ENSG00000185504

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000327787 ENSG00000185504 HEK293_DMSO_6hA HEK293_OSMI2_6hA FAAP100 protein_coding protein_coding 28.14261 22.90473 44.04619 3.351862 7.692837 0.9430696 10.830925 7.455028 18.052069 1.2579881 5.1729866 1.27474364 0.34919167 0.3229333 0.3902667 0.06733333 0.72040567 0.01896307 FALSE TRUE
ENST00000425898 ENSG00000185504 HEK293_DMSO_6hA HEK293_OSMI2_6hA FAAP100 protein_coding protein_coding 28.14261 22.90473 44.04619 3.351862 7.692837 0.9430696 5.563054 6.799684 8.613701 0.6063706 0.7140994 0.34071944 0.20822083 0.3035000 0.2049000 -0.09860000 0.25179126 0.01896307 FALSE TRUE
ENST00000443656 ENSG00000185504 HEK293_DMSO_6hA HEK293_OSMI2_6hA FAAP100 protein_coding nonsense_mediated_decay 28.14261 22.90473 44.04619 3.351862 7.692837 0.9430696 7.936585 4.472760 13.335888 0.5449690 2.4971166 1.57393596 0.28253333 0.1983667 0.3010000 0.10263333 0.01896307 0.01896307 FALSE TRUE
ENST00000541246 ENSG00000185504 HEK293_DMSO_6hA HEK293_OSMI2_6hA FAAP100 protein_coding protein_coding 28.14261 22.90473 44.04619 3.351862 7.692837 0.9430696 1.531168 2.051532 2.107915 0.6923047 0.7769681 0.03892822 0.07389583 0.0834000 0.0590000 -0.02440000 0.74051369 0.01896307 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000185504 E001 4.4435930 0.0052171269 0.023393197 0.2519311 17 81539754 81539884 131 - 0.581 0.896 1.290
ENSG00000185504 E002 2.0835869 0.0091422063 0.062809652 0.3792605 17 81539885 81539885 1 - 0.336 0.647 1.553
ENSG00000185504 E003 2.4443698 0.0085040878 0.060922891 0.3739756 17 81539886 81539890 5 - 0.381 0.687 1.459
ENSG00000185504 E004 401.5538845 0.0003921032 0.665409725 0.9025023 17 81539891 81540272 382 - 2.597 2.596 -0.003
ENSG00000185504 E005 232.9438299 0.0003025846 0.982670510 0.9957656 17 81540273 81540312 40 - 2.360 2.365 0.019
ENSG00000185504 E006 905.1747219 0.0006243803 0.769664774 0.9394030 17 81540313 81540950 638 - 2.944 2.951 0.023
ENSG00000185504 E007 272.3807346 0.0022982945 0.502354759 0.8309099 17 81541309 81541395 87 - 2.416 2.443 0.088
ENSG00000185504 E008 297.8896631 0.0049201011 0.502173808 0.8307681 17 81544004 81544120 117 - 2.451 2.483 0.108
ENSG00000185504 E009 282.5894102 0.0054690164 0.769313141 0.9392938 17 81545746 81545882 137 - 2.435 2.451 0.054
ENSG00000185504 E010 4.3884273 0.0056748624 0.002586346 0.0910905 17 81546401 81546540 140 - 0.523 0.941 1.724
ENSG00000185504 E011 460.6061442 0.0001601728 0.037986454 0.3069679 17 81546909 81547322 414 - 2.667 2.638 -0.098
ENSG00000185504 E012 411.1988803 0.0002839828 0.853388621 0.9636400 17 81547323 81547678 356 - 2.603 2.608 0.015
ENSG00000185504 E013 181.6019475 0.0298966102 0.009901544 0.1728340 17 81547679 81548498 820 - 2.139 2.382 0.812
ENSG00000185504 E014 129.0121030 0.0020066482 0.370945156 0.7539848 17 81549206 81549253 48 - 2.107 2.086 -0.072
ENSG00000185504 E015 216.8427262 0.0001708776 0.051794931 0.3492059 17 81549254 81549362 109 - 2.343 2.301 -0.141
ENSG00000185504 E016 165.6839200 0.0002477030 0.840979418 0.9606507 17 81550248 81550291 44 - 2.212 2.213 0.001
ENSG00000185504 E017 549.2555682 0.0005011466 0.781975440 0.9428004 17 81550292 81550796 505 - 2.726 2.733 0.023
ENSG00000185504 E018 373.8764290 0.0004091539 0.568072086 0.8614590 17 81550797 81551203 407 - 2.563 2.561 -0.006
ENSG00000185504 E019 98.1821444 0.0006054171 0.145684890 0.5332820 17 81551732 81551927 196 - 2.001 1.953 -0.159
ENSG00000185504 E020 135.2738894 0.0003391179 0.180772023 0.5803315 17 81551928 81552052 125 - 2.141 2.104 -0.124
ENSG00000185504 E021 74.9937632 0.0061205074 0.831597671 0.9573949 17 81552166 81552193 28 - 1.873 1.873 0.002
ENSG00000185504 E022 95.2379086 0.0005545087 0.778820136 0.9420143 17 81552194 81552401 208 - 1.969 1.985 0.055
ENSG00000185504 E023 5.5415940 0.0180173804 0.116672608 0.4875498 17 81553074 81553127 54 - 0.867 0.647 -0.888
ENSG00000185504 E024 0.2842848 0.0262884475 0.664133718   17 81553445 81553961 517 - 0.091 0.155 0.876