ENSG00000178188

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000359285 ENSG00000178188 HEK293_DMSO_6hA HEK293_OSMI2_6hA SH2B1 protein_coding protein_coding 33.99342 47.71699 49.26535 0.6561322 3.039046 0.04606049 3.737795 4.057992 6.880954 0.4279632 2.3461772 0.7603868 0.10167083 0.08486667 0.14223333 0.05736667 0.74795531 4.850247e-06 FALSE TRUE
ENST00000395532 ENSG00000178188 HEK293_DMSO_6hA HEK293_OSMI2_6hA SH2B1 protein_coding protein_coding 33.99342 47.71699 49.26535 0.6561322 3.039046 0.04606049 2.255436 1.929436 4.211842 0.5636071 0.7138585 1.1222352 0.06143333 0.04010000 0.08703333 0.04693333 0.31850069 4.850247e-06 FALSE TRUE
ENST00000563674 ENSG00000178188 HEK293_DMSO_6hA HEK293_OSMI2_6hA SH2B1 protein_coding processed_transcript 33.99342 47.71699 49.26535 0.6561322 3.039046 0.04606049 2.488080 4.932365 2.603565 0.1698724 0.5078246 -0.9191827 0.07483750 0.10343333 0.05193333 -0.05150000 0.02488703 4.850247e-06   TRUE
ENST00000568868 ENSG00000178188 HEK293_DMSO_6hA HEK293_OSMI2_6hA SH2B1 protein_coding protein_coding 33.99342 47.71699 49.26535 0.6561322 3.039046 0.04606049 4.402850 9.998911 5.423938 0.6448949 3.6486950 -0.8812149 0.13395000 0.20950000 0.10636667 -0.10313333 0.29945319 4.850247e-06 FALSE FALSE
ENST00000684370 ENSG00000178188 HEK293_DMSO_6hA HEK293_OSMI2_6hA SH2B1 protein_coding protein_coding 33.99342 47.71699 49.26535 0.6561322 3.039046 0.04606049 2.269244 3.892499 3.406400 0.7512472 0.7786588 -0.1919216 0.07271250 0.08203333 0.06860000 -0.01343333 0.79921706 4.850247e-06 FALSE TRUE
MSTRG.12369.22 ENSG00000178188 HEK293_DMSO_6hA HEK293_OSMI2_6hA SH2B1 protein_coding   33.99342 47.71699 49.26535 0.6561322 3.039046 0.04606049 2.696592 3.677003 4.816367 0.3948091 0.7972435 0.3884891 0.07967083 0.07690000 0.09700000 0.02010000 0.72092719 4.850247e-06 FALSE TRUE
MSTRG.12369.23 ENSG00000178188 HEK293_DMSO_6hA HEK293_OSMI2_6hA SH2B1 protein_coding   33.99342 47.71699 49.26535 0.6561322 3.039046 0.04606049 3.837319 5.544427 5.045443 0.1234157 0.5804568 -0.1358004 0.12083333 0.11620000 0.10170000 -0.01450000 0.74132122 4.850247e-06 FALSE TRUE
MSTRG.12369.25 ENSG00000178188 HEK293_DMSO_6hA HEK293_OSMI2_6hA SH2B1 protein_coding   33.99342 47.71699 49.26535 0.6561322 3.039046 0.04606049 2.950952 3.264643 4.896188 0.6813916 0.8776053 0.5832648 0.08908333 0.06806667 0.09833333 0.03026667 0.56666567 4.850247e-06 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000178188 E001 0.3312313 0.0314027083 9.505488e-01   16 28846543 28846563 21 + 0.114 0.126 0.168
ENSG00000178188 E002 0.3312313 0.0314027083 9.505488e-01   16 28846564 28846599 36 + 0.114 0.126 0.168
ENSG00000178188 E003 0.3312313 0.0314027083 9.505488e-01   16 28846600 28846604 5 + 0.114 0.126 0.168
ENSG00000178188 E004 1.3220355 0.0161637111 5.617922e-01   16 28846605 28846642 38 + 0.397 0.303 -0.569
ENSG00000178188 E005 5.7649357 0.0043001506 2.907567e-01 0.692113382 16 28846643 28846685 43 + 0.879 0.757 -0.481
ENSG00000178188 E006 6.0492205 0.0039520652 3.110274e-01 0.708799783 16 28846686 28846688 3 + 0.896 0.782 -0.445
ENSG00000178188 E007 11.5990233 0.0034054561 1.514735e-01 0.541342569 16 28846689 28846827 139 + 1.159 1.032 -0.462
ENSG00000178188 E008 0.3089214 0.4588023657 2.869953e-01   16 28851514 28851625 112 + 0.000 0.220 10.507
ENSG00000178188 E009 2.3534538 0.0515402109 1.778127e-01 0.576628254 16 28861618 28861620 3 + 0.395 0.639 1.179
ENSG00000178188 E010 7.7265443 0.0081047199 2.113705e-01 0.615872887 16 28861621 28861747 127 + 0.861 1.017 0.587
ENSG00000178188 E011 8.7805892 0.0351738238 2.940681e-01 0.694680116 16 28862804 28863029 226 + 0.913 1.057 0.537
ENSG00000178188 E012 7.8164271 0.1089964248 8.645667e-02 0.430760054 16 28863030 28863166 137 + 0.773 1.079 1.157
ENSG00000178188 E013 6.5868184 0.0037350979 2.322094e-01 0.637211052 16 28863167 28863289 123 + 0.804 0.958 0.589
ENSG00000178188 E014 4.6221492 0.0046962823 4.342545e-01 0.793976567 16 28863290 28863306 17 + 0.688 0.805 0.472
ENSG00000178188 E015 5.8450772 0.0039061406 2.153207e-01 0.619942731 16 28863307 28863345 39 + 0.739 0.907 0.658
ENSG00000178188 E016 25.2746604 0.0036863858 5.153543e-02 0.348527378 16 28863346 28863558 213 + 1.324 1.481 0.544
ENSG00000178188 E017 36.5580829 0.0023407177 8.267739e-01 0.956004023 16 28863559 28863667 109 + 1.567 1.568 0.003
ENSG00000178188 E018 42.4661545 0.0007323953 6.125940e-02 0.374850160 16 28863668 28863754 87 + 1.675 1.588 -0.297
ENSG00000178188 E019 2.6903968 0.0261357148 8.848357e-01 0.972483599 16 28863755 28863756 2 + 0.532 0.568 0.167
ENSG00000178188 E020 4.0929586 0.0827618576 3.081233e-01 0.706451908 16 28863757 28863804 48 + 0.573 0.786 0.897
ENSG00000178188 E021 2.9354497 0.3726362163 3.238514e-01 0.719966935 16 28863805 28863805 1 + 0.407 0.713 1.420
ENSG00000178188 E022 5.5752977 0.0043341363 3.581956e-01 0.745563522 16 28863806 28863842 37 + 0.739 0.869 0.512
ENSG00000178188 E023 11.7278996 0.0024953025 5.256006e-01 0.842876001 16 28863843 28863877 35 + 1.131 1.083 -0.175
ENSG00000178188 E024 23.3220768 0.0120632999 3.892074e-01 0.766467865 16 28863878 28863945 68 + 1.423 1.359 -0.221
ENSG00000178188 E025 9.2194783 0.0756022908 1.366095e-01 0.520412460 16 28863946 28863974 29 + 0.870 1.107 0.876
ENSG00000178188 E026 17.9441936 0.0142722815 4.862446e-01 0.822629857 16 28863975 28863997 23 + 1.299 1.243 -0.197
ENSG00000178188 E027 69.2054682 0.0113176332 6.197906e-01 0.883961875 16 28863998 28864187 190 + 1.826 1.864 0.129
ENSG00000178188 E028 57.3218034 0.0218665341 1.859209e-01 0.586680449 16 28864188 28864262 75 + 1.708 1.818 0.373
ENSG00000178188 E029 66.4564690 0.0189198647 8.649823e-02 0.430850536 16 28864263 28864338 76 + 1.755 1.892 0.462
ENSG00000178188 E030 428.3078041 0.0365740037 5.446525e-02 0.356992284 16 28864339 28865624 1286 + 2.545 2.706 0.535
ENSG00000178188 E031 98.8181434 0.0753826668 8.004484e-02 0.417781670 16 28865625 28866011 387 + 1.881 2.092 0.709
ENSG00000178188 E032 584.7143873 0.0013236501 2.953884e-02 0.277678341 16 28866012 28866634 623 + 2.782 2.752 -0.101
ENSG00000178188 E033 257.5857218 0.0046502182 1.241072e-01 0.500714348 16 28866635 28866677 43 + 2.431 2.392 -0.132
ENSG00000178188 E034 659.7558548 0.0006408773 3.642981e-02 0.301899568 16 28866678 28867033 356 + 2.830 2.809 -0.070
ENSG00000178188 E035 11.0173431 0.4135175810 7.665066e-02 0.410542293 16 28867154 28867330 177 + 0.882 1.210 1.202
ENSG00000178188 E036 243.3906476 0.0001736312 4.405246e-01 0.798082225 16 28867331 28867373 43 + 2.390 2.386 -0.014
ENSG00000178188 E037 297.6886835 0.0006148140 3.038102e-01 0.702977797 16 28867374 28867432 59 + 2.480 2.470 -0.033
ENSG00000178188 E038 307.3976565 0.0001752278 8.279475e-01 0.956371153 16 28869006 28869093 88 + 2.483 2.492 0.031
ENSG00000178188 E039 169.4816872 0.0011609099 5.755871e-01 0.864661673 16 28869094 28869097 4 + 2.230 2.228 -0.006
ENSG00000178188 E040 265.5827479 0.0017751528 1.937353e-01 0.596013804 16 28869208 28869276 69 + 2.435 2.414 -0.072
ENSG00000178188 E041 310.6381755 0.0004548217 4.986385e-03 0.126694461 16 28869277 28869383 107 + 2.516 2.469 -0.158
ENSG00000178188 E042 360.0917402 0.0001474883 2.124443e-03 0.082303378 16 28871780 28871983 204 + 2.577 2.534 -0.146
ENSG00000178188 E043 21.5251242 0.0261220147 5.954086e-03 0.137015098 16 28871984 28872189 206 + 1.174 1.472 1.039
ENSG00000178188 E044 161.3534265 0.0025714570 7.390594e-01 0.928757863 16 28872190 28872206 17 + 2.210 2.212 0.009
ENSG00000178188 E045 232.3008627 0.0018108037 1.483767e-01 0.536853606 16 28872207 28872252 46 + 2.382 2.353 -0.096
ENSG00000178188 E046 325.3412721 0.0001373081 1.045292e-01 0.465880637 16 28872253 28872339 87 + 2.521 2.503 -0.061
ENSG00000178188 E047 326.1687686 0.0001553150 8.585439e-01 0.965297533 16 28872340 28872401 62 + 2.508 2.518 0.034
ENSG00000178188 E048 476.2986355 0.0001345075 7.384904e-01 0.928517596 16 28872534 28872705 172 + 2.666 2.685 0.064
ENSG00000178188 E049 86.1806045 0.0059932881 3.951910e-01 0.770098755 16 28872706 28872758 53 + 1.904 1.965 0.207
ENSG00000178188 E050 30.0334349 0.0922207231 1.748818e-02 0.223296888 16 28872759 28872813 55 + 1.290 1.626 1.156
ENSG00000178188 E051 57.8456832 0.0177923556 3.588523e-05 0.007096069 16 28872928 28873169 242 + 1.567 1.905 1.145
ENSG00000178188 E052 292.6871500 0.0001440709 2.227508e-01 0.627463860 16 28873170 28873269 100 + 2.446 2.485 0.129
ENSG00000178188 E053 776.7170680 0.0014649784 8.450856e-01 0.961597936 16 28873447 28874212 766 + 2.885 2.897 0.039