ENSG00000180104

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000315013 ENSG00000180104 HEK293_DMSO_6hA HEK293_OSMI2_6hA EXOC3 protein_coding protein_coding 27.21484 29.61193 35.29761 1.248818 3.661699 0.2533138 10.949543 13.736678 12.219599 1.3179724 2.023071 -0.168706 0.3815875 0.46336667 0.349833333 -0.1135333 0.4020971 0.0267496 FALSE TRUE
ENST00000509294 ENSG00000180104 HEK293_DMSO_6hA HEK293_OSMI2_6hA EXOC3 protein_coding processed_transcript 27.21484 29.61193 35.29761 1.248818 3.661699 0.2533138 1.017209 1.959231 0.202942 0.4261261 0.202942 -3.209100 0.0373250 0.06693333 0.007233333 -0.0597000 0.1347629 0.0267496 FALSE FALSE
ENST00000512944 ENSG00000180104 HEK293_DMSO_6hA HEK293_OSMI2_6hA EXOC3 protein_coding protein_coding 27.21484 29.61193 35.29761 1.248818 3.661699 0.2533138 9.673887 5.168928 15.333757 0.7784622 4.387466 1.566926 0.3690208 0.17326667 0.418266667 0.2450000 0.0267496 0.0267496 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000180104 E001 0.0000000       5 443175 443175 1 +      
ENSG00000180104 E002 3.4523814 0.0816640322 0.1876078441 0.58876062 5 443176 443232 57 + 0.732 0.494 -1.054
ENSG00000180104 E003 28.1565544 0.0009544398 0.0017015915 0.07321969 5 443233 443267 35 + 1.542 1.344 -0.682
ENSG00000180104 E004 39.5577715 0.0055475430 0.0001309299 0.01587145 5 443268 443290 23 + 1.704 1.459 -0.837
ENSG00000180104 E005 2.1915124 0.0087932558 0.4672262501 0.81253904 5 444926 445064 139 + 0.553 0.440 -0.554
ENSG00000180104 E006 0.1795728 0.0328905387 0.4149129233   5 446149 446149 1 + 0.000 0.131 9.766
ENSG00000180104 E007 168.7192685 0.0013781081 0.0402604756 0.31498707 5 446150 446349 200 + 2.254 2.198 -0.188
ENSG00000180104 E008 3.8353160 0.0080453570 0.0018190271 0.07586941 5 447018 447314 297 + 0.386 0.865 2.143
ENSG00000180104 E009 259.1022567 0.0013134981 0.4231901992 0.78804476 5 447533 447752 220 + 2.420 2.408 -0.041
ENSG00000180104 E010 118.7622055 0.0006180537 0.5403977989 0.85006055 5 453370 453396 27 + 2.062 2.093 0.102
ENSG00000180104 E011 613.6458960 0.0003717665 0.1781127390 0.57698096 5 453397 454051 655 + 2.791 2.781 -0.034
ENSG00000180104 E012 217.5302603 0.0002067386 0.5654851260 0.86019291 5 456889 457005 117 + 2.336 2.334 -0.009
ENSG00000180104 E013 105.7762780 0.0003066770 0.2064465961 0.61039533 5 457006 457006 1 + 1.998 2.052 0.181
ENSG00000180104 E014 25.9191699 0.0458757195 0.0092147911 0.16720780 5 457007 457899 893 + 1.243 1.563 1.109
ENSG00000180104 E015 230.1484264 0.0010083884 0.6815766209 0.90875611 5 457900 458025 126 + 2.360 2.360 -0.002
ENSG00000180104 E016 166.4323941 0.0003230816 0.2603558610 0.66580372 5 459359 459459 101 + 2.230 2.209 -0.069
ENSG00000180104 E017 14.3389139 0.0969774733 0.0227390132 0.24890036 5 459460 459580 121 + 0.961 1.340 1.357
ENSG00000180104 E018 33.2682822 0.0254867658 0.0004123528 0.03217070 5 461630 461959 330 + 1.325 1.680 1.220
ENSG00000180104 E019 207.7834024 0.0025919182 0.9413242982 0.98632574 5 461960 462070 111 + 2.313 2.320 0.023
ENSG00000180104 E020 244.9682304 0.0029487330 0.8459148318 0.96183332 5 462157 462307 151 + 2.383 2.391 0.024
ENSG00000180104 E021 11.1162938 0.0925139406 0.4276719152 0.79069552 5 462308 462529 222 + 1.024 1.150 0.457
ENSG00000180104 E022 223.0262480 0.0021498722 0.7667389421 0.93837565 5 464290 464412 123 + 2.343 2.347 0.015
ENSG00000180104 E023 30.9543790 0.1737237382 0.3573808482 0.74504529 5 464413 464788 376 + 1.454 1.547 0.320
ENSG00000180104 E024 29.2702078 0.1844045877 0.1927951493 0.59486988 5 464789 465110 322 + 1.375 1.567 0.660
ENSG00000180104 E025 273.4908213 0.0030270941 0.1246151768 0.50155427 5 465111 465272 162 + 2.451 2.414 -0.123
ENSG00000180104 E026 277.2748377 0.0002016188 0.0469326307 0.33577978 5 465718 465845 128 + 2.452 2.421 -0.104
ENSG00000180104 E027 8.1769277 0.0706485439 0.0328022302 0.29026821 5 465846 466078 233 + 0.755 1.101 1.310
ENSG00000180104 E028 485.1974860 0.0025809555 0.4367166587 0.79566238 5 466727 467290 564 + 2.689 2.682 -0.022
ENSG00000180104 E029 55.2897625 0.0534033933 0.3539215904 0.74243604 5 467291 468609 1319 + 1.699 1.796 0.329
ENSG00000180104 E030 17.5308866 0.0776552183 0.5916982548 0.87207136 5 468870 468942 73 + 1.231 1.294 0.221
ENSG00000180104 E031 12.7563242 0.0211813103 0.9589066640 0.99056160 5 469438 469547 110 + 1.132 1.147 0.055
ENSG00000180104 E032 16.9332069 0.0017112835 0.1211027733 0.49567577 5 469631 469789 159 + 1.177 1.315 0.486
ENSG00000180104 E033 22.7613520 0.0159034296 0.3888990711 0.76631741 5 469790 469855 66 + 1.326 1.415 0.309
ENSG00000180104 E034 38.8952871 0.0100194317 0.0100345780 0.17382426 5 469856 469987 132 + 1.491 1.688 0.671
ENSG00000180104 E035 24.0781427 0.0470553537 0.0602536797 0.37221163 5 471099 471122 24 + 1.269 1.507 0.824
ENSG00000180104 E036 127.9728513 0.0430570210 0.0463895645 0.33403591 5 471123 471937 815 + 2.001 2.203 0.676