ENSG00000188191

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000403562 ENSG00000188191 HEK293_DMSO_6hA HEK293_OSMI2_6hA PRKAR1B protein_coding protein_coding 26.02378 17.14861 38.2992 3.150159 8.088487 1.158759 9.0815718 5.4847879 13.43470 0.8261118 2.186559 1.290901 0.3493333 0.32663333 0.3610000 0.03436667 7.521776e-01 2.499286e-13 FALSE TRUE
ENST00000430040 ENSG00000188191 HEK293_DMSO_6hA HEK293_OSMI2_6hA PRKAR1B protein_coding protein_coding 26.02378 17.14861 38.2992 3.150159 8.088487 1.158759 0.7374598 0.9668932 0.00000 0.1077403 0.000000 -6.610129 0.0538750 0.05906667 0.0000000 -0.05906667 2.499286e-13 2.499286e-13 FALSE TRUE
ENST00000537384 ENSG00000188191 HEK293_DMSO_6hA HEK293_OSMI2_6hA PRKAR1B protein_coding protein_coding 26.02378 17.14861 38.2992 3.150159 8.088487 1.158759 14.4557751 8.8721179 23.44581 1.4824964 6.097580 1.400970 0.5253667 0.52076667 0.5949667 0.07420000 5.108705e-01 2.499286e-13 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000188191 E001 0.5297488 0.0277396394 1.000000e+00   7 549197 549197 1 - 0.157 0.165 0.084
ENSG00000188191 E002 92.0443379 0.0067177110 7.082318e-01 0.918083263 7 549198 549408 211 - 1.960 1.933 -0.091
ENSG00000188191 E003 179.9931435 0.0003668799 6.148315e-02 0.375512613 7 549409 549536 128 - 2.260 2.203 -0.188
ENSG00000188191 E004 227.6910479 0.0007382061 3.830543e-03 0.110758226 7 549537 549739 203 - 2.370 2.288 -0.272
ENSG00000188191 E005 78.8702837 0.0013792833 1.187499e-02 0.188323803 7 549740 549741 2 - 1.922 1.803 -0.401
ENSG00000188191 E006 86.3886500 0.0014569807 5.366704e-03 0.130935096 7 549742 549749 8 - 1.964 1.836 -0.430
ENSG00000188191 E007 396.3116392 0.0003120561 7.594416e-02 0.408942107 7 549750 550269 520 - 2.594 2.558 -0.122
ENSG00000188191 E008 245.9357714 0.0015947678 2.141063e-01 0.618554717 7 550270 550602 333 - 2.386 2.350 -0.119
ENSG00000188191 E009 131.6185649 0.0002323473 4.577859e-01 0.807461244 7 551389 551470 82 - 2.114 2.087 -0.092
ENSG00000188191 E010 230.7726056 0.0001481343 7.823892e-01 0.942964201 7 579256 579377 122 - 2.345 2.348 0.011
ENSG00000188191 E011 232.1720160 0.0008120845 6.179446e-01 0.883124650 7 584508 584568 61 - 2.340 2.355 0.049
ENSG00000188191 E012 188.4571426 0.0032519344 6.400225e-01 0.892289086 7 596146 596179 34 - 2.257 2.246 -0.036
ENSG00000188191 E013 341.9496670 0.0001282200 6.714264e-01 0.904725076 7 596180 596304 125 - 2.514 2.519 0.018
ENSG00000188191 E014 0.0000000       7 602553 602683 131 -      
ENSG00000188191 E015 258.3511297 0.0001517312 5.741053e-02 0.364695301 7 606193 606239 47 - 2.381 2.420 0.132
ENSG00000188191 E016 172.9047228 0.0024128847 7.166022e-03 0.149049114 7 607391 607395 5 - 2.184 2.279 0.319
ENSG00000188191 E017 251.0602629 0.0003022893 6.956754e-04 0.044300535 7 607396 607452 57 - 2.356 2.432 0.254
ENSG00000188191 E018 255.2585253 0.0001698779 1.004477e-03 0.054271576 7 677229 677320 92 - 2.365 2.436 0.237
ENSG00000188191 E019 242.6579143 0.0008319920 5.733049e-01 0.863621111 7 680556 680726 171 - 2.359 2.376 0.059
ENSG00000188191 E020 0.0000000       7 691540 691794 255 -      
ENSG00000188191 E021 1.6456429 0.3189602948 8.844078e-01 0.972316386 7 696713 697102 390 - 0.433 0.376 -0.315
ENSG00000188191 E022 182.6079618 0.0053421647 4.290023e-01 0.791333599 7 711329 711527 199 - 2.248 2.232 -0.055
ENSG00000188191 E023 0.1795728 0.0330573019 2.302571e-01   7 712414 712572 159 - 0.000 0.165 9.535
ENSG00000188191 E024 1.1144906 0.3256923138 8.136403e-01   7 712848 712921 74 - 0.320 0.287 -0.221
ENSG00000188191 E025 1.5127781 0.4860584759 6.252883e-01   7 712922 713054 133 - 0.330 0.458 0.718
ENSG00000188191 E026 1.6343220 0.4211118632 4.003978e-01 0.773556767 7 713055 713207 153 - 0.329 0.516 1.009
ENSG00000188191 E027 4.2823993 0.0054086242 1.350368e-04 0.016198841 7 716619 716683 65 - 0.438 0.970 2.259
ENSG00000188191 E028 11.7006739 0.0023289096 2.258832e-06 0.001052815 7 716684 716846 163 - 0.863 1.320 1.659
ENSG00000188191 E029 2.5511309 0.1392887437 1.083002e-01 0.472494925 7 725237 725297 61 - 0.369 0.715 1.645
ENSG00000188191 E030 1.4263652 0.0118097257 9.157477e-01   7 726604 727209 606 - 0.401 0.378 -0.128
ENSG00000188191 E031 38.1068798 0.0443623902 3.010061e-01 0.700702384 7 727210 727341 132 - 1.596 1.519 -0.265
ENSG00000188191 E032 33.8639672 0.0008175073 4.944322e-03 0.126204341 7 727590 727650 61 - 1.579 1.391 -0.646