ENSG00000187109

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000393263 ENSG00000187109 HEK293_DMSO_6hA HEK293_OSMI2_6hA NAP1L1 protein_coding protein_coding 374.5503 150.2665 250.6492 36.73608 73.31938 0.738108 94.87228 33.28084 68.83821 8.215972 20.445020 1.0482939 0.2519333 0.2218667 0.27520000 0.05333333 0.22458512 1.016047e-06 FALSE TRUE
ENST00000547773 ENSG00000187109 HEK293_DMSO_6hA HEK293_OSMI2_6hA NAP1L1 protein_coding protein_coding 374.5503 150.2665 250.6492 36.73608 73.31938 0.738108 45.02965 18.24906 21.45960 5.409291 5.707728 0.2336824 0.1154042 0.1189000 0.08793333 -0.03096667 0.23693829 1.016047e-06 FALSE TRUE
ENST00000548044 ENSG00000187109 HEK293_DMSO_6hA HEK293_OSMI2_6hA NAP1L1 protein_coding protein_coding 374.5503 150.2665 250.6492 36.73608 73.31938 0.738108 89.08127 39.14186 89.00716 7.868886 28.368425 1.1850027 0.2535333 0.2654333 0.34583333 0.08040000 0.05507558 1.016047e-06 FALSE TRUE
MSTRG.7677.2 ENSG00000187109 HEK293_DMSO_6hA HEK293_OSMI2_6hA NAP1L1 protein_coding   374.5503 150.2665 250.6492 36.73608 73.31938 0.738108 90.79768 31.67346 35.11371 8.922149 8.779465 0.1487153 0.2293208 0.2076000 0.14436667 -0.06323333 0.04205907 1.016047e-06 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000187109 E001 141.3726219 8.185866e-03 2.794627e-04 0.0251818851 12 76036585 76046259 9675 - 2.048 2.264 0.724
ENSG00000187109 E002 816.2402530 7.764833e-03 5.566638e-06 0.0019966279 12 76046260 76046903 644 - 2.791 3.031 0.800
ENSG00000187109 E003 491.9098061 6.411361e-03 4.278062e-05 0.0080558347 12 76046904 76047154 251 - 2.585 2.802 0.722
ENSG00000187109 E004 433.7483735 7.324936e-03 1.621408e-04 0.0178983333 12 76047155 76047594 440 - 2.531 2.748 0.722
ENSG00000187109 E005 68.0627652 9.348106e-03 4.534280e-03 0.1207846298 12 76047595 76047595 1 - 1.741 1.953 0.716
ENSG00000187109 E006 193.7593389 6.232213e-03 8.769059e-02 0.4336482907 12 76047596 76047631 36 - 2.238 2.348 0.367
ENSG00000187109 E007 161.7102923 3.626870e-03 1.341988e-01 0.5165489908 12 76047632 76047633 2 - 2.174 2.259 0.283
ENSG00000187109 E008 504.8870671 1.109312e-04 1.761752e-04 0.0189447172 12 76047634 76047718 85 - 2.679 2.750 0.235
ENSG00000187109 E009 270.0623766 8.946131e-03 1.709878e-03 0.0734201662 12 76047719 76047966 248 - 2.331 2.540 0.695
ENSG00000187109 E010 141.6799684 6.905023e-03 3.202421e-03 0.1018925747 12 76047967 76048029 63 - 2.070 2.253 0.615
ENSG00000187109 E011 308.1009202 7.123678e-03 2.245074e-03 0.0843411969 12 76048030 76048392 363 - 2.403 2.582 0.596
ENSG00000187109 E012 447.2251656 9.556587e-05 1.909658e-05 0.0047319781 12 76048393 76048420 28 - 2.623 2.704 0.271
ENSG00000187109 E013 732.6462230 8.330566e-05 1.361768e-02 0.2006555731 12 76048421 76048464 44 - 2.854 2.897 0.144
ENSG00000187109 E014 16.6476916 1.083540e-01 3.352309e-03 0.1043455176 12 76048995 76049145 151 - 0.909 1.481 2.041
ENSG00000187109 E015 12.0456408 1.504313e-01 2.377955e-02 0.2536698936 12 76049146 76049199 54 - 0.833 1.327 1.803
ENSG00000187109 E016 916.3406234 1.037796e-04 3.861909e-02 0.3093803890 12 76049200 76049250 51 - 2.953 2.989 0.121
ENSG00000187109 E017 29.2277493 1.198139e-01 4.056613e-02 0.3160390240 12 76049251 76049428 178 - 1.261 1.663 1.387
ENSG00000187109 E018 10.3709868 6.283482e-02 2.079465e-02 0.2395620626 12 76049429 76049433 5 - 0.867 1.231 1.333
ENSG00000187109 E019 20.3569892 3.513686e-03 1.176670e-02 0.1875056158 12 76049434 76049464 31 - 1.231 1.438 0.724
ENSG00000187109 E020 38.9768157 9.004425e-04 3.384920e-01 0.7309179214 12 76049465 76049525 61 - 1.580 1.642 0.212
ENSG00000187109 E021 9.5960044 4.216507e-03 2.623801e-03 0.0919017890 12 76049526 76049561 36 - 0.861 1.188 1.204
ENSG00000187109 E022 23.7095309 1.108847e-03 3.728099e-01 0.7552300793 12 76049562 76049588 27 - 1.367 1.438 0.247
ENSG00000187109 E023 338.2219420 1.333724e-04 2.043444e-04 0.0206852175 12 76049589 76049755 167 - 2.564 2.499 -0.216
ENSG00000187109 E024 1180.7628898 1.069231e-04 5.555330e-01 0.8562549110 12 76049756 76049785 30 - 3.071 3.088 0.059
ENSG00000187109 E025 1754.7588997 4.410937e-04 3.507277e-01 0.7400455561 12 76050531 76050653 123 - 3.244 3.247 0.011
ENSG00000187109 E026 1099.3840530 1.293887e-03 2.362771e-01 0.6412677566 12 76053091 76053110 20 - 3.044 3.035 -0.031
ENSG00000187109 E027 129.3531033 2.976579e-04 6.544463e-01 0.8983450468 12 76053111 76053158 48 - 2.112 2.135 0.078
ENSG00000187109 E028 1634.0680260 3.314481e-04 1.431088e-01 0.5296470191 12 76053205 76053327 123 - 3.218 3.214 -0.011
ENSG00000187109 E029 794.6360854 8.544063e-05 2.206070e-01 0.6252083796 12 76053328 76053328 1 - 2.911 2.905 -0.021
ENSG00000187109 E030 952.0283280 7.531681e-05 2.941840e-02 0.2771451658 12 76053329 76053350 22 - 2.994 2.978 -0.054
ENSG00000187109 E031 923.0439755 1.462605e-04 2.140576e-02 0.2425386278 12 76053770 76053787 18 - 2.981 2.963 -0.062
ENSG00000187109 E032 1049.5486947 6.061414e-05 7.623919e-02 0.4097451587 12 76053788 76053832 45 - 3.034 3.024 -0.034
ENSG00000187109 E033 1388.2138001 5.173284e-05 1.527895e-04 0.0173665812 12 76053833 76053909 77 - 3.162 3.134 -0.092
ENSG00000187109 E034 839.8670356 6.485704e-04 3.059191e-02 0.2818187201 12 76055019 76055019 1 - 2.938 2.913 -0.086
ENSG00000187109 E035 1177.9598037 3.483538e-04 7.772336e-03 0.1545744590 12 76055020 76055047 28 - 3.085 3.062 -0.077
ENSG00000187109 E036 1087.4474205 6.521679e-04 3.207678e-02 0.2876241807 12 76055048 76055090 43 - 3.047 3.026 -0.070
ENSG00000187109 E037 1449.9680947 1.377351e-04 1.140844e-03 0.0584022627 12 76056033 76056124 92 - 3.178 3.155 -0.077
ENSG00000187109 E038 1103.7279051 6.246779e-05 1.234566e-03 0.0611111910 12 76056125 76056158 34 - 3.061 3.036 -0.085
ENSG00000187109 E039 867.9666655 6.885067e-05 4.343484e-02 0.3247408878 12 76056159 76056161 3 - 2.953 2.938 -0.050
ENSG00000187109 E040 16.9442814 2.358384e-02 7.490598e-02 0.4067481995 12 76056162 76056573 412 - 1.161 1.369 0.731
ENSG00000187109 E041 3.3778345 6.462932e-03 1.258672e-02 0.1936073804 12 76056574 76056672 99 - 0.440 0.820 1.676
ENSG00000187109 E042 9.8705982 1.939486e-01 3.208882e-02 0.2876917250 12 76056673 76057743 1071 - 0.743 1.251 1.889
ENSG00000187109 E043 3.3492996 6.829997e-03 3.121733e-03 0.1005440752 12 76057744 76057776 33 - 0.398 0.846 2.001
ENSG00000187109 E044 2.8289602 1.155424e-02 4.496086e-05 0.0082685076 12 76057777 76057885 109 - 0.177 0.845 3.579
ENSG00000187109 E045 1.3667818 4.888320e-02 2.321347e-01   12 76059596 76059776 181 - 0.245 0.477 1.398
ENSG00000187109 E046 5.6426561 6.424567e-02 6.455170e-01 0.8945971635 12 76059777 76059797 21 - 0.776 0.871 0.372
ENSG00000187109 E047 1016.9473935 6.051173e-05 2.535075e-01 0.6593003895 12 76059798 76059820 23 - 3.018 3.014 -0.012
ENSG00000187109 E048 1259.3708214 5.468668e-05 1.459046e-01 0.5334834488 12 76059821 76059878 58 - 3.111 3.106 -0.017
ENSG00000187109 E049 1807.8226643 7.238908e-05 2.345874e-03 0.0864426102 12 76060138 76060279 142 - 3.271 3.254 -0.057
ENSG00000187109 E050 5.0673728 5.486156e-03 1.984987e-06 0.0009674419 12 76061010 76061087 78 - 0.398 1.057 2.792
ENSG00000187109 E051 1308.2985579 7.123703e-05 2.126022e-05 0.0051058119 12 76067371 76067473 103 - 3.139 3.105 -0.114
ENSG00000187109 E052 14.5900919 5.942939e-02 2.926129e-05 0.0062485288 12 76067474 76067570 97 - 0.786 1.453 2.422
ENSG00000187109 E053 14.5661963 1.935336e-01 5.063150e-03 0.1276254179 12 76068578 76068908 331 - 0.791 1.452 2.396
ENSG00000187109 E054 1073.4434674 1.673304e-04 1.041593e-05 0.0031554181 12 76068909 76068994 86 - 3.055 3.012 -0.143
ENSG00000187109 E055 7.3461995 3.424932e-03 3.024308e-06 0.0012883165 12 76073805 76074202 398 - 0.603 1.165 2.178
ENSG00000187109 E056 740.5847848 9.916694e-04 4.252158e-03 0.1168525498 12 76074203 76074239 37 - 2.888 2.848 -0.134
ENSG00000187109 E057 8.6092104 6.400060e-03 4.566267e-02 0.3319026105 12 76083833 76084094 262 - 0.862 1.101 0.888
ENSG00000187109 E058 692.2985574 2.099989e-03 1.496041e-02 0.2083430506 12 76084567 76084676 110 - 2.859 2.813 -0.152
ENSG00000187109 E059 15.8291942 1.735259e-03 4.563440e-01 0.8068318187 12 76084677 76084735 59 - 1.211 1.279 0.242
ENSG00000187109 E060 0.1544607 3.253646e-02 3.327524e-01   12 76084928 76084983 56 - 0.000 0.146 10.000