ENSG00000187792

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000341976 ENSG00000187792 HEK293_DMSO_6hA HEK293_OSMI2_6hA ZNF70 protein_coding protein_coding 4.092365 5.111543 6.201844 0.235982 0.2092453 0.2784431 1.9615480 3.3921570 2.9511287 0.02697464 0.1955115 -0.2003025 0.45964583 0.66680000 0.47836667 -0.18843333 0.14517890 0.03938558 FALSE TRUE
MSTRG.21783.1 ENSG00000187792 HEK293_DMSO_6hA HEK293_OSMI2_6hA ZNF70 protein_coding   4.092365 5.111543 6.201844 0.235982 0.2092453 0.2784431 0.3626339 0.1671316 0.1845302 0.12907896 0.1845302 0.1351722 0.09844583 0.03060000 0.02920000 -0.00140000 0.80201971 0.03938558 TRUE TRUE
MSTRG.21783.3 ENSG00000187792 HEK293_DMSO_6hA HEK293_OSMI2_6hA ZNF70 protein_coding   4.092365 5.111543 6.201844 0.235982 0.2092453 0.2784431 1.5037077 1.0944131 2.6611272 0.17764301 0.3301231 1.2741688 0.38342083 0.21206667 0.42706667 0.21500000 0.03938558 0.03938558 TRUE TRUE
MSTRG.21783.5 ENSG00000187792 HEK293_DMSO_6hA HEK293_OSMI2_6hA ZNF70 protein_coding   4.092365 5.111543 6.201844 0.235982 0.2092453 0.2784431 0.2510735 0.4578414 0.4050582 0.05793257 0.1590863 -0.1727060 0.05459167 0.09053333 0.06536667 -0.02516667 0.75388908 0.03938558   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000187792 E001 2.335878 0.0084091258 2.245569e-02 0.2476257485 22 23731806 23731877 72 - 0.282 0.665 1.982
ENSG00000187792 E002 136.162221 0.0010874026 1.343817e-07 0.0001272472 22 23738682 23739604 923 - 2.035 2.205 0.572
ENSG00000187792 E003 28.103751 0.0009551403 1.236911e-03 0.0611842601 22 23739605 23739708 104 - 1.338 1.551 0.735
ENSG00000187792 E004 28.249239 0.0017056440 2.619981e-01 0.6672580398 22 23739709 23740232 524 - 1.417 1.491 0.255
ENSG00000187792 E005 481.245060 0.0001473791 6.074415e-01 0.8786233794 22 23740233 23743257 3025 - 2.677 2.672 -0.017
ENSG00000187792 E006 248.287214 0.0002014942 1.113104e-02 0.1826425819 22 23743258 23744439 1182 - 2.413 2.363 -0.168
ENSG00000187792 E007 39.993479 0.0012068129 3.154469e-01 0.7124977344 22 23744440 23744475 36 - 1.632 1.578 -0.183
ENSG00000187792 E008 47.023482 0.0006040223 4.327257e-02 0.3244423803 22 23744476 23744559 84 - 1.721 1.621 -0.340
ENSG00000187792 E009 81.368980 0.0005517066 5.567600e-02 0.3601831838 22 23744560 23744948 389 - 1.944 1.872 -0.243
ENSG00000187792 E010 21.662576 0.0037350868 3.284277e-01 0.7233258673 22 23744949 23744972 24 - 1.385 1.310 -0.264
ENSG00000187792 E011 35.245884 0.0008272124 1.044831e-01 0.4657962980 22 23744973 23745087 115 - 1.597 1.504 -0.316
ENSG00000187792 E012 28.495202 0.0020256578 7.747614e-01 0.9407852776 22 23745088 23745219 132 - 1.455 1.477 0.077
ENSG00000187792 E013 4.212453 0.0245532241 2.328567e-01 0.6378242932 22 23745380 23745491 112 - 0.607 0.798 0.794
ENSG00000187792 E014 15.075039 0.0019224476 2.998782e-01 0.6997969816 22 23750711 23750980 270 - 1.150 1.242 0.326
ENSG00000187792 E015 2.246047 0.1116258414 3.088145e-01 0.7071326923 22 23750981 23751112 132 - 0.586 0.367 -1.107