ENSG00000175567

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000663595 ENSG00000175567 HEK293_DMSO_6hA HEK293_OSMI2_6hA UCP2 protein_coding protein_coding 60.41104 28.82597 82.63339 3.533452 23.02586 1.51903 57.4376 25.5286 78.66467 3.497947 22.17079 1.62322 0.9416875 0.8821333 0.9488333 0.0667 0.03431001 0.03431001 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000175567 E001 26.9209845 0.0061078491 0.778266959 0.94185836 11 73974672 73974678 7 - 1.404 1.437 0.112
ENSG00000175567 E002 91.1845843 0.0003380223 0.111500282 0.47828226 11 73974679 73974708 30 - 1.914 1.975 0.205
ENSG00000175567 E003 351.1372875 0.0006825855 0.081879623 0.42169836 11 73974709 73974851 143 - 2.500 2.543 0.144
ENSG00000175567 E004 737.5016160 0.0001341191 0.196030452 0.59913327 11 73974852 73975121 270 - 2.834 2.851 0.059
ENSG00000175567 E005 263.5276693 0.0023448307 0.355696659 0.74386518 11 73975491 73975529 39 - 2.381 2.415 0.114
ENSG00000175567 E006 472.5019388 0.0013247925 0.754064045 0.93378946 11 73975530 73975632 103 - 2.645 2.639 -0.017
ENSG00000175567 E007 350.2069139 0.0001346186 0.279851991 0.68317004 11 73975633 73975671 39 - 2.525 2.500 -0.081
ENSG00000175567 E008 453.0562714 0.0001411150 0.194769666 0.59748745 11 73976641 73976742 102 - 2.636 2.611 -0.082
ENSG00000175567 E009 526.8790511 0.0001378683 0.098927479 0.45523393 11 73976823 73977017 195 - 2.702 2.673 -0.096
ENSG00000175567 E010 6.7707477 0.2254411593 0.261522497 0.66677745 11 73977018 73977064 47 - 0.756 1.016 0.994
ENSG00000175567 E011 484.4279595 0.0004023790 0.016408964 0.21700913 11 73977886 73978096 211 - 2.668 2.623 -0.150
ENSG00000175567 E012 3.8984951 0.0466346620 0.019704233 0.23417022 11 73978097 73978141 45 - 0.499 0.887 1.637
ENSG00000175567 E013 4.8704155 0.0075109880 0.001232369 0.06105073 11 73978191 73978252 62 - 0.548 0.990 1.789
ENSG00000175567 E014 243.2137174 0.0002003311 0.669576291 0.90401649 11 73978253 73978280 28 - 2.361 2.349 -0.039
ENSG00000175567 E015 490.7743748 0.0001010354 0.524933903 0.84251464 11 73978281 73978477 197 - 2.665 2.653 -0.040
ENSG00000175567 E016 0.5325511 0.0207395269 0.163688347   11 73978577 73978695 119 - 0.077 0.308 2.402
ENSG00000175567 E017 0.1125166 0.0326491905 1.000000000   11 73978696 73978834 139 - 0.077 0.000 -7.982
ENSG00000175567 E018 0.9842546 0.0144752205 0.424653839   11 73979936 73980014 79 - 0.336 0.181 -1.178
ENSG00000175567 E019 0.7343511 0.3544697400 0.857903154   11 73980015 73980052 38 - 0.275 0.181 -0.775
ENSG00000175567 E020 0.7950889 0.0168896471 0.132222722   11 73980672 73980938 267 - 0.143 0.406 1.989
ENSG00000175567 E021 0.8230033 0.0436179875 0.018361699   11 73981148 73981475 328 - 0.077 0.487 3.413
ENSG00000175567 E022 439.9325334 0.0005570677 0.376409817 0.75761814 11 73981476 73981632 157 - 2.605 2.628 0.078
ENSG00000175567 E023 215.7289852 0.0023586985 0.390078641 0.76702552 11 73982721 73982737 17 - 2.289 2.330 0.137
ENSG00000175567 E024 236.4103647 0.0046509708 0.823419759 0.95538341 11 73982738 73982865 128 - 2.331 2.358 0.090