ENSG00000183718

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000510796 ENSG00000183718 HEK293_DMSO_6hA HEK293_OSMI2_6hA TRIM52 protein_coding protein_coding 8.88898 8.049563 5.840543 2.076477 0.6489134 -0.462131 0.1607148 0.0000000 0.3543783 0.0000000 0.06037392 5.1873652 0.01925833 0.0000000 0.06470000 0.06470000 0.0001764696 0.0001764696 FALSE TRUE
ENST00000611618 ENSG00000183718 HEK293_DMSO_6hA HEK293_OSMI2_6hA TRIM52 protein_coding protein_coding 8.88898 8.049563 5.840543 2.076477 0.6489134 -0.462131 1.7815867 2.2248989 1.0257885 0.8258032 0.37057106 -1.1094802 0.20204167 0.2633667 0.16783333 -0.09553333 0.5424739464 0.0001764696 FALSE TRUE
ENST00000612671 ENSG00000183718 HEK293_DMSO_6hA HEK293_OSMI2_6hA TRIM52 protein_coding retained_intron 8.88898 8.049563 5.840543 2.076477 0.6489134 -0.462131 2.4888717 2.3631815 1.4267843 0.7260003 0.38500081 -0.7239789 0.25541250 0.2865333 0.23526667 -0.05126667 0.7526079794 0.0001764696 FALSE TRUE
ENST00000685507 ENSG00000183718 HEK293_DMSO_6hA HEK293_OSMI2_6hA TRIM52 protein_coding protein_coding 8.88898 8.049563 5.840543 2.076477 0.6489134 -0.462131 0.7220553 0.8460917 0.3134902 0.4666184 0.31349024 -1.4040431 0.08726667 0.1216667 0.06736667 -0.05430000 0.7317025412 0.0001764696 FALSE TRUE
ENST00000686030 ENSG00000183718 HEK293_DMSO_6hA HEK293_OSMI2_6hA TRIM52 protein_coding protein_coding 8.88898 8.049563 5.840543 2.076477 0.6489134 -0.462131 0.6553239 0.4923296 0.4334939 0.1599187 0.14671502 -0.1797199 0.07229583 0.0597000 0.07696667 0.01726667 0.9297153783 0.0001764696 FALSE TRUE
ENST00000688015 ENSG00000183718 HEK293_DMSO_6hA HEK293_OSMI2_6hA TRIM52 protein_coding protein_coding 8.88898 8.049563 5.840543 2.076477 0.6489134 -0.462131 2.5610493 1.5559729 1.8274726 0.3914134 0.43051636 0.2306634 0.31005417 0.2043333 0.31793333 0.11360000 0.6708199143 0.0001764696 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000183718 E001 0.1717682 0.0372237217 7.293423e-01   5 181254077 181254282 206 - 0.001 0.100 7.798
ENSG00000183718 E002 0.7531448 0.0187292609 3.699078e-01   5 181254417 181254985 569 - 0.334 0.182 -1.153
ENSG00000183718 E003 2.6678234 0.0168148427 5.447310e-01 0.852007492 5 181255147 181255173 27 - 0.611 0.524 -0.400
ENSG00000183718 E004 3.3280858 0.0075348375 8.990153e-01 0.975899252 5 181255174 181255181 8 - 0.612 0.641 0.129
ENSG00000183718 E005 9.2654798 0.0082362018 6.597720e-01 0.900506421 5 181255182 181255194 13 - 0.960 1.015 0.204
ENSG00000183718 E006 48.5087333 0.0012910098 1.916369e-01 0.593793971 5 181255195 181255399 205 - 1.628 1.707 0.268
ENSG00000183718 E007 237.2978104 0.0096216078 8.503956e-01 0.963119289 5 181255400 181256386 987 - 2.361 2.365 0.015
ENSG00000183718 E008 32.4957760 0.0022863401 2.339222e-02 0.251931064 5 181256387 181256515 129 - 1.594 1.467 -0.435
ENSG00000183718 E009 34.2157573 0.0035109063 9.119641e-01 0.978989008 5 181256516 181256649 134 - 1.535 1.540 0.019
ENSG00000183718 E010 51.1251920 0.0033434864 7.744463e-01 0.940738449 5 181256650 181256859 210 - 1.686 1.720 0.115
ENSG00000183718 E011 45.6327657 0.0018411839 3.733266e-01 0.755505725 5 181256860 181257054 195 - 1.619 1.683 0.218
ENSG00000183718 E012 45.1792975 0.0007320466 3.885730e-01 0.766135360 5 181257055 181257228 174 - 1.672 1.640 -0.111
ENSG00000183718 E013 50.4911566 0.0187287734 1.726888e-01 0.570137474 5 181257229 181257494 266 - 1.634 1.732 0.333
ENSG00000183718 E014 115.9518217 0.0185271734 1.927925e-01 0.594869882 5 181257495 181259260 1766 - 2.012 2.078 0.220
ENSG00000183718 E015 56.9378823 0.0005726526 1.052545e-01 0.467177413 5 181259261 181259906 646 - 1.693 1.782 0.300
ENSG00000183718 E016 22.3823155 0.0019745009 9.409142e-02 0.446259224 5 181259907 181260000 94 - 1.265 1.405 0.488
ENSG00000183718 E017 171.3894087 0.0003865414 2.380123e-05 0.005470287 5 181260001 181261150 1150 - 2.279 2.184 -0.319