ENSG00000175354

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000327283 ENSG00000175354 HEK293_DMSO_6hA HEK293_OSMI2_6hA PTPN2 protein_coding protein_coding 18.73919 9.387269 12.55637 2.158975 2.718099 0.4192544 14.1723565 6.309933 10.4083204 1.6195953 2.3418437 0.7211415 0.75425417 0.6648000 0.8236333 0.15883333 0.01239566 0.01239566 FALSE TRUE
ENST00000589444 ENSG00000175354 HEK293_DMSO_6hA HEK293_OSMI2_6hA PTPN2 protein_coding retained_intron 18.73919 9.387269 12.55637 2.158975 2.718099 0.4192544 0.7959075 1.409738 0.6754377 0.2615167 0.1301494 -1.0505277 0.05043333 0.1529333 0.0586000 -0.09433333 0.10035823 0.01239566   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000175354 E001 0.8827271 0.3637582787 8.358074e-01   18 12785478 12785480 3 - 0.267 0.245 -0.161
ENSG00000175354 E002 0.8827271 0.3637582787 8.358074e-01   18 12785481 12785482 2 - 0.267 0.245 -0.161
ENSG00000175354 E003 1.4434310 0.0213782810 5.789963e-01   18 12785483 12785505 23 - 0.415 0.329 -0.503
ENSG00000175354 E004 55.2230593 0.0005844329 9.564557e-02 0.449473407 18 12785506 12785684 179 - 1.712 1.806 0.316
ENSG00000175354 E005 94.0745341 0.0007150333 1.539776e-01 0.544841375 18 12785685 12785844 160 - 1.955 2.023 0.227
ENSG00000175354 E006 61.8623882 0.0460937238 2.114847e-05 0.005086345 18 12785845 12787741 1897 - 1.501 2.003 1.698
ENSG00000175354 E007 4.0831313 0.0253380446 2.167899e-01 0.621530541 18 12788065 12788150 86 - 0.595 0.798 0.846
ENSG00000175354 E008 2.9411820 0.0304598296 3.346133e-03 0.104232754 18 12792152 12792301 150 - 0.314 0.821 2.409
ENSG00000175354 E009 9.5533118 0.1330596811 3.638361e-01 0.749562132 18 12792302 12793481 1180 - 0.932 1.122 0.695
ENSG00000175354 E010 3.2880207 0.0379106520 4.632131e-01 0.810308269 18 12793482 12793574 93 - 0.589 0.712 0.526
ENSG00000175354 E011 3.8240800 0.2221423803 7.994307e-01 0.948124220 18 12793575 12793834 260 - 0.677 0.681 0.019
ENSG00000175354 E012 10.6168324 0.0034844241 1.214700e-01 0.496242243 18 12793835 12794111 277 - 0.979 1.152 0.630
ENSG00000175354 E013 15.1060023 0.0049413021 8.517580e-01 0.963317988 18 12794112 12794383 272 - 1.200 1.235 0.124
ENSG00000175354 E014 86.5965337 0.0005127335 9.652936e-01 0.992056030 18 12794384 12794485 102 - 1.943 1.961 0.062
ENSG00000175354 E015 61.0505939 0.0045041856 8.549867e-01 0.964189657 18 12801970 12801988 19 - 1.790 1.805 0.051
ENSG00000175354 E016 116.6891751 0.0020266172 4.506704e-01 0.804024092 18 12801989 12802151 163 - 2.080 2.073 -0.023
ENSG00000175354 E017 0.1795728 0.0484145059 3.731783e-01   18 12802152 12802153 2 - 0.000 0.139 11.024
ENSG00000175354 E018 0.0000000       18 12814197 12814202 6 -      
ENSG00000175354 E019 95.1111600 0.0004069937 1.269072e-01 0.505606890 18 12814203 12814324 122 - 2.005 1.970 -0.119
ENSG00000175354 E020 60.8452379 0.0004984491 9.026106e-02 0.439122073 18 12814325 12814355 31 - 1.826 1.768 -0.194
ENSG00000175354 E021 57.7733761 0.0005652211 2.857381e-02 0.273912915 18 12817156 12817180 25 - 1.815 1.733 -0.276
ENSG00000175354 E022 74.1448694 0.0004966559 1.396746e-01 0.524616247 18 12817181 12817265 85 - 1.907 1.865 -0.140
ENSG00000175354 E023 65.8810753 0.0013905545 3.070419e-02 0.282101945 18 12817266 12817365 100 - 1.867 1.790 -0.261
ENSG00000175354 E024 0.7057227 0.0180036372 4.326659e-01   18 12818944 12819213 270 - 0.185 0.328 1.089
ENSG00000175354 E025 0.3794938 0.0263260225 7.729743e-01   18 12819214 12819282 69 - 0.185 0.139 -0.493
ENSG00000175354 E026 1.7727912 0.0108351618 6.031647e-01 0.877021549 18 12821336 12821425 90 - 0.414 0.513 0.503
ENSG00000175354 E027 0.1812101 0.0451495662 6.301459e-01   18 12825804 12825809 6 - 0.103 0.000 -10.193
ENSG00000175354 E028 73.5591943 0.0016462671 5.465725e-02 0.357487122 18 12825810 12825944 135 - 1.911 1.847 -0.215
ENSG00000175354 E029 61.7514525 0.0005033299 8.091664e-02 0.419504299 18 12830943 12831041 99 - 1.836 1.777 -0.199
ENSG00000175354 E030 47.8090532 0.0018703178 5.483309e-01 0.853325003 18 12836791 12836823 33 - 1.710 1.695 -0.049
ENSG00000175354 E031 55.9480697 0.0077391323 5.414667e-01 0.850587384 18 12836824 12836891 68 - 1.775 1.755 -0.068
ENSG00000175354 E032 0.0000000       18 12839502 12839557 56 -      
ENSG00000175354 E033 0.7922866 0.0251550867 9.065438e-01   18 12840714 12840962 249 - 0.255 0.244 -0.086
ENSG00000175354 E034 0.0000000       18 12843905 12843981 77 -      
ENSG00000175354 E035 60.9356261 0.0041526178 7.532718e-01 0.933548822 18 12859164 12859254 91 - 1.789 1.822 0.112
ENSG00000175354 E036 0.0000000       18 12862084 12862639 556 -      
ENSG00000175354 E037 1.3529905 0.0123239990 5.806702e-01   18 12862640 12862716 77 - 0.415 0.328 -0.499
ENSG00000175354 E038 1.2454763 0.0492691533 3.047841e-01   18 12862717 12862744 28 - 0.416 0.244 -1.094
ENSG00000175354 E039 1.5118006 0.0305905040 4.117693e-02   18 12863197 12864194 998 - 0.186 0.561 2.301
ENSG00000175354 E040 0.3485388 0.0274156611 8.291209e-01   18 12869025 12869122 98 - 0.103 0.139 0.499
ENSG00000175354 E041 0.1717682 0.0356683422 3.730224e-01   18 12872228 12872269 42 - 0.000 0.139 11.023
ENSG00000175354 E042 0.8543405 0.0165661422 9.082315e-02   18 12880496 12880692 197 - 0.103 0.399 2.500
ENSG00000175354 E043 0.5982085 0.0224586074 7.705643e-01   18 12883618 12884072 455 - 0.185 0.244 0.500
ENSG00000175354 E044 46.5936396 0.0006211480 3.601494e-01 0.746919012 18 12884073 12884338 266 - 1.701 1.672 -0.098
ENSG00000175354 E045 0.0000000       18 12929499 12929643 145 -