486861 4.695405 0.5890625 2.825336 2.778451 2.692733 1.3948177 1.4120253 -0.0450445 0.09348333 0.08920000 0.06776667 -0.0214333333 0.9805994 0.005640955 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000203485 E001 0.1795728 0.0328056935 3.384440e-01   14 104681146 104681582 437 + 0.000 0.142 9.199
ENSG00000203485 E002 0.0000000       14 104684063 104684932 870 +      
ENSG00000203485 E003 0.0000000       14 104688307 104688572 266 +      
ENSG00000203485 E004 0.5297488 0.0243420269 8.119880e-01   14 104689152 104689245 94 + 0.182 0.142 -0.427
ENSG00000203485 E005 0.1767706 0.0387845914 6.866382e-01   14 104689523 104689600 78 + 0.100 0.000 -11.446
ENSG00000203485 E006 0.6970775 0.5294835168 8.274499e-01   14 104689601 104689605 5 + 0.190 0.250 0.511
ENSG00000203485 E007 1.1625724 0.1258690249 9.817384e-01   14 104689606 104689608 3 + 0.312 0.335 0.148
ENSG00000203485 E008 6.2041997 0.1594660982 4.447754e-02 0.328197399 14 104689609 104689617 9 + 0.977 0.570 -1.641
ENSG00000203485 E009 10.7762425 0.0586244343 2.378275e-02 0.253669894 14 104689618 104689620 3 + 1.171 0.859 -1.150
ENSG00000203485 E010 10.9574526 0.0615905990 2.168061e-02 0.243818955 14 104689621 104689622 2 + 1.180 0.860 -1.180
ENSG00000203485 E011 100.4287414 0.0039596202 3.804094e-03 0.110436679 14 104689623 104689739 117 + 2.051 1.923 -0.430
ENSG00000203485 E012 4.3413660 0.0713608683 9.011089e-02 0.438743172 14 104695990 104696490 501 + 0.816 0.523 -1.246
ENSG00000203485 E013 0.1767706 0.0387845914 6.866382e-01   14 104699368 104699598 231 + 0.100 0.000 -11.446
ENSG00000203485 E014 0.2842848 0.0266452429 7.730667e-01   14 104699599 104699803 205 + 0.100 0.142 0.582
ENSG00000203485 E015 0.1125166 0.0323163258 6.894136e-01   14 104699804 104699826 23 + 0.100 0.000 -11.459
ENSG00000203485 E016 0.0000000       14 104699827 104699834 8 +      
ENSG00000203485 E017 0.3529782 0.0295053070 7.786294e-01   14 104700678 104700709 32 + 0.100 0.142 0.575
ENSG00000203485 E018 0.5325511 0.0206086087 3.678282e-01   14 104700737 104700864 128 + 0.100 0.249 1.577
ENSG00000203485 E019 74.1437377 0.0004345822 2.295558e-02 0.249821103 14 104701357 104701365 9 + 1.906 1.815 -0.308
ENSG00000203485 E020 310.5403746 0.0001406304 6.646191e-06 0.002294445 14 104701366 104701756 391 + 2.525 2.437 -0.295
ENSG00000203485 E021 17.5450320 0.0016740028 2.009888e-03 0.079888848 14 104702512 104703104 593 + 1.129 1.385 0.900
ENSG00000203485 E022 204.3438675 0.0001641230 2.663196e-01 0.670988132 14 104703105 104703220 116 + 2.319 2.294 -0.081
ENSG00000203485 E023 115.1124546 0.0005643956 1.060564e-01 0.468329575 14 104703295 104703305 11 + 2.086 2.033 -0.176
ENSG00000203485 E024 238.7288692 0.0001679221 4.648918e-02 0.334375431 14 104703306 104703454 149 + 2.396 2.353 -0.143
ENSG00000203485 E025 119.1995099 0.0002425595 9.166644e-03 0.166920764 14 104703916 104703949 34 + 2.111 2.028 -0.276
ENSG00000203485 E026 284.4871550 0.0012063403 1.149941e-03 0.058668569 14 104703950 104704809 860 + 2.485 2.404 -0.269
ENSG00000203485 E027 117.9495599 0.0005955177 6.965936e-01 0.913819343 14 104706035 104706152 118 + 2.078 2.068 -0.034
ENSG00000203485 E028 53.0076214 0.0007864782 8.086359e-01 0.951019554 14 104706153 104706176 24 + 1.731 1.724 -0.026
ENSG00000203485 E029 3.9252200 0.1155833966 1.329453e-01 0.514568594 14 104706600 104706697 98 + 0.553 0.831 1.168
ENSG00000203485 E030 108.4033710 0.0003189028 2.508339e-01 0.656637477 14 104706910 104707051 142 + 2.048 2.012 -0.120
ENSG00000203485 E031 148.7162044 0.0004011665 3.120713e-01 0.709826860 14 104707253 104707847 595 + 2.180 2.154 -0.090
ENSG00000203485 E032 39.7501585 0.0008045836 6.873347e-01 0.910874251 14 104707848 104707863 16 + 1.610 1.591 -0.064
ENSG00000203485 E033 106.4301716 0.0032689879 6.109943e-01 0.880433920 14 104707864 104708002 139 + 2.035 2.017 -0.061
ENSG00000203485 E034 0.8045917 0.1958649333 5.085244e-01   14 104708291 104708435 145 + 0.181 0.336 1.175
ENSG00000203485 E035 128.9048944 0.0005349746 3.401418e-01 0.732035706 14 104708436 104708531 96 + 2.119 2.091 -0.092
ENSG00000203485 E036 112.2586741 0.0002863761 5.013899e-01 0.830366630 14 104708532 104708587 56 + 2.055 2.036 -0.064
ENSG00000203485 E037 11.6059434 0.2315654567 3.155216e-01 0.712584714 14 104708588 104708670 83 + 1.032 1.162 0.468
ENSG00000203485 E038 117.2686713 0.0011525359 3.728838e-01 0.755256244 14 104708671 104708732 62 + 2.052 2.088 0.120
ENSG00000203485 E039 86.5665639 0.0040662070 1.749603e-01 0.572838411 14 104709281 104709293 13 + 1.904 1.976 0.242
ENSG00000203485 E040 152.1621583 0.0002226561 9.460546e-01 0.987423853 14 104709294 104709383 90 + 2.179 2.181 0.006
ENSG00000203485 E041 132.3950313 0.0004204024 8.366806e-01 0.959162154 14 104709620 104709705 86 + 2.118 2.128 0.033
ENSG00000203485 E042 107.9236136 0.0006818229 8.849282e-01 0.972517727 14 104710088 104710188 101 + 2.033 2.041 0.028
ENSG00000203485 E043 5.2073996 0.0338142090 1.270396e-02 0.194379516 14 104710725 104710881 157 + 0.587 0.960 1.505
ENSG00000203485 E044 4.7697895 0.0121938184 3.333857e-03 0.104019979 14 104710882 104710918 37 + 0.524 0.942 1.728
ENSG00000203485 E045 4.8290411 0.0322063544 2.626190e-03 0.091946609 14 104710919 104710936 18 + 0.490 0.961 1.961
ENSG00000203485 E046 93.3422081 0.0015578860 5.883771e-01 0.870584549 14 104710937 104710989 53 + 1.961 1.988 0.091
ENSG00000203485 E047 79.6735051 0.0009083232 2.137666e-01 0.618366946 14 104710990 104711007 18 + 1.878 1.934 0.187
ENSG00000203485 E048 9.2449508 0.0811104833 7.043521e-03 0.147930911 14 104711008 104711011 4 + 0.747 1.197 1.686
ENSG00000203485 E049 14.3856187 0.1092333955 6.717742e-03 0.144530773 14 104711012 104711078 67 + 0.922 1.380 1.644
ENSG00000203485 E050 72.0964936 0.0004784648 5.294644e-01 0.844701589 14 104711079 104711083 5 + 1.845 1.875 0.102
ENSG00000203485 E051 146.9087457 0.0002114633 4.194841e-01 0.785750051 14 104711084 104711186 103 + 2.154 2.181 0.090
ENSG00000203485 E052 141.1580218 0.0002140331 9.998087e-02 0.457392997 14 104711629 104711699 71 + 2.125 2.178 0.174
ENSG00000203485 E053 212.9508907 0.0004625507 3.288998e-01 0.723580762 14 104712433 104712553 121 + 2.310 2.340 0.100
ENSG00000203485 E054 1.8988606 0.0097192997 5.133551e-04 0.036667055 14 104712713 104712827 115 + 0.100 0.688 3.900
ENSG00000203485 E055 110.1188482 0.0014749787 9.116045e-01 0.978891350 14 104712828 104712832 5 + 2.034 2.045 0.037
ENSG00000203485 E056 271.3844574 0.0022732172 9.464274e-01 0.987441460 14 104712833 104712992 160 + 2.423 2.437 0.049
ENSG00000203485 E057 4.9855536 0.0051278331 1.361306e-02 0.200655573 14 104713202 104713206 5 + 0.586 0.922 1.365
ENSG00000203485 E058 203.9301726 0.0004634870 9.748924e-01 0.994132506 14 104713207 104713304 98 + 2.303 2.308 0.014
ENSG00000203485 E059 83.5267720 0.0003722735 4.021383e-01 0.774913806 14 104713305 104713309 5 + 1.932 1.903 -0.097
ENSG00000203485 E060 82.1254727 0.0003585325 7.932224e-01 0.945931364 14 104713445 104713448 4 + 1.916 1.910 -0.022
ENSG00000203485 E061 204.9191643 0.0001786271 4.786265e-01 0.818563729 14 104713449 104713606 158 + 2.315 2.300 -0.047
ENSG00000203485 E062 4.7575532 0.0061710172 4.530625e-06 0.001741915 14 104713821 104713933 113 + 0.361 1.013 2.843
ENSG00000203485 E063 162.7643453 0.0002350382 3.339113e-02 0.291974567 14 104714203 104714283 81 + 2.236 2.179 -0.190
ENSG00000203485 E064 176.5377270 0.0018964664 4.776981e-01 0.818095098 14 104714284 104714395 112 + 2.258 2.235 -0.076
ENSG00000203485 E065 185.6017713 0.0001854173 4.086302e-01 0.779474257 14 104714396 104714507 112 + 2.256 2.281 0.083
ENSG00000203485 E066 206.7030157 0.0001548285 2.919900e-03 0.096995492 14 104714508 104714588 81 + 2.279 2.355 0.254
ENSG00000203485 E067 353.0510339 0.0005058663 2.161074e-02 0.243418238 14 104714589 104714856 268 + 2.524 2.575 0.170
ENSG00000203485 E068 54.3576606 0.0065465556 1.705489e-01 0.567761830 14 104714857 104715280 424 + 1.694 1.787 0.314
ENSG00000203485 E069 6.1285092 0.1513867296 1.635508e-01 0.558458954 14 104715281 104715283 3 + 0.674 1.017 1.335
ENSG00000203485 E070 35.5228290 0.0211679250 7.265780e-01 0.924516795 14 104715284 104715340 57 + 1.574 1.546 -0.095
ENSG00000203485 E071 14.4881568 0.1219937907 7.630533e-03 0.153663272 14 104715725 104715832 108 + 0.923 1.385 1.658
ENSG00000203485 E072 22.7167469 0.1112468542 2.764881e-03 0.094350437 14 104715833 104716017 185 + 1.089 1.581 1.718
ENSG00000203485 E073 6.0032852 0.0909941070 7.758452e-02 0.412713980 14 104717548 104717562 15 + 0.676 0.979 1.188
ENSG00000203485 E074 11.3913782 0.0728144935 1.177700e-01 0.489506606 14 104717563 104717646 84 + 0.962 1.198 0.857
ENSG00000203485 E075 504.8968691 0.0015025503 3.030616e-02 0.280777819 14 104718795 104722535 3741 + 2.676 2.731 0.184