ENSG00000183605

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000355697 ENSG00000183605 HEK293_DMSO_6hA HEK293_OSMI2_6hA SFXN4 protein_coding protein_coding 56.91294 56.9606 35.79135 6.223089 4.657293 -0.6702037 35.05519 33.61335 28.201343 2.807561 3.629250 -0.2531881 0.63884167 0.5954667 0.7908333 0.19536667 9.479455e-02 1.403812e-53 FALSE TRUE
MSTRG.4718.6 ENSG00000183605 HEK293_DMSO_6hA HEK293_OSMI2_6hA SFXN4 protein_coding   56.91294 56.9606 35.79135 6.223089 4.657293 -0.6702037 5.02885 10.28413 0.000000 1.388294 0.000000 -10.0076058 0.08891667 0.1808000 0.0000000 -0.18080000 1.403812e-53 1.403812e-53 FALSE TRUE
MSTRG.4718.7 ENSG00000183605 HEK293_DMSO_6hA HEK293_OSMI2_6hA SFXN4 protein_coding   56.91294 56.9606 35.79135 6.223089 4.657293 -0.6702037 13.88936 10.20726 4.455391 3.996011 2.795745 -1.1941505 0.21858750 0.1739667 0.1199000 -0.05406667 8.420393e-01 1.403812e-53 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000183605 E001 6.0280756 0.0068116379 0.05250816 0.35141224 10 119140767 119140912 146 - 0.970 0.728 -0.941
ENSG00000183605 E002 8.4340147 0.0042455345 0.50092136 0.83004959 10 119140913 119140927 15 - 0.990 0.916 -0.277
ENSG00000183605 E003 53.3399279 0.0029444021 0.87214253 0.96882538 10 119140928 119140964 37 - 1.692 1.706 0.049
ENSG00000183605 E004 55.8386343 0.0019265036 0.73409335 0.92708972 10 119140965 119140966 2 - 1.706 1.728 0.075
ENSG00000183605 E005 513.8537716 0.0003854839 0.47931664 0.81880537 10 119140967 119141255 289 - 2.669 2.682 0.044
ENSG00000183605 E006 335.3523725 0.0002442032 0.32886271 0.72358076 10 119141256 119141313 58 - 2.505 2.486 -0.063
ENSG00000183605 E007 208.7827179 0.0001863802 0.02726288 0.26801758 10 119141314 119141319 6 - 2.322 2.267 -0.182
ENSG00000183605 E008 16.8102171 0.0019680435 0.00151075 0.06858762 10 119142253 119142373 121 - 1.372 1.108 -0.933
ENSG00000183605 E009 324.6108856 0.0001200014 0.04813997 0.33922547 10 119146236 119146289 54 - 2.501 2.463 -0.128
ENSG00000183605 E010 333.5603525 0.0001604377 0.27674182 0.68051008 10 119146290 119146353 64 - 2.501 2.481 -0.068
ENSG00000183605 E011 173.5422746 0.0019271014 0.66085066 0.90086028 10 119147775 119147777 3 - 2.217 2.204 -0.043
ENSG00000183605 E012 384.9415312 0.0001176440 0.82978016 0.95684213 10 119147778 119147860 83 - 2.552 2.550 -0.007
ENSG00000183605 E013 522.3347012 0.0001098478 0.01497587 0.20844716 10 119155062 119155177 116 - 2.655 2.696 0.138
ENSG00000183605 E014 405.3865589 0.0001270396 0.01638448 0.21685752 10 119156678 119156756 79 - 2.541 2.588 0.155
ENSG00000183605 E015 159.7003864 0.0002073450 0.21739513 0.62197752 10 119157668 119157668 1 - 2.145 2.183 0.128
ENSG00000183605 E016 325.3515467 0.0001727431 0.16830686 0.56498585 10 119157669 119157733 65 - 2.457 2.487 0.101
ENSG00000183605 E017 331.9743308 0.0001169006 0.13850691 0.52306512 10 119157871 119157927 57 - 2.465 2.497 0.107
ENSG00000183605 E018 4.3399521 0.0775015738 0.37088725 0.75398225 10 119158007 119158008 2 - 0.810 0.640 -0.698
ENSG00000183605 E019 300.5478527 0.0001727597 0.52214496 0.84109389 10 119158009 119158062 54 - 2.434 2.449 0.050
ENSG00000183605 E020 221.5089188 0.0001696670 0.66976421 0.90407198 10 119159728 119159753 26 - 2.305 2.317 0.042
ENSG00000183605 E021 258.9752918 0.0001474969 0.09167753 0.44146786 10 119160915 119160969 55 - 2.404 2.367 -0.122
ENSG00000183605 E022 209.2604443 0.0002303022 0.06782220 0.39088146 10 119161055 119161081 27 - 2.317 2.272 -0.149
ENSG00000183605 E023 3.0886843 0.0132972168 0.50516781 0.83226475 10 119162139 119162160 22 - 0.639 0.533 -0.474
ENSG00000183605 E024 287.6261135 0.0001266073 0.08005532 0.41778375 10 119162340 119162414 75 - 2.447 2.411 -0.120
ENSG00000183605 E025 316.8279435 0.0026117391 0.91864555 0.98042033 10 119164131 119164196 66 - 2.476 2.469 -0.023
ENSG00000183605 E026 20.6210117 0.0037016554 0.04760313 0.33744180 10 119165202 119165536 335 - 1.396 1.234 -0.566
ENSG00000183605 E027 280.9662411 0.0049280932 0.49221966 0.82560056 10 119165537 119165632 96 - 2.410 2.427 0.056
ENSG00000183605 E028 167.1729271 0.0087723283 0.75965900 0.93576116 10 119165633 119165715 83 - 2.196 2.197 0.004
ENSG00000183605 E029 0.4901314 0.4094947742 1.00000000   10 119165934 119166019 86 - 0.155 0.168 0.142
ENSG00000183605 E030 0.0000000       10 119166020 119166189 170 -