ENSG00000173692

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000308696 ENSG00000173692 HEK293_DMSO_6hA HEK293_OSMI2_6hA PSMD1 protein_coding protein_coding 54.5186 24.69568 24.36677 6.414519 4.7271 -0.01933599 49.87773 20.47554 22.83228 5.199352 4.696787 0.1571006 0.9128667 0.8312667 0.9309667 0.0997 0.02277782 0.02277782 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000173692 E001 0.0000000       2 231056685 231056844 160 +      
ENSG00000173692 E002 0.0000000       2 231056845 231056848 4 +      
ENSG00000173692 E003 0.0000000       2 231056849 231056863 15 +      
ENSG00000173692 E004 0.0000000       2 231056864 231056866 3 +      
ENSG00000173692 E005 0.3356707 0.0267490305 9.625091e-01   2 231056867 231056874 8 + 0.123 0.116 -0.089
ENSG00000173692 E006 0.5124413 0.0231989261 5.314044e-01   2 231056875 231056878 4 + 0.219 0.116 -1.091
ENSG00000173692 E007 3.6145097 0.0061613400 7.257308e-01 0.92423191 2 231056879 231056893 15 + 0.692 0.642 -0.212
ENSG00000173692 E008 79.3934284 0.0029511290 7.300571e-01 0.92567374 2 231056894 231057041 148 + 1.914 1.893 -0.070
ENSG00000173692 E009 0.0000000       2 231057173 231057540 368 +      
ENSG00000173692 E010 75.6278787 0.0004396343 4.435644e-01 0.79967671 2 231061267 231061310 44 + 1.898 1.867 -0.105
ENSG00000173692 E011 99.6715453 0.0037446431 1.533473e-01 0.54394486 2 231062248 231062321 74 + 2.034 1.965 -0.232
ENSG00000173692 E012 171.2354682 0.0003918009 7.088923e-02 0.39750217 2 231062506 231062675 170 + 2.264 2.214 -0.166
ENSG00000173692 E013 0.8481121 0.1075006641 5.905542e-01   2 231062676 231062693 18 + 0.301 0.207 -0.709
ENSG00000173692 E014 210.1546097 0.0046486807 6.562434e-01 0.89924283 2 231066906 231067111 206 + 2.332 2.321 -0.040
ENSG00000173692 E015 159.4736035 0.0014476771 7.487906e-01 0.93222545 2 231070025 231070168 144 + 2.212 2.204 -0.026
ENSG00000173692 E016 177.9655676 0.0007058396 4.544393e-01 0.80586784 2 231072189 231072332 144 + 2.265 2.244 -0.072
ENSG00000173692 E017 168.9179357 0.0003243261 2.536960e-01 0.65947737 2 231072333 231072415 83 + 2.248 2.216 -0.105
ENSG00000173692 E018 154.2384330 0.0017322798 5.788513e-01 0.86639388 2 231075511 231075571 61 + 2.204 2.182 -0.075
ENSG00000173692 E019 206.0226095 0.0001994744 6.983334e-01 0.91449788 2 231077034 231077162 129 + 2.323 2.313 -0.033
ENSG00000173692 E020 177.9958590 0.0001916999 4.054237e-01 0.77717205 2 231078659 231078747 89 + 2.267 2.245 -0.073
ENSG00000173692 E021 0.7777814 0.0163897547 7.114027e-01   2 231078917 231079535 619 + 0.218 0.284 0.500
ENSG00000173692 E022 163.6064285 0.0002200676 1.599156e-01 0.55431237 2 231079536 231079614 79 + 2.238 2.200 -0.127
ENSG00000173692 E023 0.3529782 0.0414817946 9.700754e-01   2 231079615 231079770 156 + 0.123 0.117 -0.089
ENSG00000173692 E024 233.5429900 0.0001703009 1.161008e-01 0.48640913 2 231080141 231080314 174 + 2.391 2.355 -0.119
ENSG00000173692 E025 201.3932224 0.0002005761 4.387140e-01 0.79691962 2 231082883 231082994 112 + 2.315 2.296 -0.063
ENSG00000173692 E026 0.8225277 0.0173249417 2.111054e-02   2 231083564 231083566 3 + 0.000 0.404 12.487
ENSG00000173692 E027 306.5456543 0.0001345075 4.858456e-01 0.82245181 2 231083567 231083763 197 + 2.480 2.494 0.047
ENSG00000173692 E028 190.8577518 0.0002354323 2.271361e-01 0.63213355 2 231085019 231085079 61 + 2.266 2.298 0.106
ENSG00000173692 E029 164.2048085 0.0002055684 6.243618e-02 0.37816737 2 231085080 231085114 35 + 2.189 2.240 0.172
ENSG00000173692 E030 183.5990215 0.0002383703 9.853463e-02 0.45454155 2 231087117 231087181 65 + 2.240 2.284 0.147
ENSG00000173692 E031 0.8947374 0.0149078257 9.425632e-01   2 231108564 231109122 559 + 0.296 0.284 -0.084
ENSG00000173692 E032 1.1996949 0.0158144565 9.433313e-01   2 231138115 231138735 621 + 0.362 0.349 -0.080
ENSG00000173692 E033 232.5845739 0.0001755102 1.060957e-01 0.46836479 2 231138736 231138850 115 + 2.348 2.386 0.127
ENSG00000173692 E034 0.5108041 0.0212786920 6.104088e-01   2 231138851 231139070 220 + 0.123 0.208 0.913
ENSG00000173692 E035 241.8809523 0.0001672351 3.086626e-01 0.70695476 2 231146240 231146356 117 + 2.372 2.395 0.079
ENSG00000173692 E036 1.5127781 0.4393161168 7.979720e-01   2 231146357 231149450 3094 + 0.432 0.351 -0.454
ENSG00000173692 E037 0.1767706 0.0576393192 4.639480e-01   2 231151857 231151928 72 + 0.123 0.000 -10.510
ENSG00000173692 E038 0.6892119 0.1148775593 2.928915e-01   2 231151929 231152716 788 + 0.301 0.116 -1.706
ENSG00000173692 E039 1.8516770 0.0183882318 1.101507e-01 0.47587323 2 231152717 231152811 95 + 0.296 0.576 1.500
ENSG00000173692 E040 0.6010108 0.0188370400 3.455447e-01   2 231152812 231153468 657 + 0.122 0.284 1.501
ENSG00000173692 E041 0.9589914 0.0152518687 9.361831e-01   2 231153469 231153563 95 + 0.297 0.284 -0.087
ENSG00000173692 E042 218.4626619 0.0003116587 3.880495e-01 0.76588930 2 231153564 231153666 103 + 2.330 2.350 0.067
ENSG00000173692 E043 1.1508694 0.0140724542 2.855055e-01   2 231153667 231153927 261 + 0.218 0.405 1.238
ENSG00000173692 E044 323.3185970 0.0002335504 5.614086e-01 0.85865009 2 231161340 231161509 170 + 2.506 2.517 0.036
ENSG00000173692 E045 9.2860026 0.0962753954 1.830075e-01 0.58308876 2 231161510 231163084 1575 + 0.855 1.100 0.911
ENSG00000173692 E046 3.3129539 0.0088357030 2.263743e-03 0.08481084 2 231163093 231163587 495 + 0.297 0.794 2.413
ENSG00000173692 E047 2.6294584 0.0286071453 1.496280e-01 0.53899170 2 231163588 231163634 47 + 0.419 0.670 1.177
ENSG00000173692 E048 259.3691466 0.0001664015 8.201525e-01 0.95459165 2 231163635 231163727 93 + 2.416 2.421 0.017
ENSG00000173692 E049 2.2615192 0.0084627833 6.817792e-01 0.90881179 2 231164959 231165199 241 + 0.471 0.539 0.328
ENSG00000173692 E050 241.9120852 0.0045358894 7.884499e-01 0.94471572 2 231165200 231165286 87 + 2.393 2.381 -0.039
ENSG00000173692 E051 1.1354408 0.1546965885 9.074362e-01   2 231165287 231165287 1 + 0.352 0.349 -0.014
ENSG00000173692 E052 338.8954053 0.0002408149 4.734018e-01 0.81564604 2 231165871 231166017 147 + 2.540 2.527 -0.046
ENSG00000173692 E053 6.7615384 0.0295066336 2.770736e-01 0.68069863 2 231166018 231166380 363 + 0.794 0.966 0.658
ENSG00000173692 E054 3.3872154 0.0064282460 6.213942e-01 0.88459685 2 231166381 231166491 111 + 0.596 0.671 0.328
ENSG00000173692 E055 13.5061177 0.1104204747 7.536423e-02 0.40780771 2 231166492 231167229 738 + 0.952 1.275 1.168
ENSG00000173692 E056 10.8011811 0.0055268410 6.177752e-05 0.01029889 2 231170402 231170565 164 + 0.771 1.214 1.648
ENSG00000173692 E057 170.3713478 0.0002498728 4.802633e-01 0.81932104 2 231170566 231170578 13 + 2.225 2.244 0.065
ENSG00000173692 E058 336.8102574 0.0003235963 1.160031e-01 0.48627030 2 231170579 231170721 143 + 2.546 2.513 -0.109
ENSG00000173692 E059 34.1101566 0.0024872802 7.314289e-02 0.40251177 2 231170722 231171521 800 + 1.482 1.593 0.378
ENSG00000173692 E060 238.7483379 0.0031958141 4.454196e-01 0.80094147 2 231172535 231173116 582 + 2.368 2.387 0.065