ENSG00000197381

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000360697 ENSG00000197381 HEK293_DMSO_6hA HEK293_OSMI2_6hA ADARB1 protein_coding protein_coding 13.97086 19.07705 17.31329 2.637326 1.532704 -0.1398812 1.9858294 4.773728 1.997222 0.5811463 1.15133455 -1.25293552 0.1364500 0.25130000 0.10836667 -0.142933333 5.669666e-01 8.178608e-14 FALSE TRUE
ENST00000389863 ENSG00000197381 HEK293_DMSO_6hA HEK293_OSMI2_6hA ADARB1 protein_coding protein_coding 13.97086 19.07705 17.31329 2.637326 1.532704 -0.1398812 1.4070451 1.798658 1.723509 0.1913092 0.04425818 -0.06122431 0.1021708 0.09633333 0.10060000 0.004266667 9.440321e-01 8.178608e-14 FALSE TRUE
ENST00000462214 ENSG00000197381 HEK293_DMSO_6hA HEK293_OSMI2_6hA ADARB1 protein_coding processed_transcript 13.97086 19.07705 17.31329 2.637326 1.532704 -0.1398812 1.5514825 1.369628 1.765727 0.3219238 0.24612226 0.36413081 0.1158708 0.07150000 0.10250000 0.031000000 6.995818e-01 8.178608e-14   FALSE
ENST00000631642 ENSG00000197381 HEK293_DMSO_6hA HEK293_OSMI2_6hA ADARB1 protein_coding processed_transcript 13.97086 19.07705 17.31329 2.637326 1.532704 -0.1398812 0.7921091 1.518396 1.414217 0.4823712 0.25667932 -0.10184953 0.0525750 0.07626667 0.08323333 0.006966667 9.612259e-01 8.178608e-14   FALSE
MSTRG.21480.10 ENSG00000197381 HEK293_DMSO_6hA HEK293_OSMI2_6hA ADARB1 protein_coding   13.97086 19.07705 17.31329 2.637326 1.532704 -0.1398812 0.9146462 0.000000 2.473286 0.0000000 0.58543872 7.95610670 0.0664750 0.00000000 0.14843333 0.148433333 8.178608e-14 8.178608e-14 FALSE TRUE
MSTRG.21480.31 ENSG00000197381 HEK293_DMSO_6hA HEK293_OSMI2_6hA ADARB1 protein_coding   13.97086 19.07705 17.31329 2.637326 1.532704 -0.1398812 1.7087399 2.940964 1.665322 0.9563982 0.84753377 -0.81674780 0.1172042 0.14766667 0.09060000 -0.057066667 7.043308e-01 8.178608e-14 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000197381 E001 0.000000       21 45072423 45072847 425 +      
ENSG00000197381 E002 0.000000       21 45072848 45073458 611 +      
ENSG00000197381 E003 2.257643 0.0731793811 0.9185224354 0.98039508 21 45073459 45073852 394 + 0.524 0.494 -0.146
ENSG00000197381 E004 8.904037 0.0026409801 0.7142913929 0.92018493 21 45073853 45073903 51 + 1.012 0.977 -0.127
ENSG00000197381 E005 0.000000       21 45074569 45074579 11 +      
ENSG00000197381 E006 0.000000       21 45074580 45074589 10 +      
ENSG00000197381 E007 0.000000       21 45074590 45074590 1 +      
ENSG00000197381 E008 0.000000       21 45074591 45074599 9 +      
ENSG00000197381 E009 1.525924 0.0110684269 0.6364774822   21 45074600 45074711 112 + 0.366 0.450 0.461
ENSG00000197381 E010 1.994784 0.0106055529 0.9180256846 0.98032530 21 45074712 45074716 5 + 0.475 0.495 0.099
ENSG00000197381 E011 5.712605 0.0394389139 0.7343508734 0.92726807 21 45074717 45074754 38 + 0.795 0.851 0.219
ENSG00000197381 E012 9.698057 0.0581387405 0.7193498484 0.92195109 21 45074755 45074793 39 + 1.056 1.008 -0.173
ENSG00000197381 E013 2.285852 0.2905955072 0.6640550734 0.90189249 21 45113596 45113625 30 + 0.443 0.540 0.480
ENSG00000197381 E014 3.049089 0.2578982620 0.9753585505 0.99424417 21 45116932 45116932 1 + 0.658 0.535 -0.548
ENSG00000197381 E015 6.312294 0.1328289379 0.3024750262 0.70182355 21 45116933 45117038 106 + 0.769 0.915 0.564
ENSG00000197381 E016 4.310459 0.0574440777 0.1648684565 0.56046008 21 45118418 45118563 146 + 0.569 0.808 1.005
ENSG00000197381 E017 8.468819 0.0030579316 0.0073337413 0.15060231 21 45118564 45118619 56 + 0.776 1.087 1.175
ENSG00000197381 E018 16.278255 0.0017262604 0.0959134654 0.44992394 21 45120794 45120899 106 + 1.144 1.290 0.517
ENSG00000197381 E019 14.065922 0.0018804122 0.0366659274 0.30260123 21 45120900 45120959 60 + 1.052 1.247 0.699
ENSG00000197381 E020 41.456270 0.0007699842 0.4546638590 0.80593357 21 45128402 45128452 51 + 1.592 1.638 0.156
ENSG00000197381 E021 72.526751 0.0005036639 0.7947179274 0.94642659 21 45128453 45128573 121 + 1.847 1.863 0.053
ENSG00000197381 E022 0.871648 0.0993541260 0.2409970599   21 45132215 45132306 92 + 0.125 0.346 1.870
ENSG00000197381 E023 1.387454 0.0451972316 0.5759542911   21 45133559 45133682 124 + 0.302 0.401 0.599
ENSG00000197381 E024 28.929699 0.0244160256 0.9042604031 0.97730957 21 45134715 45134795 81 + 1.456 1.473 0.058
ENSG00000197381 E025 27.525680 0.0039295865 0.8735424318 0.96934883 21 45134796 45134832 37 + 1.431 1.448 0.056
ENSG00000197381 E026 12.460052 0.0285577780 0.3655745927 0.75058437 21 45137081 45137326 246 + 1.173 1.065 -0.390
ENSG00000197381 E027 14.235097 0.0023887674 0.5025667512 0.83103654 21 45144631 45144962 332 + 1.144 1.208 0.230
ENSG00000197381 E028 33.213130 0.0014686317 0.2103025411 0.61460357 21 45145164 45146295 1132 + 1.480 1.562 0.281
ENSG00000197381 E029 16.183819 0.0139837364 0.4396608084 0.79755590 21 45160101 45160223 123 + 1.176 1.263 0.307
ENSG00000197381 E030 42.654800 0.0006973835 0.8368173918 0.95920322 21 45171610 45171641 32 + 1.635 1.629 -0.019
ENSG00000197381 E031 46.029782 0.0006920663 0.8782551133 0.97083376 21 45171642 45171684 43 + 1.660 1.673 0.044
ENSG00000197381 E032 1.524608 0.0701763937 0.4145640969   21 45171685 45171759 75 + 0.303 0.450 0.851
ENSG00000197381 E033 243.008479 0.0037782259 0.3735120976 0.75554976 21 45175730 45176409 680 + 2.397 2.370 -0.089
ENSG00000197381 E034 136.820060 0.0046474391 0.1338587430 0.51598312 21 45176410 45176664 255 + 2.166 2.107 -0.198
ENSG00000197381 E035 4.026355 0.0314081147 0.2987001935 0.69890143 21 45177067 45177547 481 + 0.601 0.766 0.692
ENSG00000197381 E036 83.775636 0.0007838624 0.0917514331 0.44163288 21 45180330 45180435 106 + 1.955 1.894 -0.206
ENSG00000197381 E037 47.373061 0.0006934369 0.4653962347 0.81134899 21 45180436 45180444 9 + 1.699 1.667 -0.108
ENSG00000197381 E038 14.780431 0.1515320709 0.1587941284 0.55242408 21 45181070 45181232 163 + 1.049 1.286 0.846
ENSG00000197381 E039 11.000156 0.3941914407 0.3143303008 0.71174125 21 45181322 45181479 158 + 1.002 1.127 0.458
ENSG00000197381 E040 7.614025 0.0600306865 0.1595944423 0.55374349 21 45181480 45181516 37 + 0.804 1.014 0.796
ENSG00000197381 E041 120.671570 0.0002910447 0.5682394936 0.86152775 21 45182585 45182753 169 + 2.084 2.071 -0.043
ENSG00000197381 E042 120.475190 0.0012278841 0.0351158987 0.29767856 21 45183362 45183510 149 + 2.111 2.040 -0.236
ENSG00000197381 E043 98.204979 0.0040977529 0.0093256840 0.16809659 21 45184474 45184593 120 + 2.048 1.927 -0.403
ENSG00000197381 E044 128.702997 0.0004315142 0.0002863404 0.02563435 21 45184923 45185091 169 + 2.163 2.054 -0.365
ENSG00000197381 E045 124.631906 0.0049164029 0.0893760778 0.43740167 21 45204555 45204736 182 + 2.136 2.062 -0.247
ENSG00000197381 E046 133.579831 0.0019521491 0.1276383211 0.50669783 21 45220836 45220970 135 + 2.151 2.101 -0.169
ENSG00000197381 E047 79.508036 0.0003507487 0.3108224000 0.70873735 21 45220971 45221014 44 + 1.917 1.882 -0.116
ENSG00000197381 E048 127.965895 0.0002325755 0.5916486436 0.87207136 21 45222018 45222107 90 + 2.090 2.112 0.073
ENSG00000197381 E049 65.437562 0.0004372841 0.2737147437 0.67751615 21 45222108 45222111 4 + 1.837 1.794 -0.143
ENSG00000197381 E050 93.807851 0.0003245616 0.4846217130 0.82190815 21 45222112 45222280 169 + 1.980 1.959 -0.069
ENSG00000197381 E051 108.993979 0.0003179705 0.0782245728 0.41409966 21 45222281 45222760 480 + 1.996 2.061 0.216
ENSG00000197381 E052 200.167809 0.0002684312 0.0699229807 0.39540809 21 45222761 45223577 817 + 2.268 2.318 0.168
ENSG00000197381 E053 323.151419 0.0087616699 0.3132028504 0.71071244 21 45223578 45225546 1969 + 2.490 2.521 0.106
ENSG00000197381 E054 412.393056 0.0011772543 0.0003613768 0.02949921 21 45225547 45226560 1014 + 2.566 2.644 0.260