ENSG00000196776

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000355354 ENSG00000196776 HEK293_DMSO_6hA HEK293_OSMI2_6hA CD47 protein_coding protein_coding 35.30564 18.84308 12.14611 2.759769 0.8338621 -0.6331188 5.793501 2.492314 1.549849 0.5181251 0.1188275 -0.6818566 0.1532042 0.13056667 0.1299333 -0.0006333333 9.937166e-01 2.475111e-16 FALSE TRUE
ENST00000517766 ENSG00000196776 HEK293_DMSO_6hA HEK293_OSMI2_6hA CD47 protein_coding protein_coding 35.30564 18.84308 12.14611 2.759769 0.8338621 -0.6331188 1.494333 3.612898 0.000000 0.6449247 0.0000000 -8.5010005 0.0563375 0.20023333 0.0000000 -0.2002333333 2.475111e-16 2.475111e-16 FALSE FALSE
MSTRG.23404.4 ENSG00000196776 HEK293_DMSO_6hA HEK293_OSMI2_6hA CD47 protein_coding   35.30564 18.84308 12.14611 2.759769 0.8338621 -0.6331188 17.152288 9.682555 6.323451 1.6160097 0.2771644 -0.6138851 0.4796833 0.51086667 0.5224333 0.0115666667 9.308719e-01 2.475111e-16 FALSE TRUE
MSTRG.23404.5 ENSG00000196776 HEK293_DMSO_6hA HEK293_OSMI2_6hA CD47 protein_coding   35.30564 18.84308 12.14611 2.759769 0.8338621 -0.6331188 7.475982 1.236570 3.023093 0.7937139 0.5722575 1.2828256 0.2100417 0.05973333 0.2454000 0.1856666667 3.340598e-01 2.475111e-16 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000196776 E001 0.3340335 0.0274424043 3.771166e-01   3 108043091 108043297 207 - 0.000 0.178 9.574
ENSG00000196776 E002 238.2985182 0.0155041835 3.326771e-01 0.726690307 3 108043298 108047066 3769 - 2.309 2.389 0.268
ENSG00000196776 E003 6.6392183 0.0037637439 4.211197e-01 0.786853587 3 108047067 108047067 1 - 0.790 0.908 0.456
ENSG00000196776 E004 7.8356090 0.0097841026 4.588237e-01 0.807898572 3 108047068 108047078 11 - 0.865 0.971 0.399
ENSG00000196776 E005 162.7829569 0.0022215269 2.291940e-01 0.634291995 3 108047079 108047292 214 - 2.156 2.215 0.199
ENSG00000196776 E006 9.9029453 0.0029970020 9.385033e-01 0.985605762 3 108049619 108049651 33 - 1.006 1.015 0.033
ENSG00000196776 E007 13.4671467 0.0062306229 7.530868e-01 0.933529793 3 108050578 108050602 25 - 1.150 1.135 -0.051
ENSG00000196776 E008 95.7238757 0.0044652632 6.149475e-01 0.882254517 3 108051939 108051970 32 - 1.941 1.980 0.132
ENSG00000196776 E009 65.4569849 0.0366546514 6.631833e-02 0.387420484 3 108051971 108054739 2769 - 1.684 1.860 0.594
ENSG00000196776 E010 3.4590357 0.0262744861 3.084715e-01 0.706790543 3 108055520 108055566 47 - 0.730 0.578 -0.650
ENSG00000196776 E011 121.5515290 0.0035462840 4.568181e-01 0.807030392 3 108057477 108057533 57 - 2.038 2.083 0.150
ENSG00000196776 E012 99.7530959 0.0036485866 3.073099e-01 0.705611983 3 108057534 108057569 36 - 1.944 2.004 0.201
ENSG00000196776 E013 113.1252306 0.0007919901 5.230704e-01 0.841659661 3 108058337 108058385 49 - 2.009 2.050 0.138
ENSG00000196776 E014 92.2797455 0.0003453010 7.752521e-01 0.940994319 3 108058386 108058429 44 - 1.943 1.952 0.030
ENSG00000196776 E015 60.4501603 0.0007660352 7.209267e-01 0.922601964 3 108059452 108059456 5 - 1.750 1.786 0.123
ENSG00000196776 E016 113.7740550 0.0002832432 2.178915e-01 0.622480880 3 108059457 108059544 88 - 2.055 2.034 -0.069
ENSG00000196776 E017 136.8562200 0.0003086717 3.431067e-02 0.295033313 3 108060745 108060852 108 - 2.146 2.102 -0.147
ENSG00000196776 E018 102.6291819 0.0003566634 1.265894e-01 0.505044072 3 108071093 108071182 90 - 2.017 1.984 -0.112
ENSG00000196776 E019 185.8166723 0.0001875935 1.195294e-04 0.014854054 3 108079991 108080344 354 - 2.297 2.220 -0.256
ENSG00000196776 E020 30.7182410 0.0013267707 6.339585e-06 0.002202361 3 108090863 108091048 186 - 1.627 1.362 -0.910
ENSG00000196776 E021 0.0000000       3 108091737 108091862 126 -