ENSG00000174442

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000307897 ENSG00000174442 HEK293_DMSO_6hA HEK293_OSMI2_6hA ZWILCH protein_coding protein_coding 19.5625 7.453917 5.232348 1.930466 0.5715394 -0.5097199 11.2944004 4.8312203 4.26507387 1.5837076 0.40637112 -0.1794214 0.67105000 0.62760000 0.81873333 0.19113333 0.0431529 0.0431529 FALSE TRUE
ENST00000446801 ENSG00000174442 HEK293_DMSO_6hA HEK293_OSMI2_6hA ZWILCH protein_coding protein_coding 19.5625 7.453917 5.232348 1.930466 0.5715394 -0.5097199 1.5214650 0.4472373 0.53301432 0.1708923 0.18394663 0.2480473 0.07178750 0.05763333 0.10146667 0.04383333 0.7393573 0.0431529 FALSE TRUE
ENST00000564179 ENSG00000174442 HEK293_DMSO_6hA HEK293_OSMI2_6hA ZWILCH protein_coding protein_coding 19.5625 7.453917 5.232348 1.930466 0.5715394 -0.5097199 2.0562889 0.0000000 0.00000000 0.0000000 0.00000000 0.0000000 0.06162917 0.00000000 0.00000000 0.00000000   0.0431529 FALSE FALSE
ENST00000565627 ENSG00000174442 HEK293_DMSO_6hA HEK293_OSMI2_6hA ZWILCH protein_coding protein_coding 19.5625 7.453917 5.232348 1.930466 0.5715394 -0.5097199 3.0166213 0.0000000 0.00000000 0.0000000 0.00000000 0.0000000 0.09214583 0.00000000 0.00000000 0.00000000   0.0431529 FALSE TRUE
ENST00000567816 ENSG00000174442 HEK293_DMSO_6hA HEK293_OSMI2_6hA ZWILCH protein_coding protein_coding 19.5625 7.453917 5.232348 1.930466 0.5715394 -0.5097199 0.5894334 1.0052380 0.20760861 0.2199724 0.20760861 -2.2220105 0.03757500 0.16416667 0.03290000 -0.13126667 0.3178964 0.0431529 FALSE FALSE
ENST00000569489 ENSG00000174442 HEK293_DMSO_6hA HEK293_OSMI2_6hA ZWILCH protein_coding protein_coding 19.5625 7.453917 5.232348 1.930466 0.5715394 -0.5097199 0.2833250 0.6462338 0.06836095 0.1534295 0.06836095 -3.0660031 0.02175833 0.09160000 0.01566667 -0.07593333 0.2800607 0.0431529   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000174442 E001 0.0000000       15 66504959 66505082 124 +      
ENSG00000174442 E002 0.0000000       15 66505083 66505116 34 +      
ENSG00000174442 E003 4.1025311 0.0406102755 0.4102947039 0.78051091 15 66505117 66505294 178 + 0.777 0.661 -0.479
ENSG00000174442 E004 3.2423477 0.0436680602 0.2134687430 0.61799982 15 66505295 66505299 5 + 0.728 0.530 -0.863
ENSG00000174442 E005 7.7087560 0.0287454047 0.8503393547 0.96311929 15 66505300 66505325 26 + 0.943 0.928 -0.058
ENSG00000174442 E006 18.2223780 0.0016545990 0.3807918875 0.76056266 15 66505326 66505391 66 + 1.324 1.264 -0.207
ENSG00000174442 E007 0.5735719 0.0200498883 0.2631304929   15 66505392 66505400 9 + 0.302 0.114 -1.740
ENSG00000174442 E008 1.0463959 0.0152086325 0.5757254120   15 66508746 66508840 95 + 0.369 0.278 -0.575
ENSG00000174442 E009 22.0223889 0.0045862550 0.2502892366 0.65610749 15 66508841 66508892 52 + 1.410 1.330 -0.280
ENSG00000174442 E010 0.1767706 0.0379482630 0.4413462979   15 66513934 66513987 54 + 0.126 0.000 -10.732
ENSG00000174442 E011 31.4503531 0.0014169285 0.0890269772 0.43650535 15 66513988 66514083 96 + 1.562 1.465 -0.333
ENSG00000174442 E012 0.1812101 0.0478957497 0.4413905854   15 66514327 66514522 196 + 0.126 0.000 -10.714
ENSG00000174442 E013 38.7386871 0.0010356037 0.1481449100 0.53653975 15 66515526 66515644 119 + 1.639 1.568 -0.242
ENSG00000174442 E014 17.0699820 0.0024200027 0.1732755344 0.57088666 15 66518879 66518882 4 + 1.317 1.212 -0.368
ENSG00000174442 E015 33.3207869 0.0011131742 0.3416181964 0.73326627 15 66518883 66518969 87 + 1.570 1.523 -0.159
ENSG00000174442 E016 39.2683128 0.0109725070 0.2434890177 0.64863470 15 66518970 66519078 109 + 1.645 1.581 -0.220
ENSG00000174442 E017 0.4214379 0.0273753489 0.6585922753   15 66519079 66519129 51 + 0.125 0.204 0.842
ENSG00000174442 E018 0.6524577 0.0202569477 0.0516652378   15 66520508 66520589 82 + 0.000 0.342 11.890
ENSG00000174442 E019 31.3403137 0.0010359711 0.9701041509 0.99305214 15 66520590 66520660 71 + 1.511 1.523 0.042
ENSG00000174442 E020 0.0000000       15 66520661 66520664 4 +      
ENSG00000174442 E021 48.8357893 0.0006099449 0.1767156059 0.57505551 15 66521050 66521205 156 + 1.732 1.676 -0.188
ENSG00000174442 E022 0.6825723 0.0193874923 0.3794834651   15 66523511 66523676 166 + 0.126 0.279 1.424
ENSG00000174442 E023 39.3612772 0.0007835244 0.7753084344 0.94099432 15 66523677 66523748 72 + 1.593 1.618 0.084
ENSG00000174442 E024 38.6151597 0.0007651932 0.2266533392 0.63160680 15 66527290 66527383 94 + 1.632 1.575 -0.194
ENSG00000174442 E025 32.7677704 0.0009540170 0.6916000185 0.91233124 15 66527857 66527912 56 + 1.542 1.527 -0.049
ENSG00000174442 E026 42.1863013 0.0008564602 0.2642469900 0.66912340 15 66528852 66528957 106 + 1.593 1.662 0.235
ENSG00000174442 E027 38.1353808 0.0007591503 0.1235900689 0.49988700 15 66529494 66529573 80 + 1.538 1.633 0.325
ENSG00000174442 E028 52.8539931 0.0006260691 0.3897209073 0.76678082 15 66532247 66532403 157 + 1.753 1.723 -0.100
ENSG00000174442 E029 29.5890209 0.0010962570 0.4444586060 0.80028441 15 66532985 66533013 29 + 1.511 1.474 -0.129
ENSG00000174442 E030 60.9790284 0.0039712229 0.9345056637 0.98464682 15 66535933 66536069 137 + 1.788 1.807 0.066
ENSG00000174442 E031 29.0179267 0.0337566539 0.9695635722 0.99287678 15 66537168 66537168 1 + 1.468 1.492 0.081
ENSG00000174442 E032 60.9808988 0.0008679404 0.5193504383 0.83982804 15 66537169 66537263 95 + 1.777 1.816 0.129
ENSG00000174442 E033 48.6160998 0.0005942312 0.5907718240 0.87177709 15 66540098 66540152 55 + 1.677 1.713 0.122
ENSG00000174442 E034 45.6528126 0.0035627491 0.5824105870 0.86781949 15 66540153 66540210 58 + 1.646 1.684 0.127
ENSG00000174442 E035 63.2726787 0.0006121739 0.5685736423 0.86171148 15 66546591 66546705 115 + 1.788 1.822 0.115
ENSG00000174442 E036 3.6749018 0.0112571829 0.0002036445 0.02065222 15 66546706 66546887 182 + 0.223 0.845 3.159
ENSG00000174442 E037 1.5851753 0.0131616516 0.2830035717   15 66547243 66547292 50 + 0.302 0.491 1.066
ENSG00000174442 E038 251.1783427 0.0083179465 0.2074903515 0.61142590 15 66548351 66550130 1780 + 2.369 2.423 0.182