ENSG00000198176

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000375370 ENSG00000198176 HEK293_DMSO_6hA HEK293_OSMI2_6hA TFDP1 protein_coding protein_coding 110.6067 55.78127 82.75047 1.603082 12.94209 0.5689023 25.314059 10.826681 7.4938851 1.386312 1.9293219 -0.5302134 0.21302083 0.1929667 0.08916667 -0.10380000 1.515223e-02 4.195464e-30 FALSE TRUE
ENST00000464794 ENSG00000198176 HEK293_DMSO_6hA HEK293_OSMI2_6hA TFDP1 protein_coding processed_transcript 110.6067 55.78127 82.75047 1.603082 12.94209 0.5689023 27.977525 14.769777 29.7680705 2.531591 7.0792464 1.0106258 0.25837500 0.2673000 0.34953333 0.08223333 6.289918e-01 4.195464e-30   FALSE
MSTRG.9109.17 ENSG00000198176 HEK293_DMSO_6hA HEK293_OSMI2_6hA TFDP1 protein_coding   110.6067 55.78127 82.75047 1.603082 12.94209 0.5689023 6.154572 6.061764 0.8800982 0.643638 0.8800982 -2.7700792 0.06029167 0.1085333 0.01490000 -0.09363333 2.446969e-01 4.195464e-30 FALSE TRUE
MSTRG.9109.19 ENSG00000198176 HEK293_DMSO_6hA HEK293_OSMI2_6hA TFDP1 protein_coding   110.6067 55.78127 82.75047 1.603082 12.94209 0.5689023 16.449661 10.536589 18.8167725 1.409927 1.8000753 0.8360092 0.16286667 0.1880333 0.23703333 0.04900000 7.116786e-01 4.195464e-30 FALSE TRUE
MSTRG.9109.6 ENSG00000198176 HEK293_DMSO_6hA HEK293_OSMI2_6hA TFDP1 protein_coding   110.6067 55.78127 82.75047 1.603082 12.94209 0.5689023 7.210339 0.000000 4.9036618 0.000000 1.2694375 8.9406547 0.05595833 0.0000000 0.05810000 0.05810000 4.195464e-30 4.195464e-30 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000198176 E001 0.0000000       13 113584396 113584569 174 +      
ENSG00000198176 E002 0.0000000       13 113584570 113584588 19 +      
ENSG00000198176 E003 0.1812101 0.0399734127 0.550971495   13 113584589 113584633 45 + 0.113 0.000 -9.165
ENSG00000198176 E004 13.6700235 0.0058273316 0.001512774 0.06864190 13 113584634 113584720 87 + 1.294 0.976 -1.143
ENSG00000198176 E005 16.5396686 0.0026407304 0.002434765 0.08835531 13 113584721 113584730 10 + 1.356 1.085 -0.957
ENSG00000198176 E006 0.9205636 0.0265362932 0.007692434   13 113584731 113584732 2 + 0.486 0.000 -13.950
ENSG00000198176 E007 1.5843422 0.0220387837 0.042170042   13 113584733 113584742 10 + 0.595 0.224 -2.119
ENSG00000198176 E008 2.5338917 0.0698652400 0.433589891 0.79372028 13 113584743 113584752 10 + 0.649 0.481 -0.770
ENSG00000198176 E009 17.5523645 0.0374615997 0.407975962 0.77888499 13 113584753 113584798 46 + 1.327 1.213 -0.400
ENSG00000198176 E010 101.0823272 0.0296175504 0.113744818 0.48197721 13 113584799 113584888 90 + 2.077 1.928 -0.499
ENSG00000198176 E011 0.3485388 0.0314727598 0.913383370   13 113584993 113585000 8 + 0.113 0.127 0.184
ENSG00000198176 E012 2.3184441 0.0111687873 0.783306829 0.94309301 13 113585001 113585047 47 + 0.489 0.527 0.185
ENSG00000198176 E013 2.3134417 0.0278767805 0.444544628 0.80031099 13 113585048 113585064 17 + 0.445 0.569 0.600
ENSG00000198176 E014 1.3094092 0.0126994188 0.448385678   13 113585065 113585106 42 + 0.444 0.304 -0.809
ENSG00000198176 E015 1.1326386 0.0169891210 0.638951761   13 113585107 113585149 43 + 0.394 0.304 -0.543
ENSG00000198176 E016 1.3377958 0.0119183282 0.025304605   13 113585246 113585250 5 + 0.528 0.127 -2.812
ENSG00000198176 E017 2.1718782 0.0089909489 0.058454691 0.36760776 13 113585251 113585272 22 + 0.630 0.304 -1.687
ENSG00000198176 E018 1.9951076 0.0175074432 0.095700501 0.44962955 13 113585273 113585285 13 + 0.598 0.304 -1.547
ENSG00000198176 E019 5.5099688 0.0039971632 0.470806672 0.81419198 13 113585286 113585332 47 + 0.860 0.758 -0.398
ENSG00000198176 E020 12.6141117 0.0028338335 0.077970497 0.41355744 13 113585333 113585425 93 + 1.223 1.047 -0.632
ENSG00000198176 E021 9.0547791 0.0453220280 0.301194149 0.70076615 13 113585426 113585427 2 + 1.089 0.924 -0.610
ENSG00000198176 E022 2.4136532 0.0080664238 0.971375383 0.99327255 13 113585428 113585579 152 + 0.529 0.527 -0.007
ENSG00000198176 E023 12.2212586 0.0546330532 0.302663257 0.70197980 13 113585580 113585677 98 + 1.212 1.034 -0.640
ENSG00000198176 E024 146.4390857 0.0167359449 0.045316150 0.33099546 13 113585774 113585799 26 + 2.235 2.090 -0.487
ENSG00000198176 E025 265.6626104 0.0138768802 0.051561094 0.34864069 13 113585800 113585849 50 + 2.482 2.361 -0.406
ENSG00000198176 E026 218.2380810 0.0458833025 0.163439642 0.55835495 13 113585966 113586180 215 + 2.407 2.262 -0.485
ENSG00000198176 E027 166.6142302 0.0024128944 0.876259635 0.97031085 13 113610996 113611062 67 + 2.230 2.216 -0.046
ENSG00000198176 E028 255.3180395 0.0053261827 0.889807530 0.97357356 13 113623180 113623286 107 + 2.414 2.401 -0.045
ENSG00000198176 E029 325.4234635 0.0060122970 0.552714532 0.85509611 13 113631623 113631744 122 + 2.528 2.497 -0.103
ENSG00000198176 E030 4.1163739 0.1631184776 0.872868603 0.96907157 13 113631745 113631905 161 + 0.718 0.700 -0.076
ENSG00000198176 E031 415.2600263 0.0004089193 0.143135651 0.52969909 13 113633120 113633285 166 + 2.609 2.627 0.061
ENSG00000198176 E032 0.9975704 0.3818981244 0.495471396   13 113633286 113633287 2 + 0.210 0.367 1.093
ENSG00000198176 E033 351.0887383 0.0001117254 0.002770155 0.09440364 13 113633890 113634033 144 + 2.523 2.569 0.151
ENSG00000198176 E034 215.3201361 0.0003458235 0.012274126 0.19131034 13 113634534 113634602 69 + 2.307 2.359 0.173
ENSG00000198176 E035 341.2039857 0.0005461449 0.750992831 0.93280377 13 113635977 113636128 152 + 2.535 2.532 -0.009
ENSG00000198176 E036 417.9376691 0.0001081384 0.907757663 0.97810087 13 113636534 113636700 167 + 2.628 2.616 -0.040
ENSG00000198176 E037 15.9095528 0.0729849483 0.004393390 0.11879817 13 113637151 113637242 92 + 0.971 1.384 1.477
ENSG00000198176 E038 29.9374551 0.1070007341 0.071342705 0.39841365 13 113637620 113637817 198 + 1.336 1.604 0.922
ENSG00000198176 E039 291.9396347 0.0001467067 0.994707440 0.99861307 13 113637818 113637884 67 + 2.472 2.462 -0.035
ENSG00000198176 E040 165.5307536 0.0019558312 0.898317864 0.97570464 13 113637885 113637896 12 + 2.228 2.221 -0.024
ENSG00000198176 E041 1413.3194700 0.0015478006 0.004024238 0.11348748 13 113640120 113641473 1354 + 3.130 3.170 0.131