ENSG00000184708

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000330125 ENSG00000184708 HEK293_DMSO_6hA HEK293_OSMI2_6hA EIF4ENIF1 protein_coding protein_coding 21.14001 18.45979 22.01143 1.358267 2.793843 0.2537405 14.506840 12.9460116 15.7381189 0.44101068 1.8643674 0.2815578 0.68820833 0.70670000 0.71866667 0.01196667 0.93850428 0.02815776 FALSE TRUE
ENST00000397523 ENSG00000184708 HEK293_DMSO_6hA HEK293_OSMI2_6hA EIF4ENIF1 protein_coding protein_coding 21.14001 18.45979 22.01143 1.358267 2.793843 0.2537405 1.536621 1.2492025 1.1566785 0.69369862 0.5783704 -0.1101032 0.07132083 0.06266667 0.05446667 -0.00820000 0.99425111 0.02815776 FALSE TRUE
MSTRG.21972.11 ENSG00000184708 HEK293_DMSO_6hA HEK293_OSMI2_6hA EIF4ENIF1 protein_coding   21.14001 18.45979 22.01143 1.358267 2.793843 0.2537405 1.710252 0.1981445 3.0820870 0.19814445 0.4359236 3.8929239 0.07929583 0.00960000 0.13980000 0.13020000 0.02815776 0.02815776 FALSE TRUE
MSTRG.21972.8 ENSG00000184708 HEK293_DMSO_6hA HEK293_OSMI2_6hA EIF4ENIF1 protein_coding   21.14001 18.45979 22.01143 1.358267 2.793843 0.2537405 1.127269 2.1179477 0.5021922 0.08360896 0.5021922 -2.0547055 0.05442917 0.11616667 0.01853333 -0.09763333 0.16191701 0.02815776 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000184708 E001 3.1983491 0.2026084699 0.385935357 0.76446421 22 31435167 31436310 1144 - 0.499 0.720 0.983
ENSG00000184708 E002 1.8486364 0.0101111536 0.002445545 0.08857899 22 31436311 31436976 666 - 0.114 0.638 3.474
ENSG00000184708 E003 0.4387454 0.0237910373 0.508824104   22 31436977 31437075 99 - 0.114 0.222 1.156
ENSG00000184708 E004 1.2248070 0.0503748017 0.889727253   22 31437076 31437342 267 - 0.341 0.370 0.172
ENSG00000184708 E005 0.0000000       22 31437343 31437452 110 -      
ENSG00000184708 E006 0.0000000       22 31437453 31437512 60 -      
ENSG00000184708 E007 0.2669773 0.0274424043 0.938903234   22 31437513 31437685 173 - 0.114 0.125 0.156
ENSG00000184708 E008 1.6399265 0.0115484999 0.157920543 0.55111874 22 31437686 31437818 133 - 0.279 0.524 1.375
ENSG00000184708 E009 0.1767706 0.0343283566 0.530717908   22 31439209 31439212 4 - 0.114 0.000 -9.024
ENSG00000184708 E010 0.3563434 0.0276340065 0.944092131   22 31439213 31439303 91 - 0.114 0.125 0.151
ENSG00000184708 E011 0.4688600 0.0217681645 0.627144236   22 31439304 31439358 55 - 0.204 0.125 -0.845
ENSG00000184708 E012 0.4046060 0.0900612700 0.652793431   22 31439359 31439364 6 - 0.202 0.125 -0.822
ENSG00000184708 E013 0.7670261 0.0182486838 0.208566697   22 31439365 31439366 2 - 0.343 0.125 -1.845
ENSG00000184708 E014 2.0231703 0.0090045940 0.522562104 0.84134007 22 31439367 31439372 6 - 0.532 0.427 -0.523
ENSG00000184708 E015 246.9176251 0.0034812899 0.234487738 0.63947689 22 31439373 31439809 437 - 2.368 2.411 0.142
ENSG00000184708 E016 228.8100034 0.0013616326 0.624938162 0.88597223 22 31439810 31440121 312 - 2.362 2.350 -0.039
ENSG00000184708 E017 160.7460700 0.0027180179 0.519578849 0.83996245 22 31440704 31440868 165 - 2.216 2.195 -0.068
ENSG00000184708 E018 82.3937503 0.0024491563 0.191696893 0.59379397 22 31441774 31441802 29 - 1.942 1.887 -0.186
ENSG00000184708 E019 238.9562752 0.0001720571 0.227640411 0.63271885 22 31441803 31442034 232 - 2.387 2.362 -0.086
ENSG00000184708 E020 142.5512927 0.0003182633 0.579113707 0.86658869 22 31442035 31442118 84 - 2.158 2.143 -0.050
ENSG00000184708 E021 150.2242574 0.0002123798 0.706489893 0.91751165 22 31442962 31443094 133 - 2.178 2.169 -0.030
ENSG00000184708 E022 5.0934796 0.0355666153 0.032826598 0.29034763 22 31443095 31443419 325 - 0.574 0.905 1.356
ENSG00000184708 E023 2.5344864 0.0087763531 0.001777109 0.07485228 22 31444438 31444605 168 - 0.204 0.728 2.856
ENSG00000184708 E024 82.7108857 0.0004223844 0.555438382 0.85622195 22 31444606 31444631 26 - 1.929 1.908 -0.070
ENSG00000184708 E025 103.4154123 0.0004486617 0.867138908 0.96737331 22 31444632 31444690 59 - 2.015 2.011 -0.012
ENSG00000184708 E026 0.7922866 0.0188905182 0.740922404   22 31446938 31447008 71 - 0.279 0.222 -0.433
ENSG00000184708 E027 149.6232057 0.0025122810 0.301494715 0.70108035 22 31447426 31447565 140 - 2.193 2.157 -0.120
ENSG00000184708 E028 24.6652993 0.0011124625 0.462860261 0.81010686 22 31447566 31447568 3 - 1.424 1.375 -0.170
ENSG00000184708 E029 141.0682538 0.0003197430 0.867240611 0.96740142 22 31448153 31448232 80 - 2.150 2.146 -0.011
ENSG00000184708 E030 117.1239953 0.0015070538 0.255602884 0.66136729 22 31449348 31449408 61 - 2.045 2.088 0.144
ENSG00000184708 E031 148.1062837 0.0024713621 0.617145037 0.88280009 22 31449409 31449531 123 - 2.181 2.162 -0.064
ENSG00000184708 E032 152.3902948 0.0007784554 0.410651715 0.78081288 22 31450289 31450360 72 - 2.194 2.170 -0.082
ENSG00000184708 E033 4.1442559 0.3116491381 0.440329196 0.79798769 22 31450361 31451260 900 - 0.628 0.772 0.598
ENSG00000184708 E034 151.4794784 0.0032156073 0.909422091 0.97832956 22 31454144 31454179 36 - 2.179 2.181 0.007
ENSG00000184708 E035 314.4204416 0.0011221486 0.515615903 0.83801799 22 31454180 31454376 197 - 2.487 2.503 0.053
ENSG00000184708 E036 274.3772726 0.0002440534 0.571047014 0.86269083 22 31455136 31455315 180 - 2.428 2.442 0.047
ENSG00000184708 E037 218.9737484 0.0028968217 0.495911940 0.82731816 22 31455852 31455987 136 - 2.328 2.352 0.081
ENSG00000184708 E038 224.6264523 0.0036228141 0.994897938 0.99862784 22 31458475 31458650 176 - 2.350 2.351 0.003
ENSG00000184708 E039 266.7039136 0.0001906035 0.772267832 0.94004953 22 31462932 31463133 202 - 2.424 2.420 -0.015
ENSG00000184708 E040 126.9223790 0.0016695568 0.816068889 0.95329117 22 31463681 31463699 19 - 2.096 2.105 0.031
ENSG00000184708 E041 301.3795797 0.0001662575 0.861507977 0.96621074 22 31463700 31463967 268 - 2.474 2.479 0.017
ENSG00000184708 E042 162.8036087 0.0016271230 0.727713351 0.92495111 22 31468175 31468281 107 - 2.207 2.218 0.036
ENSG00000184708 E043 98.7371748 0.0003586734 0.919982980 0.98081800 22 31468282 31468302 21 - 1.996 1.994 -0.007
ENSG00000184708 E044 122.5239611 0.0003077179 0.443436780 0.79961549 22 31471844 31471917 74 - 2.073 2.099 0.088
ENSG00000184708 E045 102.3764111 0.0003601943 0.984339851 0.99621886 22 31488623 31488745 123 - 2.009 2.011 0.008
ENSG00000184708 E046 1.4843008 0.0132937700 0.855634074   22 31489148 31489233 86 - 0.399 0.369 -0.173
ENSG00000184708 E047 2.5276560 0.0097098843 0.662267144 0.90135806 22 31489234 31489343 110 - 0.493 0.565 0.341
ENSG00000184708 E048 0.9813013 0.0154915549 0.487375800   22 31489391 31489587 197 - 0.343 0.222 -0.850
ENSG00000184708 E049 36.2611346 0.0087700326 0.694522689 0.91335383 22 31489694 31489904 211 - 1.583 1.553 -0.101
ENSG00000184708 E050 1.4056926 0.1301075893 0.402496072   22 31489905 31491539 1635 - 0.483 0.300 -1.034
ENSG00000184708 E051 1.1636764 0.0151932831 0.618057512   22 31495953 31496108 156 - 0.279 0.369 0.568