ENSG00000188706

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000357166 ENSG00000188706 HEK293_DMSO_6hA HEK293_OSMI2_6hA ZDHHC9 protein_coding protein_coding 47.15648 47.34854 74.44873 4.379757 7.320453 0.6528162 15.971187 16.592284 22.889121 1.6662570 2.0282028 0.4639105 0.3243542 0.35010000 0.30810000 -0.04200000 0.361106547 0.001260364 FALSE TRUE
ENST00000371064 ENSG00000188706 HEK293_DMSO_6hA HEK293_OSMI2_6hA ZDHHC9 protein_coding protein_coding 47.15648 47.34854 74.44873 4.379757 7.320453 0.6528162 5.417349 7.759955 6.810028 0.9408259 0.2710510 -0.1881285 0.1127667 0.16330000 0.09266667 -0.07063333 0.001260364 0.001260364 FALSE TRUE
MSTRG.34859.15 ENSG00000188706 HEK293_DMSO_6hA HEK293_OSMI2_6hA ZDHHC9 protein_coding   47.15648 47.34854 74.44873 4.379757 7.320453 0.6528162 4.832231 1.938967 8.695761 0.6828038 0.3620915 2.1592610 0.1185333 0.04016667 0.11883333 0.07866667 0.006884645 0.001260364 FALSE FALSE
MSTRG.34859.3 ENSG00000188706 HEK293_DMSO_6hA HEK293_OSMI2_6hA ZDHHC9 protein_coding   47.15648 47.34854 74.44873 4.379757 7.320453 0.6528162 8.995727 9.524911 18.436101 1.2115337 2.6285331 0.9520246 0.1919333 0.20306667 0.24580000 0.04273333 0.668483832 0.001260364 FALSE TRUE
MSTRG.34859.4 ENSG00000188706 HEK293_DMSO_6hA HEK293_OSMI2_6hA ZDHHC9 protein_coding   47.15648 47.34854 74.44873 4.379757 7.320453 0.6528162 6.772510 6.788290 13.030509 0.8236210 3.2201866 0.9397565 0.1434167 0.14283333 0.17020000 0.02736667 0.747961452 0.001260364 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000188706 E001 1081.442614 0.0008605800 3.486691e-02 0.297076568 X 129803288 129805328 2041 - 3.012 3.049 0.123
ENSG00000188706 E002 2379.064870 0.0008250363 3.168932e-01 0.714070799 X 129805329 129806486 1158 - 3.367 3.381 0.047
ENSG00000188706 E003 441.739173 0.0004986203 4.499184e-01 0.803472117 X 129810905 129810986 82 - 2.630 2.648 0.059
ENSG00000188706 E004 253.803921 0.0001394048 7.086806e-01 0.918262513 X 129810987 129811001 15 - 2.392 2.404 0.039
ENSG00000188706 E005 363.333370 0.0001073916 5.457997e-01 0.852311697 X 129811406 129811446 41 - 2.546 2.561 0.049
ENSG00000188706 E006 464.377079 0.0001073868 2.602313e-02 0.262323006 X 129811447 129811509 63 - 2.642 2.681 0.133
ENSG00000188706 E007 516.470997 0.0001761022 8.969972e-03 0.164899619 X 129812718 129812820 103 - 2.684 2.729 0.150
ENSG00000188706 E008 24.922833 0.0051282892 9.157943e-02 0.441239630 X 129813661 129813676 16 - 1.339 1.468 0.446
ENSG00000188706 E009 401.258531 0.0016415174 1.972531e-01 0.600539080 X 129813677 129813725 49 - 2.581 2.615 0.112
ENSG00000188706 E010 511.653839 0.0001236587 4.535855e-01 0.805353794 X 129814658 129814770 113 - 2.705 2.696 -0.031
ENSG00000188706 E011 252.049882 0.0001652409 7.731517e-02 0.411982114 X 129814771 129814795 25 - 2.413 2.375 -0.124
ENSG00000188706 E012 8.202866 0.0894860724 6.149294e-01 0.882248623 X 129822888 129823402 515 - 0.932 0.989 0.212
ENSG00000188706 E013 441.634369 0.0001234038 2.857506e-03 0.095814355 X 129823679 129823837 159 - 2.660 2.612 -0.161
ENSG00000188706 E014 462.499989 0.0013186971 4.119724e-02 0.317982300 X 129828981 129829141 161 - 2.679 2.634 -0.151
ENSG00000188706 E015 436.181686 0.0012200054 5.643161e-01 0.859631924 X 129841779 129841918 140 - 2.638 2.627 -0.035
ENSG00000188706 E016 218.516738 0.0027835347 9.867520e-01 0.996730462 X 129841919 129841930 12 - 2.333 2.335 0.007
ENSG00000188706 E017 251.078171 0.0014754315 7.229183e-01 0.923153205 X 129841931 129841956 26 - 2.388 2.400 0.039
ENSG00000188706 E018 492.342317 0.0001279509 7.372989e-02 0.403610948 X 129841957 129842080 124 - 2.696 2.670 -0.087
ENSG00000188706 E019 390.828377 0.0014334146 2.417663e-02 0.255079871 X 129843259 129843326 68 - 2.609 2.559 -0.169
ENSG00000188706 E020 12.693188 0.0152307888 9.621003e-01 0.991299254 X 129843327 129843460 134 - 1.130 1.127 -0.014
ENSG00000188706 E021 4.810474 0.0046484712 9.922964e-01 0.998181527 X 129843539 129843562 24 - 0.756 0.758 0.008
ENSG00000188706 E022 5.285832 0.0180031756 3.306451e-01 0.725185095 X 129843563 129843695 133 - 0.713 0.857 0.572
ENSG00000188706 E023 387.180107 0.0008552853 3.684714e-05 0.007191876 X 129843696 129843909 214 - 2.622 2.533 -0.297