ENSG00000198586

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000359766 ENSG00000198586 HEK293_DMSO_6hA HEK293_OSMI2_6hA TLK1 protein_coding nonsense_mediated_decay 8.466433 2.475916 4.622346 0.702641 1.20207 0.8979653 2.1923071 0.7503415 1.491365 0.2189617 0.3763372 0.9815555 0.26682083 0.3110667 0.3239000 0.01283333 9.578621e-01 1.790655e-10 FALSE TRUE
ENST00000431350 ENSG00000198586 HEK293_DMSO_6hA HEK293_OSMI2_6hA TLK1 protein_coding protein_coding 8.466433 2.475916 4.622346 0.702641 1.20207 0.8979653 2.5583271 1.2350903 1.583835 0.4143086 0.2918656 0.3562524 0.38838333 0.5220667 0.3624333 -0.15963333 7.360650e-01 1.790655e-10 FALSE TRUE
ENST00000434911 ENSG00000198586 HEK293_DMSO_6hA HEK293_OSMI2_6hA TLK1 protein_coding protein_coding 8.466433 2.475916 4.622346 0.702641 1.20207 0.8979653 0.1047499 0.4818434 0.000000 0.2652663 0.0000000 -5.6201270 0.02369583 0.1637333 0.0000000 -0.16373333 1.504091e-01 1.790655e-10 FALSE TRUE
ENST00000521943 ENSG00000198586 HEK293_DMSO_6hA HEK293_OSMI2_6hA TLK1 protein_coding protein_coding 8.466433 2.475916 4.622346 0.702641 1.20207 0.8979653 3.4460802 0.0000000 1.483623 0.0000000 0.4931770 7.2226724 0.30416667 0.0000000 0.3037000 0.30370000 1.790655e-10 1.790655e-10 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000198586 E001 21.3713022 0.0028190621 0.0255533745 0.26051435 2 170990823 170992153 1331 - 1.274 1.443 0.585
ENSG00000198586 E002 175.0414592 0.0002676170 0.0004254094 0.03274229 2 170992154 170993506 1353 - 2.210 2.293 0.279
ENSG00000198586 E003 50.7834463 0.0007987441 0.9189055458 0.98054334 2 170993507 170993726 220 - 1.710 1.713 0.012
ENSG00000198586 E004 52.1563054 0.0043150086 0.5213466043 0.84070634 2 170993727 170993956 230 - 1.705 1.743 0.129
ENSG00000198586 E005 27.8329371 0.0010835217 0.1981646307 0.60131327 2 170996653 170996723 71 - 1.427 1.508 0.279
ENSG00000198586 E006 22.1696363 0.0014770971 0.7580344513 0.93521298 2 170996724 170996760 37 - 1.384 1.360 -0.085
ENSG00000198586 E007 31.9860535 0.0018956934 0.8521091660 0.96344934 2 170997712 170997823 112 - 1.532 1.519 -0.046
ENSG00000198586 E008 35.0010938 0.0009562046 0.3269531303 0.72236842 2 171006147 171006282 136 - 1.584 1.524 -0.204
ENSG00000198586 E009 37.0901306 0.0026844633 0.3799129536 0.76009725 2 171006474 171006643 170 - 1.595 1.544 -0.174
ENSG00000198586 E010 25.1424269 0.0012762881 0.1849971096 0.58555739 2 171006800 171006889 90 - 1.454 1.360 -0.326
ENSG00000198586 E011 22.6497516 0.0016712184 0.5577888525 0.85719579 2 171006972 171007063 92 - 1.397 1.352 -0.157
ENSG00000198586 E012 24.5508531 0.0109173484 0.1124668487 0.47996504 2 171011373 171011454 82 - 1.468 1.319 -0.518
ENSG00000198586 E013 30.2424113 0.0010017388 0.4035884144 0.77589602 2 171014851 171014948 98 - 1.517 1.462 -0.190
ENSG00000198586 E014 1.4733117 0.0120124407 0.6096005913   2 171022872 171023129 258 - 0.436 0.346 -0.509
ENSG00000198586 E015 17.5816112 0.0015373535 0.8253160283 0.95571325 2 171028339 171028344 6 - 1.275 1.256 -0.066
ENSG00000198586 E016 27.7977176 0.0009683512 0.4368249033 0.79570212 2 171028345 171028405 61 - 1.483 1.430 -0.182
ENSG00000198586 E017 0.3563434 0.0586157158 0.7276443170   2 171045231 171046173 943 - 0.096 0.148 0.707
ENSG00000198586 E018 39.7368589 0.0008273694 0.9801715567 0.99518779 2 171046174 171046362 189 - 1.611 1.610 -0.004
ENSG00000198586 E019 28.9848226 0.0009814327 0.6666849179 0.90299969 2 171049814 171049950 137 - 1.472 1.497 0.084
ENSG00000198586 E020 22.8647217 0.0027418627 0.4874418057 0.82315326 2 171050064 171050174 111 - 1.405 1.352 -0.186
ENSG00000198586 E021 0.0000000       2 171053717 171053760 44 -      
ENSG00000198586 E022 13.5686412 0.0018603393 0.5223685941 0.84126555 2 171053761 171053781 21 - 1.193 1.132 -0.215
ENSG00000198586 E023 16.4057014 0.0016984734 0.2845157203 0.68724131 2 171053782 171053853 72 - 1.285 1.193 -0.325
ENSG00000198586 E024 0.2669773 0.0274424043 0.7176052862   2 171053854 171055082 1229 - 0.096 0.148 0.714
ENSG00000198586 E025 19.8513797 0.0081700545 0.7689415235 0.93916563 2 171055083 171055172 90 - 1.322 1.343 0.073
ENSG00000198586 E026 19.4239478 0.0016456245 0.5543491305 0.85565043 2 171056471 171056566 96 - 1.301 1.344 0.148
ENSG00000198586 E027 13.5288436 0.0019516120 0.3105248359 0.70858338 2 171058151 171058197 47 - 1.126 1.215 0.316
ENSG00000198586 E028 0.0000000       2 171059924 171059986 63 -      
ENSG00000198586 E029 17.9622702 0.0028147566 0.5830207465 0.86812641 2 171061081 171061156 76 - 1.301 1.256 -0.160
ENSG00000198586 E030 0.0000000       2 171066842 171066973 132 -      
ENSG00000198586 E031 1.2700256 0.0126908124 0.9855820489   2 171081640 171081708 69 - 0.350 0.346 -0.026
ENSG00000198586 E032 15.3438367 0.0191984637 0.3711345800 0.75401613 2 171082781 171082852 72 - 1.248 1.156 -0.326
ENSG00000198586 E033 0.1812101 0.0386345439 0.7442620840   2 171091614 171091810 197 - 0.096 0.000 -10.285
ENSG00000198586 E034 8.4681531 0.1677581159 0.5728237578 0.86349294 2 171117739 171117751 13 - 1.006 0.915 -0.341
ENSG00000198586 E035 14.6597972 0.0056919459 0.4012502011 0.77415834 2 171117752 171117857 106 - 1.220 1.145 -0.268
ENSG00000198586 E036 0.0000000       2 171153851 171153924 74 -      
ENSG00000198586 E037 0.1717682 0.0460134672 0.3082832660   2 171154430 171154504 75 - 0.000 0.148 10.351
ENSG00000198586 E038 0.2250332 0.0447068898 0.3895083632   2 171155590 171155770 181 - 0.174 0.000 -11.202
ENSG00000198586 E039 0.0000000       2 171159588 171159827 240 -      
ENSG00000198586 E040 22.4829308 0.0044792981 0.0252389203 0.25952900 2 171160290 171161009 720 - 1.431 1.256 -0.610
ENSG00000198586 E041 0.0000000       2 171231145 171231314 170 -