ENSG00000198718

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000361462 ENSG00000198718 HEK293_DMSO_6hA HEK293_OSMI2_6hA TOGARAM1 protein_coding protein_coding 1.469956 0.8307365 0.5358301 0.3938133 0.03154096 -0.6232018 0.66464111 0.01981589 0.40054752 0.01981589 0.07783195 3.783396 0.41035000 0.03263333 0.75113333 0.71850000 0.04327386 0.04327386 FALSE TRUE
ENST00000361577 ENSG00000198718 HEK293_DMSO_6hA HEK293_OSMI2_6hA TOGARAM1 protein_coding protein_coding 1.469956 0.8307365 0.5358301 0.3938133 0.03154096 -0.6232018 0.05170814 0.05363566 0.00000000 0.05363566 0.00000000 -2.669835 0.03552917 0.08833333 0.00000000 -0.08833333 0.77793404 0.04327386 FALSE TRUE
ENST00000555586 ENSG00000198718 HEK293_DMSO_6hA HEK293_OSMI2_6hA TOGARAM1 protein_coding retained_intron 1.469956 0.8307365 0.5358301 0.3938133 0.03154096 -0.6232018 0.01651062 0.00000000 0.02677818 0.00000000 0.02677818 1.878850 0.01860000 0.00000000 0.05030000 0.05030000 0.69979828 0.04327386   FALSE
ENST00000556105 ENSG00000198718 HEK293_DMSO_6hA HEK293_OSMI2_6hA TOGARAM1 protein_coding retained_intron 1.469956 0.8307365 0.5358301 0.3938133 0.03154096 -0.6232018 0.10291880 0.16973007 0.00000000 0.13034030 0.00000000 -4.167760 0.05472917 0.18513333 0.00000000 -0.18513333 0.35426132 0.04327386 FALSE FALSE
ENST00000556823 ENSG00000198718 HEK293_DMSO_6hA HEK293_OSMI2_6hA TOGARAM1 protein_coding protein_coding 1.469956 0.8307365 0.5358301 0.3938133 0.03154096 -0.6232018 0.15521835 0.25965194 0.00000000 0.13116413 0.00000000 -4.753027 0.19597500 0.28410000 0.00000000 -0.28410000 0.26340673 0.04327386 FALSE FALSE
ENST00000557423 ENSG00000198718 HEK293_DMSO_6hA HEK293_OSMI2_6hA TOGARAM1 protein_coding nonsense_mediated_decay 1.469956 0.8307365 0.5358301 0.3938133 0.03154096 -0.6232018 0.01213083 0.00000000 0.06173620 0.00000000 0.06173620 2.842701 0.01772917 0.00000000 0.11596667 0.11596667 0.74103302 0.04327386 TRUE TRUE
MSTRG.9457.4 ENSG00000198718 HEK293_DMSO_6hA HEK293_OSMI2_6hA TOGARAM1 protein_coding   1.469956 0.8307365 0.5358301 0.3938133 0.03154096 -0.6232018 0.35008146 0.30134667 0.02718958 0.21048336 0.02718958 -3.065552 0.21192083 0.37570000 0.04593333 -0.32976667 0.58130655 0.04327386 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000198718 E001 0.0000000       14 44962190 44962207 18 +      
ENSG00000198718 E002 0.1767706 0.040090974 4.924671e-01   14 44962208 44962212 5 + 0.123 0.000 -8.566
ENSG00000198718 E003 0.1767706 0.040090974 4.924671e-01   14 44962213 44962213 1 + 0.123 0.000 -11.178
ENSG00000198718 E004 0.3312313 0.025523709 1.000000e+00   14 44962214 44962218 5 + 0.123 0.116 -0.091
ENSG00000198718 E005 17.7149361 0.002003777 3.636072e-05 0.007181524 14 44962219 44964467 2249 + 1.418 1.103 -1.108
ENSG00000198718 E006 0.0000000       14 44995480 44995503 24 +      
ENSG00000198718 E007 1.6208910 0.011809214 6.053153e-01   14 44995746 44995818 73 + 0.363 0.454 0.494
ENSG00000198718 E008 2.3409679 0.010916747 1.391004e-01 0.523877545 14 44995819 44995902 84 + 0.364 0.610 1.228
ENSG00000198718 E009 0.3312313 0.025523709 1.000000e+00   14 44995903 44997404 1502 + 0.123 0.116 -0.091
ENSG00000198718 E010 3.0075488 0.007154356 1.381125e-01 0.522524291 14 44999363 44999497 135 + 0.471 0.698 1.027
ENSG00000198718 E011 5.4489693 0.005690410 5.910287e-01 0.871910810 14 45004061 45004366 306 + 0.857 0.794 -0.249
ENSG00000198718 E012 4.4396225 0.005975683 1.987585e-01 0.601846774 14 45006008 45006267 260 + 0.817 0.641 -0.719
ENSG00000198718 E013 1.7318314 0.045677002 1.586616e-01 0.552218069 14 45006268 45008147 1880 + 0.296 0.539 1.333
ENSG00000198718 E014 2.9648542 0.007729402 4.249804e-01 0.789301668 14 45008913 45009145 233 + 0.662 0.539 -0.547
ENSG00000198718 E015 1.2011810 0.400260371 3.935796e-01   14 45011887 45011974 88 + 0.226 0.405 1.177
ENSG00000198718 E016 3.2417900 0.078987694 5.238133e-01 0.842037334 14 45011975 45012075 101 + 0.585 0.695 0.473
ENSG00000198718 E017 1.2388367 0.013568818 9.404604e-01   14 45022910 45022973 64 + 0.363 0.348 -0.087
ENSG00000198718 E018 0.3312313 0.025523709 1.000000e+00   14 45025473 45025782 310 + 0.123 0.116 -0.091
ENSG00000198718 E019 2.4471767 0.160016610 6.900675e-01 0.911862900 14 45025783 45025872 90 + 0.539 0.574 0.162
ENSG00000198718 E020 4.1320800 0.006031766 5.460589e-01 0.852407444 14 45027299 45027474 176 + 0.662 0.749 0.357
ENSG00000198718 E021 4.4986403 0.005155397 4.726913e-01 0.815388165 14 45028176 45028329 154 + 0.794 0.698 -0.389
ENSG00000198718 E022 4.7708617 0.005567866 2.287862e-01 0.633999875 14 45032223 45032376 154 + 0.857 0.698 -0.633
ENSG00000198718 E023 4.7903694 0.005439386 5.519081e-02 0.358932271 14 45043686 45043791 106 + 0.895 0.641 -1.019
ENSG00000198718 E024 7.9342308 0.003893495 5.349500e-01 0.847424689 14 45044635 45044870 236 + 0.992 0.923 -0.259
ENSG00000198718 E025 6.0756552 0.005460310 6.023396e-01 0.876645426 14 45046545 45046703 159 + 0.895 0.835 -0.232
ENSG00000198718 E026 6.6655525 0.008211679 4.524913e-01 0.804846205 14 45052436 45052562 127 + 0.838 0.923 0.326
ENSG00000198718 E027 6.4874658 0.005309584 2.837275e-01 0.686516694 14 45054431 45054549 119 + 0.795 0.923 0.494
ENSG00000198718 E028 10.2279589 0.004464691 4.576535e-01 0.807398320 14 45066578 45066767 190 + 1.007 1.081 0.270
ENSG00000198718 E029 2.7389310 0.054299120 4.430607e-01 0.799443932 14 45068424 45068441 18 + 0.475 0.638 0.753
ENSG00000198718 E030 10.2051814 0.002745160 2.186379e-01 0.623251986 14 45068442 45068643 202 + 0.992 1.113 0.442
ENSG00000198718 E031 7.4851315 0.003473772 2.210772e-01 0.625682174 14 45071712 45071798 87 + 0.858 0.996 0.521
ENSG00000198718 E032 22.9214817 0.001672258 8.662786e-02 0.431134485 14 45073296 45074431 1136 + 1.321 1.433 0.389