ENSG00000182173

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000333213 ENSG00000182173 HEK293_DMSO_6hA HEK293_OSMI2_6hA TSEN54 protein_coding protein_coding 59.81214 54.36275 93.54955 5.336292 19.04609 0.7830011 18.186920 12.226438 41.587914 1.9866134 11.3895277 1.7653276 0.25813333 0.22423333 0.42736667 0.203133333 0.00304604 0.00304604 FALSE TRUE
ENST00000545228 ENSG00000182173 HEK293_DMSO_6hA HEK293_OSMI2_6hA TSEN54 protein_coding protein_coding 59.81214 54.36275 93.54955 5.336292 19.04609 0.7830011 4.033507 3.908035 6.227241 0.3123440 2.1492697 0.6707775 0.06791667 0.07236667 0.06203333 -0.010333333 0.75585349 0.00304604 FALSE TRUE
ENST00000579449 ENSG00000182173 HEK293_DMSO_6hA HEK293_OSMI2_6hA TSEN54 protein_coding retained_intron 59.81214 54.36275 93.54955 5.336292 19.04609 0.7830011 4.990711 8.484987 5.431673 0.5464644 1.8380018 -0.6425614 0.10691250 0.16046667 0.07450000 -0.085966667 0.27206292 0.00304604 TRUE TRUE
ENST00000583634 ENSG00000182173 HEK293_DMSO_6hA HEK293_OSMI2_6hA TSEN54 protein_coding retained_intron 59.81214 54.36275 93.54955 5.336292 19.04609 0.7830011 5.242115 3.442242 5.745323 1.2122672 1.9773619 0.7373633 0.09335000 0.06260000 0.05663333 -0.005966667 0.98951673 0.00304604   FALSE
ENST00000679443 ENSG00000182173 HEK293_DMSO_6hA HEK293_OSMI2_6hA TSEN54 protein_coding retained_intron 59.81214 54.36275 93.54955 5.336292 19.04609 0.7830011 2.053597 4.072968 1.504340 0.1868092 0.7960162 -1.4309287 0.04546667 0.07706667 0.02093333 -0.056133333 0.36605268 0.00304604 FALSE TRUE
MSTRG.15074.1 ENSG00000182173 HEK293_DMSO_6hA HEK293_OSMI2_6hA TSEN54 protein_coding   59.81214 54.36275 93.54955 5.336292 19.04609 0.7830011 3.888162 3.299272 5.386781 0.3075177 1.4860250 0.7055852 0.07228750 0.06080000 0.06603333 0.005233333 0.97616219 0.00304604 FALSE TRUE
MSTRG.15074.18 ENSG00000182173 HEK293_DMSO_6hA HEK293_OSMI2_6hA TSEN54 protein_coding   59.81214 54.36275 93.54955 5.336292 19.04609 0.7830011 8.154276 6.057037 9.224593 2.7949605 4.1068754 0.6060564 0.11420833 0.10436667 0.09080000 -0.013566667 0.90309675 0.00304604 FALSE TRUE
MSTRG.15074.6 ENSG00000182173 HEK293_DMSO_6hA HEK293_OSMI2_6hA TSEN54 protein_coding   59.81214 54.36275 93.54955 5.336292 19.04609 0.7830011 5.452130 3.858239 9.650668 0.7727706 4.0185054 1.3204461 0.08384167 0.07010000 0.09586667 0.025766667 0.74284227 0.00304604 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000182173 E001 0.4018037 2.287821e-02 0.1812938699   17 75515649 75515704 56 + 0.241 0.001 -9.028
ENSG00000182173 E002 7.3814700 8.804830e-02 0.4920377424 0.82553124 17 75515944 75516024 81 + 0.845 0.979 0.506
ENSG00000182173 E003 5.7239148 1.070766e-02 0.6837212187 0.90958040 17 75516025 75516059 35 + 0.777 0.850 0.289
ENSG00000182173 E004 10.6879022 2.879221e-03 0.0802294410 0.41808882 17 75516060 75516184 125 + 0.963 1.158 0.709
ENSG00000182173 E005 13.2976880 2.210498e-03 0.7278934129 0.92498537 17 75516185 75516386 202 + 1.119 1.170 0.183
ENSG00000182173 E006 1.1610252 1.329100e-02 0.1029137657   17 75516526 75516527 2 + 0.436 0.148 -2.094
ENSG00000182173 E007 3.5059267 8.534540e-02 0.0725161421 0.40124808 17 75516528 75516535 8 + 0.766 0.420 -1.566
ENSG00000182173 E008 4.0839381 9.384184e-02 0.0892897749 0.43722465 17 75516536 75516538 3 + 0.815 0.483 -1.436
ENSG00000182173 E009 11.1061931 7.706133e-02 0.1513349103 0.54116564 17 75516539 75516547 9 + 1.167 0.922 -0.899
ENSG00000182173 E010 13.5890227 1.060648e-01 0.1171248678 0.48836108 17 75516548 75516551 4 + 1.261 0.963 -1.074
ENSG00000182173 E011 20.5933714 8.595886e-02 0.0900242953 0.43855350 17 75516552 75516560 9 + 1.423 1.150 -0.957
ENSG00000182173 E012 73.3066787 9.546927e-03 0.0085113957 0.16080434 17 75516561 75516596 36 + 1.924 1.773 -0.506
ENSG00000182173 E013 85.4593648 8.414336e-03 0.0037467203 0.10969117 17 75516597 75516616 20 + 1.989 1.837 -0.509
ENSG00000182173 E014 155.7074116 2.035127e-03 0.0001096355 0.01419526 17 75516746 75516811 66 + 2.237 2.116 -0.404
ENSG00000182173 E015 117.5384941 2.279232e-03 0.0067369160 0.14467334 17 75516812 75516814 3 + 2.108 2.016 -0.307
ENSG00000182173 E016 225.9281918 6.199228e-03 0.0308870002 0.28281467 17 75516815 75516910 96 + 2.377 2.306 -0.236
ENSG00000182173 E017 18.3136634 1.584625e-03 0.0516117696 0.34875565 17 75516911 75516969 59 + 1.194 1.367 0.609
ENSG00000182173 E018 22.1080168 1.623194e-03 0.1581601988 0.55146390 17 75516970 75517008 39 + 1.303 1.424 0.422
ENSG00000182173 E019 160.9727874 2.586109e-03 0.0411403408 0.31779437 17 75517009 75517014 6 + 2.226 2.171 -0.182
ENSG00000182173 E020 266.2284782 7.717477e-04 0.0003266410 0.02805692 17 75517015 75517072 58 + 2.450 2.379 -0.236
ENSG00000182173 E021 9.5317093 2.507310e-03 0.0905942157 0.43976556 17 75517073 75517160 88 + 0.926 1.119 0.711
ENSG00000182173 E022 368.1540640 4.326222e-04 0.0029093274 0.09678430 17 75517161 75517244 84 + 2.581 2.539 -0.141
ENSG00000182173 E023 8.2794362 8.420045e-02 0.0152761355 0.21021755 17 75517245 75517475 231 + 0.728 1.157 1.619
ENSG00000182173 E024 509.7284163 1.076819e-04 0.0738701591 0.40384819 17 75517557 75517655 99 + 2.708 2.698 -0.031
ENSG00000182173 E025 282.7750911 1.716668e-03 0.8601672451 0.96574657 17 75518995 75519002 8 + 2.436 2.458 0.073
ENSG00000182173 E026 398.3535196 5.118243e-04 0.2483565639 0.65396892 17 75519003 75519047 45 + 2.596 2.594 -0.005
ENSG00000182173 E027 4.4582466 5.638160e-03 0.0584568054 0.36760776 17 75519755 75519944 190 + 0.599 0.874 1.127
ENSG00000182173 E028 9.0822792 2.001554e-01 0.4394070935 0.79730315 17 75521355 75521408 54 + 0.913 1.081 0.622
ENSG00000182173 E029 544.1940941 9.147643e-05 0.0970617845 0.45199536 17 75521409 75521510 102 + 2.733 2.727 -0.021
ENSG00000182173 E030 39.4527754 7.262051e-02 0.0070155232 0.14768064 17 75521511 75521675 165 + 1.395 1.787 1.336
ENSG00000182173 E031 18.4774487 2.284679e-02 0.0083548549 0.15943158 17 75521676 75521704 29 + 1.130 1.431 1.058
ENSG00000182173 E032 873.4202524 3.127101e-03 0.0557034051 0.36020275 17 75521705 75522006 302 + 2.944 2.921 -0.079
ENSG00000182173 E033 896.2571967 2.057870e-03 0.2665847808 0.67121386 17 75522007 75522333 327 + 2.945 2.948 0.007
ENSG00000182173 E034 144.4702566 3.455541e-02 0.0188527660 0.23018066 17 75522334 75522521 188 + 2.039 2.282 0.816
ENSG00000182173 E035 48.8403995 1.478283e-01 0.0345717393 0.29594557 17 75522522 75522535 14 + 1.494 1.873 1.287
ENSG00000182173 E036 134.8120204 1.267440e-01 0.0186269481 0.22911006 17 75522536 75522899 364 + 1.926 2.311 1.288
ENSG00000182173 E037 106.9496182 1.187591e-01 0.0377534437 0.30635836 17 75522900 75523151 252 + 1.858 2.191 1.117
ENSG00000182173 E038 71.2149717 9.766582e-02 0.0105928144 0.17807900 17 75523152 75523249 98 + 1.639 2.044 1.365
ENSG00000182173 E039 53.3275961 9.741848e-02 0.0332932477 0.29158030 17 75523250 75523274 25 + 1.555 1.895 1.151
ENSG00000182173 E040 355.7900923 4.293171e-04 0.0552371279 0.35903700 17 75523275 75523335 61 + 2.519 2.580 0.202
ENSG00000182173 E041 75.1821022 3.055846e-02 0.0196608064 0.23400483 17 75523336 75523662 327 + 1.757 2.000 0.820
ENSG00000182173 E042 575.3120577 8.379816e-04 0.5929079704 0.87258671 17 75523663 75523779 117 + 2.740 2.773 0.111
ENSG00000182173 E043 1148.5093611 2.664419e-03 0.5819320943 0.86762293 17 75524262 75524794 533 + 3.034 3.079 0.148