ENSG00000184007

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000457805 ENSG00000184007 HEK293_DMSO_6hA HEK293_OSMI2_6hA PTP4A2 protein_coding protein_coding 157.2186 74.22953 78.83451 19.41217 18.22844 0.08682261 28.428967 9.803384 3.184006 3.629218 1.861439 -1.6193836 0.15851250 0.12593333 0.03273333 -0.09320000 5.924820e-01 2.089506e-06 FALSE TRUE
ENST00000468531 ENSG00000184007 HEK293_DMSO_6hA HEK293_OSMI2_6hA PTP4A2 protein_coding protein_coding 157.2186 74.22953 78.83451 19.41217 18.22844 0.08682261 2.865961 0.000000 4.918026 0.000000 2.865997 8.9448659 0.01726667 0.00000000 0.05060000 0.05060000 3.559576e-01 2.089506e-06   FALSE
ENST00000528840 ENSG00000184007 HEK293_DMSO_6hA HEK293_OSMI2_6hA PTP4A2 protein_coding processed_transcript 157.2186 74.22953 78.83451 19.41217 18.22844 0.08682261 10.633684 5.018966 0.000000 2.557649 0.000000 -8.9741181 0.05915000 0.07176667 0.00000000 -0.07176667 3.983205e-01 2.089506e-06   FALSE
ENST00000529477 ENSG00000184007 HEK293_DMSO_6hA HEK293_OSMI2_6hA PTP4A2 protein_coding processed_transcript 157.2186 74.22953 78.83451 19.41217 18.22844 0.08682261 15.283671 7.911730 0.000000 4.414684 0.000000 -9.6296716 0.07765833 0.09013333 0.00000000 -0.09013333 3.750417e-01 2.089506e-06   FALSE
ENST00000602683 ENSG00000184007 HEK293_DMSO_6hA HEK293_OSMI2_6hA PTP4A2 protein_coding protein_coding 157.2186 74.22953 78.83451 19.41217 18.22844 0.08682261 19.288976 5.458789 12.046228 1.393273 2.322116 1.1404852 0.12518750 0.07376667 0.15793333 0.08416667 2.089506e-06 2.089506e-06 FALSE TRUE
ENST00000602725 ENSG00000184007 HEK293_DMSO_6hA HEK293_OSMI2_6hA PTP4A2 protein_coding protein_coding 157.2186 74.22953 78.83451 19.41217 18.22844 0.08682261 31.735706 27.234121 18.474545 6.968569 5.033318 -0.5596254 0.22407917 0.36830000 0.23163333 -0.13666667 1.546068e-01 2.089506e-06 FALSE TRUE
ENST00000647444 ENSG00000184007 HEK293_DMSO_6hA HEK293_OSMI2_6hA PTP4A2 protein_coding protein_coding 157.2186 74.22953 78.83451 19.41217 18.22844 0.08682261 29.954887 7.797963 10.697072 1.748265 2.053292 0.4555459 0.18012917 0.10950000 0.13953333 0.03003333 5.855622e-01 2.089506e-06 FALSE TRUE
MSTRG.747.5 ENSG00000184007 HEK293_DMSO_6hA HEK293_OSMI2_6hA PTP4A2 protein_coding   157.2186 74.22953 78.83451 19.41217 18.22844 0.08682261 9.615138 8.503111 23.012748 1.241147 3.637150 1.4353018 0.09719583 0.12466667 0.31073333 0.18606667 3.223585e-03 2.089506e-06 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000184007 E001 1649.8220422 0.0061611246 3.343041e-07 0.0002552867 1 31906421 31908262 1842 - 3.102 3.306 0.678
ENSG00000184007 E002 305.2265057 0.0001676142 1.369856e-07 0.0001289758 1 31908263 31908533 271 - 2.414 2.552 0.459
ENSG00000184007 E003 135.7837017 0.0066585011 1.590338e-02 0.2143348030 1 31908534 31908585 52 - 2.056 2.202 0.488
ENSG00000184007 E004 163.8629557 0.0066492143 2.317804e-02 0.2508154079 1 31908586 31908652 67 - 2.141 2.280 0.465
ENSG00000184007 E005 99.7178484 0.0005160183 1.731351e-03 0.0738955271 1 31908653 31908657 5 - 1.926 2.069 0.481
ENSG00000184007 E006 276.3091610 0.0006607423 2.255122e-02 0.2479128593 1 31908658 31908707 50 - 2.399 2.483 0.280
ENSG00000184007 E007 555.2775769 0.0000992763 4.190408e-01 0.7856041834 1 31908708 31908838 131 - 2.727 2.769 0.140
ENSG00000184007 E008 689.1131446 0.0001254095 4.906959e-01 0.8248354122 1 31908839 31908960 122 - 2.832 2.853 0.070
ENSG00000184007 E009 429.4815328 0.0001243522 3.682112e-01 0.7522611932 1 31910038 31910068 31 - 2.631 2.645 0.048
ENSG00000184007 E010 441.9827847 0.0001107044 1.656910e-02 0.2180297248 1 31910069 31910112 44 - 2.656 2.645 -0.035
ENSG00000184007 E011 5.7680162 0.0212803783 1.960927e-01 0.5992151541 1 31910113 31911280 1168 - 0.719 0.919 0.787
ENSG00000184007 E012 694.0698648 0.0004095158 5.736523e-03 0.1350767247 1 31911696 31911826 131 - 2.853 2.838 -0.050
ENSG00000184007 E013 1.6504427 0.0120886095 5.148736e-01 0.8375541167 1 31912981 31913023 43 - 0.345 0.475 0.712
ENSG00000184007 E014 1.2439656 0.0507868205 3.555836e-02   1 31913787 31913843 57 - 0.114 0.520 2.937
ENSG00000184007 E015 1.7607199 0.0171613303 3.796089e-01 0.7599286488 1 31915540 31915894 355 - 0.495 0.366 -0.683
ENSG00000184007 E016 353.7943216 0.0006918710 4.065277e-02 0.3164175306 1 31915895 31915987 93 - 2.562 2.546 -0.052
ENSG00000184007 E017 320.0490824 0.0007535862 2.509704e-02 0.2590919372 1 31918970 31918999 30 - 2.522 2.499 -0.077
ENSG00000184007 E018 477.8496221 0.0010677405 4.956103e-04 0.0358582397 1 31919000 31919093 94 - 2.708 2.660 -0.162
ENSG00000184007 E019 300.9050061 0.0009610028 7.777534e-05 0.0117388228 1 31919094 31919129 36 - 2.519 2.450 -0.230
ENSG00000184007 E020 344.3888892 0.0015404644 9.142559e-06 0.0028639021 1 31919130 31919228 99 - 2.585 2.497 -0.293
ENSG00000184007 E021 191.9364883 0.0006838560 7.398059e-06 0.0024766160 1 31919229 31919243 15 - 2.336 2.241 -0.317
ENSG00000184007 E022 171.3325466 0.0007499579 2.348611e-05 0.0054179995 1 31919244 31919246 3 - 2.286 2.192 -0.314
ENSG00000184007 E023 163.0633663 0.0019281058 2.320343e-04 0.0224330088 1 31919247 31919259 13 - 2.265 2.170 -0.318
ENSG00000184007 E024 482.8945301 0.0003340044 6.015838e-03 0.1375812724 1 31919260 31919423 164 - 2.697 2.679 -0.060
ENSG00000184007 E025 479.1472152 0.0002226642 6.053842e-03 0.1381214567 1 31919424 31919562 139 - 2.693 2.677 -0.054
ENSG00000184007 E026 174.8774665 0.0084686427 3.046634e-01 0.7035829713 1 31919563 31919568 6 - 2.257 2.239 -0.058
ENSG00000184007 E027 231.8333003 0.0049027471 8.597866e-02 0.4299296295 1 31919569 31919658 90 - 2.387 2.351 -0.120
ENSG00000184007 E028 1.2073187 0.0724604626 2.747735e-01   1 31924018 31924165 148 - 0.207 0.425 1.439
ENSG00000184007 E029 0.3340335 0.0274424043 2.012164e-01   1 31930039 31930334 296 - 0.000 0.221 13.108
ENSG00000184007 E030 3.9441892 0.0072389510 7.278505e-01 0.9249765547 1 31930933 31931142 210 - 0.694 0.667 -0.114
ENSG00000184007 E031 0.6602624 0.0186694085 3.692599e-02   1 31932672 31932700 29 - 0.000 0.366 14.108
ENSG00000184007 E032 2.3196058 0.1282573546 9.319770e-01 0.9838019876 1 31935589 31935659 71 - 0.504 0.519 0.069
ENSG00000184007 E033 0.1767706 0.0739448135 4.937248e-01   1 31937755 31937777 23 - 0.115 0.000 -12.021
ENSG00000184007 E034 0.1767706 0.0739448135 4.937248e-01   1 31937778 31937841 64 - 0.115 0.000 -12.021
ENSG00000184007 E035 0.3624201 0.3911194051 3.008826e-01   1 31937842 31937986 145 - 0.214 0.000 -13.065
ENSG00000184007 E036 143.7323887 0.0002208621 1.729548e-05 0.0044629940 1 31937987 31938059 73 - 2.209 2.113 -0.323
ENSG00000184007 E037 53.5194268 0.0056692050 4.763208e-02 0.3374959065 1 31938060 31938118 59 - 1.780 1.693 -0.296
ENSG00000184007 E038 48.0872268 0.0088178789 1.615786e-03 0.0711534308 1 31938119 31938262 144 - 1.785 1.592 -0.657
ENSG00000184007 E039 30.2722875 0.0033976075 7.008554e-05 0.0109979210 1 31938263 31938368 106 - 1.611 1.366 -0.842
ENSG00000184007 E040 0.0000000       1 31942529 31942576 48 -      
ENSG00000184007 E041 0.2892872 0.0260983465 2.071968e-01   1 31944593 31944856 264 - 0.206 0.000 -13.015