ENSG00000186815

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000335509 ENSG00000186815 HEK293_DMSO_6hA HEK293_OSMI2_6hA TPCN1 protein_coding protein_coding 12.75925 16.25468 18.68541 1.32161 1.412833 0.2009417 3.2924176 2.2259206 5.373266 0.61450551 1.5833811 1.2676127 0.26521667 0.1356333 0.30143333 0.165800000 0.45763021 0.006383489 FALSE TRUE
ENST00000541517 ENSG00000186815 HEK293_DMSO_6hA HEK293_OSMI2_6hA TPCN1 protein_coding protein_coding 12.75925 16.25468 18.68541 1.32161 1.412833 0.2009417 3.0657191 5.5096816 3.343094 0.19251401 0.5506357 -0.7190923 0.24658333 0.3441000 0.17730000 -0.166800000 0.01278675 0.006383489 FALSE TRUE
ENST00000546787 ENSG00000186815 HEK293_DMSO_6hA HEK293_OSMI2_6hA TPCN1 protein_coding processed_transcript 12.75925 16.25468 18.68541 1.32161 1.412833 0.2009417 1.2949621 1.2604864 1.495611 0.74994861 0.5289747 0.2449682 0.09204583 0.0730000 0.08256667 0.009566667 0.86916757 0.006383489 FALSE TRUE
ENST00000550543 ENSG00000186815 HEK293_DMSO_6hA HEK293_OSMI2_6hA TPCN1 protein_coding retained_intron 12.75925 16.25468 18.68541 1.32161 1.412833 0.2009417 0.9108783 1.7726671 1.089944 0.09741510 0.7245118 -0.6966067 0.07384583 0.1100667 0.05470000 -0.055366667 0.39571565 0.006383489   FALSE
ENST00000550785 ENSG00000186815 HEK293_DMSO_6hA HEK293_OSMI2_6hA TPCN1 protein_coding protein_coding 12.75925 16.25468 18.68541 1.32161 1.412833 0.2009417 0.9712412 0.9711286 2.614154 0.19538973 0.6343412 1.4193381 0.06970417 0.0595000 0.13673333 0.077233333 0.16112058 0.006383489 FALSE TRUE
ENST00000551127 ENSG00000186815 HEK293_DMSO_6hA HEK293_OSMI2_6hA TPCN1 protein_coding retained_intron 12.75925 16.25468 18.68541 1.32161 1.412833 0.2009417 1.0233433 2.2256452 1.399500 0.04241364 0.5735853 -0.6655079 0.07865000 0.1386333 0.07176667 -0.066866667 0.33767612 0.006383489 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000186815 E001 0.0000000       12 113221050 113221073 24 +      
ENSG00000186815 E002 0.0000000       12 113221074 113221079 6 +      
ENSG00000186815 E003 0.0000000       12 113221080 113221231 152 +      
ENSG00000186815 E004 0.0000000       12 113221232 113221236 5 +      
ENSG00000186815 E005 0.1717682 0.0322326859 4.402240e-01   12 113221237 113221378 142 + 0.000 0.128 16.843
ENSG00000186815 E006 0.0000000       12 113221429 113221437 9 +      
ENSG00000186815 E007 0.1767706 0.0325195354 5.407192e-01   12 113221438 113221445 8 + 0.111 0.000 -16.564
ENSG00000186815 E008 0.4660578 0.0226054325 1.054712e-01   12 113221446 113221459 14 + 0.273 0.000 -18.147
ENSG00000186815 E009 0.6378259 0.0195408844 3.742074e-01   12 113221460 113221463 4 + 0.273 0.128 -1.350
ENSG00000186815 E010 4.1772826 0.0201046558 6.570052e-02 0.386158775 12 113221464 113221485 22 + 0.801 0.533 -1.140
ENSG00000186815 E011 17.6847090 0.0016475217 4.381697e-05 0.008185869 12 113221486 113221583 98 + 1.392 1.067 -1.150
ENSG00000186815 E012 20.1008791 0.0081557108 3.980343e-03 0.112942527 12 113221584 113221626 43 + 1.417 1.190 -0.797
ENSG00000186815 E013 6.2794586 0.0040742755 3.747302e-03 0.109691169 12 113225244 113225245 2 + 1.002 0.647 -1.396
ENSG00000186815 E014 16.8954974 0.0032365280 2.432618e-01 0.648365983 12 113225246 113225336 91 + 1.282 1.199 -0.295
ENSG00000186815 E015 99.0721667 0.0003081687 6.487497e-01 0.895943523 12 113226728 113226964 237 + 1.995 1.997 0.008
ENSG00000186815 E016 2.9987553 0.0070972254 2.410756e-01 0.646163294 12 113244261 113244361 101 + 0.484 0.680 0.887
ENSG00000186815 E017 2.6004678 0.0079546082 4.714567e-01 0.814536360 12 113244368 113244502 135 + 0.484 0.612 0.599
ENSG00000186815 E018 3.6822509 0.1339064572 5.048584e-01 0.832085967 12 113244503 113244743 241 + 0.595 0.737 0.606
ENSG00000186815 E019 4.4120359 0.0051733381 9.083618e-01 0.978137714 12 113245912 113246063 152 + 0.707 0.738 0.129
ENSG00000186815 E020 0.5203070 0.1027440693 5.330941e-01   12 113260302 113260367 66 + 0.112 0.228 1.228
ENSG00000186815 E021 83.8737659 0.0054570206 3.660381e-01 0.750875334 12 113260368 113260492 125 + 1.944 1.913 -0.101
ENSG00000186815 E022 91.4519434 0.0039349493 4.288064e-01 0.791245553 12 113266180 113266356 177 + 1.975 1.955 -0.067
ENSG00000186815 E023 64.2148432 0.0079930620 3.422471e-01 0.733720160 12 113267843 113267956 114 + 1.827 1.795 -0.108
ENSG00000186815 E024 67.1575364 0.0118463865 1.446855e-01 0.531742227 12 113268742 113268872 131 + 1.860 1.794 -0.222
ENSG00000186815 E025 59.0801991 0.0046309659 8.197840e-02 0.421842431 12 113269757 113269845 89 + 1.804 1.728 -0.256
ENSG00000186815 E026 53.9456767 0.0014071125 2.496083e-01 0.655214398 12 113272658 113272692 35 + 1.747 1.707 -0.136
ENSG00000186815 E027 68.7073662 0.0036692436 1.710833e-01 0.568443672 12 113273232 113273290 59 + 1.860 1.804 -0.187
ENSG00000186815 E028 96.3376396 0.0023407182 4.426220e-01 0.799060088 12 113273569 113273668 100 + 1.987 1.970 -0.057
ENSG00000186815 E029 0.0000000       12 113276918 113276918 1 +      
ENSG00000186815 E030 88.9382449 0.0003317432 6.116030e-02 0.374572654 12 113276919 113277002 84 + 1.970 1.918 -0.174
ENSG00000186815 E031 61.2499242 0.0004447883 8.460569e-01 0.961847151 12 113277003 113277035 33 + 1.774 1.801 0.091
ENSG00000186815 E032 45.7192611 0.0006852188 2.416915e-01 0.646795641 12 113277240 113277252 13 + 1.679 1.637 -0.145
ENSG00000186815 E033 90.1000034 0.0009200434 2.795241e-01 0.682913421 12 113277253 113277364 112 + 1.964 1.940 -0.083
ENSG00000186815 E034 70.8544723 0.0004313718 1.864850e-01 0.587294024 12 113278189 113278237 49 + 1.868 1.831 -0.125
ENSG00000186815 E035 74.0980070 0.0004688575 6.842068e-01 0.909723301 12 113278772 113278835 64 + 1.854 1.889 0.117
ENSG00000186815 E036 64.1107656 0.0029497243 6.228154e-01 0.885311797 12 113280151 113280195 45 + 1.788 1.831 0.144
ENSG00000186815 E037 2.8896648 0.0075843729 5.429628e-02 0.356685143 12 113280196 113280314 119 + 0.391 0.710 1.498
ENSG00000186815 E038 76.1818974 0.0046053043 2.829566e-01 0.685804543 12 113284581 113284624 44 + 1.849 1.919 0.234
ENSG00000186815 E039 60.6670887 0.0009626856 6.611180e-01 0.900895640 12 113284625 113284637 13 + 1.766 1.803 0.127
ENSG00000186815 E040 1.6416247 0.0115685438 1.488341e-01 0.537633428 12 113284716 113284717 2 + 0.273 0.532 1.458
ENSG00000186815 E041 82.7181732 0.0008678505 7.494296e-01 0.932467607 12 113284718 113284771 54 + 1.914 1.918 0.014
ENSG00000186815 E042 88.4528413 0.0003881061 3.423085e-01 0.733747646 12 113285889 113285961 73 + 1.954 1.936 -0.058
ENSG00000186815 E043 93.8211636 0.0003692467 4.321647e-02 0.324160687 12 113286987 113287094 108 + 1.995 1.940 -0.187
ENSG00000186815 E044 18.4426289 0.1924366363 8.765503e-02 0.433550056 12 113287095 113287404 310 + 1.162 1.383 0.776
ENSG00000186815 E045 79.4697658 0.0004182125 1.128728e-01 0.480700058 12 113288163 113288234 72 + 1.920 1.875 -0.151
ENSG00000186815 E046 27.9926352 0.1144497621 5.634103e-02 0.361924959 12 113288235 113288494 260 + 1.322 1.568 0.846
ENSG00000186815 E047 13.8427341 0.0847816305 7.865755e-01 0.944121971 12 113288495 113288526 32 + 1.158 1.172 0.053
ENSG00000186815 E048 30.1794681 0.0556979373 4.634760e-01 0.810405720 12 113288527 113288757 231 + 1.448 1.524 0.263
ENSG00000186815 E049 92.1560623 0.0014585664 8.447858e-02 0.426769467 12 113288758 113288847 90 + 1.986 1.933 -0.179
ENSG00000186815 E050 0.8095941 0.0365060426 7.581638e-01   12 113290049 113290127 79 + 0.274 0.227 -0.351
ENSG00000186815 E051 116.9598947 0.0003547181 9.235553e-01 0.981778891 12 113290128 113290243 116 + 2.059 2.073 0.049
ENSG00000186815 E052 97.2678845 0.0003517422 2.906143e-01 0.691966362 12 113290952 113290998 47 + 1.958 2.014 0.187
ENSG00000186815 E053 128.3361210 0.0002752284 3.373775e-01 0.730024105 12 113291609 113291677 69 + 2.079 2.128 0.162
ENSG00000186815 E054 3.7626553 0.0061696562 8.441278e-02 0.426592194 12 113291678 113291873 196 + 0.523 0.790 1.142
ENSG00000186815 E055 148.5055892 0.0002325997 4.595522e-01 0.808368662 12 113291874 113291958 85 + 2.150 2.190 0.133
ENSG00000186815 E056 62.3815207 0.0965698576 2.774785e-02 0.270140921 12 113291959 113292933 975 + 1.657 1.912 0.863
ENSG00000186815 E057 123.4183740 0.0024969500 9.948153e-01 0.998627841 12 113292934 113293018 85 + 2.085 2.103 0.061
ENSG00000186815 E058 79.9030667 0.0003886003 6.729630e-01 0.905175250 12 113293019 113293073 55 + 1.883 1.918 0.119
ENSG00000186815 E059 99.0611033 0.0004041599 4.690389e-01 0.813531292 12 113293269 113293349 81 + 1.969 2.014 0.150
ENSG00000186815 E060 2.3190071 0.0090919606 7.614078e-01 0.936339682 12 113294106 113294228 123 + 0.524 0.486 -0.182
ENSG00000186815 E061 1140.4461264 0.0085461335 4.254884e-01 0.789504725 12 113295960 113298585 2626 + 3.031 3.083 0.174