ENSG00000178921

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000314666 ENSG00000178921 HEK293_DMSO_6hA HEK293_OSMI2_6hA PFAS protein_coding protein_coding 62.54509 62.30549 87.26981 5.148888 8.42304 0.4860573 38.293450 33.564727 58.893125 3.0567467 7.758378 0.8109685 0.61479583 0.5379 0.66966667 0.13176667 0.003604681 0.003604681 FALSE TRUE
ENST00000546020 ENSG00000178921 HEK293_DMSO_6hA HEK293_OSMI2_6hA PFAS protein_coding protein_coding 62.54509 62.30549 87.26981 5.148888 8.42304 0.4860573 7.553301 9.070738 9.950459 0.4896015 1.745585 0.1334027 0.10808750 0.1468 0.11283333 -0.03396667 0.411301323 0.003604681 FALSE TRUE
ENST00000580251 ENSG00000178921 HEK293_DMSO_6hA HEK293_OSMI2_6hA PFAS protein_coding retained_intron 62.54509 62.30549 87.26981 5.148888 8.42304 0.4860573 4.864095 6.919830 5.319730 0.7880951 1.458386 -0.3787573 0.08355417 0.1108 0.06583333 -0.04496667 0.354095581 0.003604681   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000178921 E001 15.2560902 2.991607e-03 0.755937751 0.93458604 17 8247618 8247856 239 + 1.185 1.220 0.125
ENSG00000178921 E002 3.2124311 6.655935e-03 0.296856566 0.69712780 17 8249274 8249283 10 + 0.673 0.516 -0.701
ENSG00000178921 E003 3.3841993 6.324155e-03 0.449865497 0.80347212 17 8249284 8249285 2 + 0.673 0.564 -0.478
ENSG00000178921 E004 4.1731207 5.574753e-03 0.479662477 0.81901278 17 8249286 8249288 3 + 0.740 0.645 -0.396
ENSG00000178921 E005 3.9963502 5.732455e-03 0.581378458 0.86745648 17 8249289 8249290 2 + 0.719 0.645 -0.308
ENSG00000178921 E006 202.1623520 4.465962e-03 0.926602009 0.98259484 17 8249291 8249339 49 + 2.297 2.310 0.044
ENSG00000178921 E007 2.6625434 8.611928e-02 0.618188478 0.88323743 17 8249342 8249505 164 + 0.498 0.608 0.505
ENSG00000178921 E008 4.7249821 5.293758e-03 0.070267240 0.39631263 17 8253842 8253858 17 + 0.621 0.873 1.024
ENSG00000178921 E009 346.6545116 2.952004e-03 0.517185802 0.83874734 17 8253859 8253937 79 + 2.523 2.553 0.098
ENSG00000178921 E010 473.5101076 2.487899e-03 0.468462646 0.81319553 17 8253938 8254079 142 + 2.658 2.688 0.099
ENSG00000178921 E011 370.5913430 3.186800e-04 0.880465008 0.97132627 17 8254166 8254301 136 + 2.558 2.569 0.037
ENSG00000178921 E012 312.2746324 1.397362e-04 0.329329363 0.72395188 17 8255027 8255132 106 + 2.479 2.507 0.091
ENSG00000178921 E013 378.7307142 1.347662e-04 0.043694737 0.32568860 17 8255502 8255691 190 + 2.586 2.556 -0.100
ENSG00000178921 E014 300.0353746 1.634394e-04 0.053478908 0.35415563 17 8255805 8255910 106 + 2.490 2.457 -0.110
ENSG00000178921 E015 444.0790636 1.199266e-04 0.056792763 0.36326062 17 8256267 8256407 141 + 2.654 2.629 -0.083
ENSG00000178921 E016 10.4983609 2.157631e-01 0.413535096 0.78253508 17 8256408 8256523 116 + 0.986 1.122 0.497
ENSG00000178921 E017 439.3167418 5.633218e-04 0.336451185 0.72923574 17 8256524 8256648 125 + 2.645 2.635 -0.035
ENSG00000178921 E018 359.5531344 1.053433e-04 0.840191039 0.96035174 17 8256835 8256963 129 + 2.548 2.559 0.038
ENSG00000178921 E019 328.2163263 1.171969e-04 0.269361551 0.67389799 17 8257807 8257938 132 + 2.519 2.504 -0.048
ENSG00000178921 E020 388.1081999 1.010685e-04 0.052026946 0.34992848 17 8258071 8258199 129 + 2.597 2.569 -0.093
ENSG00000178921 E021 0.4856919 4.882414e-01 0.523216469   17 8262460 8262499 40 + 0.105 0.242 1.452
ENSG00000178921 E022 368.7432541 2.352847e-04 0.355456750 0.74368945 17 8262920 8262987 68 + 2.566 2.556 -0.034
ENSG00000178921 E023 241.1171251 1.654894e-04 0.416241673 0.78422557 17 8262988 8262993 6 + 2.366 2.393 0.088
ENSG00000178921 E024 544.3798180 1.086012e-04 0.150380103 0.53990344 17 8263109 8263260 152 + 2.737 2.723 -0.050
ENSG00000178921 E025 215.5531233 2.137313e-04 0.096491077 0.45080041 17 8263261 8263265 5 + 2.348 2.314 -0.114
ENSG00000178921 E026 336.9714277 1.309486e-04 0.007952420 0.15590910 17 8263575 8263636 62 + 2.544 2.499 -0.150
ENSG00000178921 E027 535.5612944 8.848662e-05 0.422564314 0.78758824 17 8263775 8263936 162 + 2.728 2.723 -0.017
ENSG00000178921 E028 398.5281303 1.079869e-04 0.098937262 0.45523393 17 8264212 8264337 126 + 2.607 2.585 -0.074
ENSG00000178921 E029 285.9701015 1.363565e-04 0.005395962 0.13132023 17 8264470 8264601 132 + 2.475 2.423 -0.173
ENSG00000178921 E030 15.6234492 2.319962e-01 0.126624246 0.50512222 17 8264602 8264641 40 + 1.086 1.336 0.888
ENSG00000178921 E031 610.8338365 2.145837e-04 0.002611838 0.09167657 17 8264895 8265125 231 + 2.799 2.760 -0.129
ENSG00000178921 E032 699.8280643 3.090849e-04 0.062441335 0.37818014 17 8265288 8265468 181 + 2.850 2.830 -0.066
ENSG00000178921 E033 483.8931319 5.291899e-04 0.862816743 0.96658160 17 8265556 8265639 84 + 2.677 2.689 0.041
ENSG00000178921 E034 559.3122573 8.895020e-05 0.659763002 0.90050642 17 8265862 8265972 111 + 2.737 2.752 0.048
ENSG00000178921 E035 341.6647038 1.324417e-04 0.261850393 0.66709569 17 8265973 8266005 33 + 2.518 2.547 0.098
ENSG00000178921 E036 280.0919198 8.362154e-04 0.756388619 0.93465056 17 8266006 8266017 12 + 2.440 2.455 0.051
ENSG00000178921 E037 382.7514288 1.106181e-04 0.874594823 0.96971554 17 8266234 8266271 38 + 2.578 2.583 0.015
ENSG00000178921 E038 547.6530841 1.549015e-04 0.247726935 0.65322970 17 8266272 8266353 82 + 2.740 2.729 -0.035
ENSG00000178921 E039 18.8360751 7.027492e-02 0.179577974 0.57874064 17 8266501 8266752 252 + 1.201 1.385 0.644
ENSG00000178921 E040 729.9786237 1.034976e-03 0.951003350 0.98855127 17 8266753 8266898 146 + 2.852 2.867 0.049
ENSG00000178921 E041 69.9296674 6.166398e-02 0.031881079 0.28674456 17 8266899 8267027 129 + 1.712 1.972 0.877
ENSG00000178921 E042 887.1372873 1.036965e-04 0.865645707 0.96717292 17 8267028 8267226 199 + 2.940 2.946 0.021
ENSG00000178921 E043 327.5537200 1.393408e-04 0.542079319 0.85084303 17 8267227 8267235 9 + 2.511 2.507 -0.014
ENSG00000178921 E044 608.6434661 1.463571e-04 0.582535685 0.86788104 17 8267372 8267463 92 + 2.774 2.790 0.055
ENSG00000178921 E045 687.3476561 7.705348e-05 0.299607938 0.69961041 17 8267551 8267665 115 + 2.823 2.845 0.074
ENSG00000178921 E046 944.7989779 1.148693e-03 0.347749938 0.73759753 17 8268533 8268856 324 + 2.957 2.988 0.104
ENSG00000178921 E047 20.4418465 6.251873e-02 0.184854508 0.58543031 17 8268857 8268953 97 + 1.229 1.428 0.694
ENSG00000178921 E048 2942.3417871 1.514232e-03 0.036383206 0.30182928 17 8268954 8270491 1538 + 3.444 3.491 0.157