ENSG00000179846

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000317951 ENSG00000179846 HEK293_DMSO_6hA HEK293_OSMI2_6hA NKPD1 protein_coding protein_coding 0.1416331 0.2050294 0.2469684 0.03972044 0.009486193 0.2570572 0.032616965 0.19461442 0.0000000 0.04390701 0.000000000 -4.354836 0.2428417 0.94273333 0 -0.94273333 1.248188e-04 7.068515e-05 FALSE TRUE
ENST00000589776 ENSG00000179846 HEK293_DMSO_6hA HEK293_OSMI2_6hA NKPD1 protein_coding protein_coding 0.1416331 0.2050294 0.2469684 0.03972044 0.009486193 0.2570572 0.007252884 0.01041496 0.0000000 0.01041496 0.000000000 -1.029627 0.0257125 0.05726667 0 -0.05726667 7.603983e-01 7.068515e-05 FALSE TRUE
ENST00000686631 ENSG00000179846 HEK293_DMSO_6hA HEK293_OSMI2_6hA NKPD1 protein_coding protein_coding 0.1416331 0.2050294 0.2469684 0.03972044 0.009486193 0.2570572 0.101763249 0.00000000 0.2469684 0.00000000 0.009486193 4.683519 0.7314458 0.00000000 1 1.00000000 7.068515e-05 7.068515e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000179846 E001 0.2669773 0.02907852 0.975060460   19 45149744 45149749 6 - 0.117 0.122 0.061
ENSG00000179846 E002 17.9731855 0.02444117 0.440274133 0.79797640 19 45149750 45151902 2153 - 1.305 1.248 -0.199
ENSG00000179846 E003 12.2569887 0.01086478 0.120975642 0.49544641 19 45151903 45153775 1873 - 1.184 1.055 -0.463
ENSG00000179846 E004 0.2842848 0.02989946 0.971469087   19 45153776 45153852 77 - 0.117 0.122 0.062
ENSG00000179846 E005 1.1508694 0.01605986 0.225970798   19 45155785 45155916 132 - 0.210 0.418 1.381
ENSG00000179846 E006 0.6965146 0.68366153 0.609479306   19 45158663 45159100 438 - 0.122 0.297 1.597
ENSG00000179846 E007 1.3989019 0.01486204 0.074556377   19 45160060 45160221 162 - 0.209 0.514 1.869
ENSG00000179846 E008 1.8062167 0.01274318 0.002824919 0.09548167 19 45160664 45160924 261 - 0.118 0.626 3.377
ENSG00000179846 E009 0.1767706 0.03470383 0.505006072   19 45160925 45160982 58 - 0.118 0.000 -9.189