ENSG00000183814

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000460719 ENSG00000183814 HEK293_DMSO_6hA HEK293_OSMI2_6hA LIN9 protein_coding protein_coding 10.90063 2.170739 2.203149 0.7498209 0.1375072 0.02128353 0.4668326 0.0000000 0.25281106 0.00000000 0.04674937 4.7159541 0.0839250 0.0000000 0.116833333 0.1168333 0.006884645 0.006884645 FALSE TRUE
ENST00000481685 ENSG00000183814 HEK293_DMSO_6hA HEK293_OSMI2_6hA LIN9 protein_coding protein_coding 10.90063 2.170739 2.203149 0.7498209 0.1375072 0.02128353 0.9418780 0.2794436 0.01909113 0.04057623 0.01909113 -3.3146308 0.0707250 0.1455333 0.008166667 -0.1373667 0.021360519 0.006884645 FALSE TRUE
ENST00000681046 ENSG00000183814 HEK293_DMSO_6hA HEK293_OSMI2_6hA LIN9 protein_coding protein_coding 10.90063 2.170739 2.203149 0.7498209 0.1375072 0.02128353 6.2151604 1.5872241 1.37672938 0.56451678 0.21966161 -0.2038805 0.6052792 0.7268667 0.617466667 -0.1094000 0.717659550 0.006884645 FALSE TRUE
MSTRG.3160.8 ENSG00000183814 HEK293_DMSO_6hA HEK293_OSMI2_6hA LIN9 protein_coding   10.90063 2.170739 2.203149 0.7498209 0.1375072 0.02128353 2.3156228 0.0000000 0.22899787 0.00000000 0.13278864 4.5789258 0.1311958 0.0000000 0.104700000 0.1047000 0.310070637 0.006884645 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000183814 E001 0.0000000       1 226231149 226231156 8 -      
ENSG00000183814 E002 46.8855593 0.0034841114 0.245301671 0.6508260 1 226231157 226232257 1101 - 1.653 1.712 0.200
ENSG00000183814 E003 5.6426573 0.0279142042 0.485423411 0.8222612 1 226232258 226232297 40 - 0.867 0.781 -0.338
ENSG00000183814 E004 5.9346349 0.0077997671 0.900548764 0.9763120 1 226232298 226232326 29 - 0.846 0.865 0.073
ENSG00000183814 E005 28.7529092 0.0012643138 0.343520961 0.7346268 1 226232327 226232606 280 - 1.446 1.509 0.216
ENSG00000183814 E006 3.7583423 0.0165736928 0.001897371 0.0775176 1 226232713 226233095 383 - 0.356 0.846 2.245
ENSG00000183814 E007 16.5172715 0.0024582970 0.666058124 0.9027564 1 226233096 226233193 98 - 1.273 1.242 -0.109
ENSG00000183814 E008 25.3252815 0.0012165175 0.379313178 0.7596119 1 226233344 226233523 180 - 1.452 1.399 -0.183
ENSG00000183814 E009 22.1650227 0.0064933720 0.572472785 0.8632780 1 226238971 226239096 126 - 1.341 1.397 0.192
ENSG00000183814 E010 6.0585305 0.0042950265 0.059148903 0.3693803 1 226246201 226246366 166 - 0.710 0.950 0.940
ENSG00000183814 E011 1.0104384 0.0167792873 0.429460711   1 226247984 226247993 10 - 0.214 0.355 0.992
ENSG00000183814 E012 1.8351662 0.0130406429 0.399056997 0.7726955 1 226247994 226248092 99 - 0.357 0.507 0.797
ENSG00000183814 E013 2.9837963 0.0121993613 0.682536135 0.9091221 1 226248093 226248203 111 - 0.550 0.619 0.310
ENSG00000183814 E014 17.4570161 0.0259469573 0.262966038 0.6680138 1 226250839 226250919 81 - 1.182 1.328 0.515
ENSG00000183814 E015 18.4058789 0.0201311580 0.625243301 0.8861027 1 226265533 226265634 102 - 1.254 1.317 0.219
ENSG00000183814 E016 20.4855939 0.0018009022 0.625750874 0.8863213 1 226266213 226266332 120 - 1.315 1.358 0.149
ENSG00000183814 E017 23.6877766 0.0015369378 0.020206725 0.2369232 1 226267957 226268090 134 - 1.308 1.474 0.573
ENSG00000183814 E018 31.1784522 0.0008941645 0.292328524 0.6932533 1 226277775 226277932 158 - 1.475 1.542 0.229
ENSG00000183814 E019 26.6809213 0.0011735346 0.444083633 0.8000717 1 226286333 226286458 126 - 1.466 1.420 -0.158
ENSG00000183814 E020 12.2216172 0.0024241625 0.027247322 0.2679600 1 226287664 226287692 29 - 1.211 1.008 -0.733
ENSG00000183814 E021 20.2594803 0.0016191765 0.006509277 0.1420954 1 226287693 226287797 105 - 1.417 1.218 -0.695
ENSG00000183814 E022 16.4549618 0.0017188193 0.345703808 0.7358849 1 226295842 226295946 105 - 1.281 1.209 -0.252
ENSG00000183814 E023 19.7657070 0.0016972435 0.171856253 0.5693226 1 226297719 226297810 92 - 1.371 1.272 -0.345
ENSG00000183814 E024 10.4472968 0.0038693845 0.403009675 0.7755467 1 226297811 226297813 3 - 1.105 1.021 -0.304
ENSG00000183814 E025 11.9180401 0.0029463029 0.111073306 0.4774944 1 226301173 226301205 33 - 1.184 1.034 -0.541
ENSG00000183814 E026 0.8000913 0.0185105564 0.648861567   1 226308724 226309108 385 - 0.291 0.213 -0.589
ENSG00000183814 E027 10.5747299 0.0023890697 0.027268746 0.2680435 1 226309109 226309625 517 - 1.166 0.950 -0.786
ENSG00000183814 E028 1.2677863 0.0155392418 0.025785684   1 226309626 226310114 489 - 0.509 0.120 -2.811