ENSG00000184508

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000330334 ENSG00000184508 HEK293_DMSO_6hA HEK293_OSMI2_6hA HDDC3 protein_coding protein_coding 48.67834 38.84447 62.305 3.135127 12.46674 0.681499 13.397431 11.165311 15.965724 0.9814130 2.5746359 0.51556632 0.28265000 0.28773333 0.26173333 -0.02600000 0.74305443 0.04264275 FALSE TRUE
ENST00000394272 ENSG00000184508 HEK293_DMSO_6hA HEK293_OSMI2_6hA HDDC3 protein_coding protein_coding 48.67834 38.84447 62.305 3.135127 12.46674 0.681499 4.519101 3.728550 5.228452 0.3796079 0.8639980 0.48666158 0.09217500 0.09566667 0.08550000 -0.01016667 0.74957775 0.04264275 FALSE TRUE
ENST00000494993 ENSG00000184508 HEK293_DMSO_6hA HEK293_OSMI2_6hA HDDC3 protein_coding retained_intron 48.67834 38.84447 62.305 3.135127 12.46674 0.681499 11.337557 10.151126 13.287996 0.6943923 2.7887732 0.38814858 0.24576667 0.26280000 0.21216667 -0.05063333 0.29653511 0.04264275   FALSE
ENST00000559834 ENSG00000184508 HEK293_DMSO_6hA HEK293_OSMI2_6hA HDDC3 protein_coding retained_intron 48.67834 38.84447 62.305 3.135127 12.46674 0.681499 2.603572 2.604811 2.518792 0.2033296 0.1283969 -0.04825841 0.06184583 0.06716667 0.04540000 -0.02176667 0.53385524 0.04264275   FALSE
ENST00000559898 ENSG00000184508 HEK293_DMSO_6hA HEK293_OSMI2_6hA HDDC3 protein_coding protein_coding 48.67834 38.84447 62.305 3.135127 12.46674 0.681499 3.220995 3.850546 4.034286 0.2730290 0.2762791 0.06708009 0.07859167 0.10123333 0.06996667 -0.03126667 0.54113305 0.04264275 FALSE TRUE
ENST00000646620 ENSG00000184508 HEK293_DMSO_6hA HEK293_OSMI2_6hA HDDC3 protein_coding protein_coding 48.67834 38.84447 62.305 3.135127 12.46674 0.681499 11.919690 5.898147 18.688095 1.0165337 5.5285545 1.66211359 0.20762917 0.14950000 0.28410000 0.13460000 0.04264275 0.04264275 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000184508 E001 34.365127 0.0007937458 0.728446765 0.9252365 15 90929968 90930311 344 - 1.536 1.559 0.078
ENSG00000184508 E002 62.346557 0.0053400491 0.221020189 0.6256536 15 90930312 90930917 606 - 1.758 1.838 0.271
ENSG00000184508 E003 15.651953 0.0017118232 0.075937393 0.4089421 15 90930918 90930924 7 - 1.142 1.295 0.543
ENSG00000184508 E004 287.829339 0.0009316985 0.930970267 0.9834769 15 90930925 90931098 174 - 2.456 2.462 0.020
ENSG00000184508 E005 280.960952 0.0015689834 0.821950684 0.9550029 15 90931099 90931150 52 - 2.449 2.447 -0.007
ENSG00000184508 E006 660.752432 0.0003305116 0.653531549 0.8979326 15 90931151 90931336 186 - 2.820 2.817 -0.008
ENSG00000184508 E007 432.034719 0.0002871849 0.406503921 0.7778717 15 90931337 90931405 69 - 2.640 2.629 -0.038
ENSG00000184508 E008 57.797061 0.0178423066 0.014399432 0.2049399 15 90931406 90931556 151 - 1.664 1.866 0.684
ENSG00000184508 E009 28.778309 0.0074513319 0.006191199 0.1394695 15 90931557 90931703 147 - 1.367 1.577 0.723
ENSG00000184508 E010 754.465402 0.0000967980 0.110839275 0.4771639 15 90931704 90931944 241 - 2.883 2.867 -0.053
ENSG00000184508 E011 29.915609 0.0188233161 0.020761617 0.2393905 15 90931945 90932054 110 - 1.370 1.596 0.778
ENSG00000184508 E012 373.851182 0.0014409991 0.468169099 0.8129842 15 90932055 90932110 56 - 2.573 2.566 -0.022
ENSG00000184508 E013 95.898722 0.0080358731 0.004316363 0.1179520 15 90932111 90932385 275 - 1.898 2.070 0.578
ENSG00000184508 E014 23.705050 0.0024369163 0.688299415 0.9113001 15 90932386 90932428 43 - 1.381 1.413 0.111
ENSG00000184508 E015 294.981642 0.0009090735 0.002067538 0.0810586 15 90932429 90932601 173 - 2.498 2.429 -0.228
ENSG00000184508 E016 6.980932 0.0034304088 0.917342912 0.9802613 15 90932602 90932755 154 - 0.908 0.897 -0.041
ENSG00000184508 E017 4.680117 0.0070555570 0.415695729 0.7838498 15 90932756 90932806 51 - 0.796 0.683 -0.458
ENSG00000184508 E018 23.144829 0.1603257486 0.140776142 0.5263912 15 90932807 90934984 2178 - 1.240 1.507 0.930
ENSG00000184508 E019 9.267047 0.0415807652 0.754116967 0.9338004 15 90934985 90935196 212 - 1.017 0.994 -0.087