ENSG00000197170

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000356126 ENSG00000197170 HEK293_DMSO_6hA HEK293_OSMI2_6hA PSMD12 protein_coding protein_coding 53.67628 16.40639 28.37576 5.660818 6.387209 0.7900303 10.588331 3.090992 2.388981 0.8211037 0.490518 -0.3703081 0.1851125 0.20150000 0.08656667 -0.11493333 0.03631739 0.03631739 FALSE TRUE
ENST00000584289 ENSG00000197170 HEK293_DMSO_6hA HEK293_OSMI2_6hA PSMD12 protein_coding retained_intron 53.67628 16.40639 28.37576 5.660818 6.387209 0.7900303 11.459514 1.581649 7.697298 1.0403916 2.136675 2.2757026 0.1947250 0.07596667 0.28020000 0.20423333 0.54414050 0.03631739 FALSE TRUE
MSTRG.14953.3 ENSG00000197170 HEK293_DMSO_6hA HEK293_OSMI2_6hA PSMD12 protein_coding   53.67628 16.40639 28.37576 5.660818 6.387209 0.7900303 4.149671 2.042714 4.873667 0.5969516 1.421213 1.2504325 0.1218792 0.12953333 0.16490000 0.03536667 0.74178344 0.03631739 FALSE TRUE
MSTRG.14953.4 ENSG00000197170 HEK293_DMSO_6hA HEK293_OSMI2_6hA PSMD12 protein_coding   53.67628 16.40639 28.37576 5.660818 6.387209 0.7900303 23.603794 8.573775 11.986869 2.8953061 2.917109 0.4829738 0.4384333 0.52823333 0.41696667 -0.11126667 0.21136355 0.03631739 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000197170 E001 132.0487882 0.0095645448 7.607075e-08 0.0000818546 17 67337916 67339802 1887 - 1.959 2.269 1.037
ENSG00000197170 E002 55.1490829 0.0051715852 2.440005e-06 0.0011017190 17 67339803 67340563 761 - 1.605 1.886 0.953
ENSG00000197170 E003 53.1655532 0.0112850619 1.733197e-01 0.5708956851 17 67340564 67340687 124 - 1.689 1.782 0.318
ENSG00000197170 E004 81.9884967 0.0085922987 4.512594e-01 0.8043162345 17 67340688 67340773 86 - 1.897 1.945 0.161
ENSG00000197170 E005 221.4860749 0.0018757817 6.279951e-03 0.1403620652 17 67340774 67340974 201 - 2.310 2.397 0.289
ENSG00000197170 E006 169.7815990 0.0002701526 3.236186e-02 0.2886326882 17 67340975 67341052 78 - 2.209 2.274 0.216
ENSG00000197170 E007 161.5242558 0.0005109101 2.146558e-01 0.6192699795 17 67342186 67342263 78 - 2.195 2.239 0.145
ENSG00000197170 E008 4.0979114 0.0130994388 3.259159e-03 0.1028512557 17 67342264 67342484 221 - 0.453 0.897 1.907
ENSG00000197170 E009 241.1431596 0.0002174115 9.047115e-01 0.9774276542 17 67344606 67344780 175 - 2.388 2.394 0.020
ENSG00000197170 E010 1.6337591 0.0108323419 2.418917e-01 0.6469734900 17 67345612 67345744 133 - 0.312 0.518 1.131
ENSG00000197170 E011 175.7222295 0.0002364192 9.771591e-02 0.4530906971 17 67345745 67345857 113 - 2.268 2.233 -0.116
ENSG00000197170 E012 164.3745388 0.0012931779 2.089904e-01 0.6131795372 17 67347116 67347250 135 - 2.240 2.209 -0.103
ENSG00000197170 E013 194.7999885 0.0002302318 2.298270e-03 0.0853527449 17 67347336 67347485 150 - 2.328 2.260 -0.226
ENSG00000197170 E014 175.2437949 0.0002592245 9.940213e-03 0.1729913176 17 67348550 67348654 105 - 2.278 2.218 -0.200
ENSG00000197170 E015 116.2993834 0.0003027614 1.486658e-02 0.2076472142 17 67350229 67350257 29 - 2.105 2.034 -0.237
ENSG00000197170 E016 128.9000960 0.0009328775 6.003078e-02 0.3716798644 17 67350258 67350298 41 - 2.144 2.091 -0.176
ENSG00000197170 E017 98.1717340 0.0032637693 3.848614e-01 0.7635640791 17 67350299 67350336 38 - 2.017 1.986 -0.103
ENSG00000197170 E018 0.9099321 0.0282993295 4.042943e-02   17 67355341 67355422 82 - 0.101 0.464 2.871
ENSG00000197170 E019 0.1812101 0.0402999991 6.721019e-01   17 67357152 67357302 151 - 0.101 0.000 -8.479
ENSG00000197170 E020 146.8295407 0.0025223732 1.627703e-02 0.2163363783 17 67357303 67357431 129 - 2.206 2.129 -0.259
ENSG00000197170 E021 2.1435247 0.0318873217 1.762367e-02 0.2241634072 17 67357432 67357518 87 - 0.253 0.683 2.269
ENSG00000197170 E022 88.2218941 0.0019975939 1.835993e-03 0.0762737880 17 67357519 67357578 60 - 2.004 1.883 -0.409
ENSG00000197170 E023 0.3356707 0.0267614478 7.966099e-01   17 67361095 67361261 167 - 0.101 0.141 0.544
ENSG00000197170 E024 0.7749791 0.1706763136 8.684463e-01   17 67362776 67362892 117 - 0.253 0.246 -0.058
ENSG00000197170 E025 97.0853833 0.0112542567 2.291455e-02 0.2496808819 17 67366412 67366605 194 - 2.042 1.924 -0.395