ENSG00000173137

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000308860 ENSG00000173137 HEK293_DMSO_6hA HEK293_OSMI2_6hA ADCK5 protein_coding protein_coding 4.444765 7.020952 6.77653 0.5303702 0.7822938 -0.05104595 1.4019321 1.0942201 1.996714 0.1387362 0.2465797 0.86180719 0.29640000 0.15520000 0.29403333 0.138833333 0.04404376 0.04404376 FALSE TRUE
ENST00000529654 ENSG00000173137 HEK293_DMSO_6hA HEK293_OSMI2_6hA ADCK5 protein_coding nonsense_mediated_decay 4.444765 7.020952 6.77653 0.5303702 0.7822938 -0.05104595 0.5693120 0.8476241 1.172766 0.3947480 0.6627344 0.46374750 0.14144583 0.13056667 0.15383333 0.023266667 1.00000000 0.04404376 TRUE TRUE
ENST00000532190 ENSG00000173137 HEK293_DMSO_6hA HEK293_OSMI2_6hA ADCK5 protein_coding retained_intron 4.444765 7.020952 6.77653 0.5303702 0.7822938 -0.05104595 0.6832064 1.8216484 1.374154 0.4254601 0.2148799 -0.40413807 0.15416250 0.25333333 0.20266667 -0.050666667 0.74796145 0.04404376 FALSE FALSE
ENST00000534714 ENSG00000173137 HEK293_DMSO_6hA HEK293_OSMI2_6hA ADCK5 protein_coding processed_transcript 4.444765 7.020952 6.77653 0.5303702 0.7822938 -0.05104595 0.2192504 0.3506759 0.331766 0.0540946 0.1579098 -0.07769434 0.05257083 0.05163333 0.04536667 -0.006266667 0.91991998 0.04404376 FALSE FALSE
MSTRG.32257.6 ENSG00000173137 HEK293_DMSO_6hA HEK293_OSMI2_6hA ADCK5 protein_coding   4.444765 7.020952 6.77653 0.5303702 0.7822938 -0.05104595 1.1349831 2.5021487 1.412069 0.3515038 0.7081627 -0.82093057 0.24934167 0.35356667 0.23493333 -0.118633333 0.75080590 0.04404376 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000173137 E001 2.6558428 0.0080417811 0.728719820 0.9253148 8 144373101 144373260 160 + 0.520 0.573 0.247
ENSG00000173137 E002 0.8000913 0.0169417310 0.604239619   8 144373810 144373836 27 + 0.299 0.207 -0.700
ENSG00000173137 E003 1.4971688 0.0460971020 0.692859078   8 144373837 144373892 56 + 0.425 0.346 -0.446
ENSG00000173137 E004 0.7503425 0.0172671820 0.149542367   8 144374042 144374045 4 + 0.365 0.116 -2.113
ENSG00000173137 E005 0.9048032 0.0153787590 0.371794542   8 144374046 144374046 1 + 0.365 0.207 -1.113
ENSG00000173137 E006 1.0173198 0.0141771456 0.222770282   8 144374047 144374047 1 + 0.422 0.207 -1.434
ENSG00000173137 E007 2.2390828 0.0087155202 0.233585344 0.6385429 8 144374048 144374054 7 + 0.599 0.402 -0.964
ENSG00000173137 E008 2.4641159 0.0077543359 0.103245156 0.4630256 8 144374055 144374060 6 + 0.665 0.402 -1.251
ENSG00000173137 E009 7.4341754 0.0427932883 0.297653029 0.6979057 8 144374061 144374075 15 + 0.995 0.852 -0.540
ENSG00000173137 E010 15.0553679 0.0034556053 0.123056029 0.4989448 8 144374076 144374107 32 + 1.267 1.131 -0.484
ENSG00000173137 E011 3.1822265 0.0072575357 0.954647917 0.9895397 8 144375466 144375637 172 + 0.599 0.607 0.035
ENSG00000173137 E012 0.9271131 0.0168870413 0.078806560   8 144377393 144377490 98 + 0.423 0.116 -2.436
ENSG00000173137 E013 35.4029639 0.0073287475 0.251963513 0.6577657 8 144379387 144379490 104 + 1.597 1.511 -0.293
ENSG00000173137 E014 45.7521904 0.0096555903 0.623264277 0.8853733 8 144383081 144383230 150 + 1.677 1.645 -0.111
ENSG00000173137 E015 13.0684982 0.0051687686 0.001514895 0.0687087 8 144389263 144389336 74 + 0.935 1.250 1.141
ENSG00000173137 E016 39.9797592 0.0008488904 0.458706166 0.8078293 8 144390671 144390746 76 + 1.586 1.625 0.130
ENSG00000173137 E017 18.5783499 0.0197707851 0.227439247 0.6324418 8 144390747 144390855 109 + 1.204 1.339 0.475
ENSG00000173137 E018 19.4885562 0.0019018198 0.142454762 0.5287854 8 144390856 144390860 5 + 1.242 1.355 0.394
ENSG00000173137 E019 59.8129899 0.0005309634 0.239403776 0.6445749 8 144390861 144391056 196 + 1.749 1.798 0.168
ENSG00000173137 E020 4.0378193 0.0346989107 0.183877598 0.5842304 8 144391057 144391064 8 + 0.565 0.769 0.867
ENSG00000173137 E021 49.7098440 0.0007357590 0.891103122 0.9739069 8 144391134 144391274 141 + 1.703 1.694 -0.031
ENSG00000173137 E022 0.3312313 0.0298158342 0.969472775   8 144391275 144391276 2 + 0.124 0.115 -0.118
ENSG00000173137 E023 45.8294069 0.0007754210 0.787239424 0.9443352 8 144391361 144391474 114 + 1.658 1.669 0.037
ENSG00000173137 E024 46.2404413 0.0007840604 0.202980574 0.6068259 8 144391580 144391711 132 + 1.639 1.699 0.206
ENSG00000173137 E025 22.7496857 0.0076705811 0.086042138 0.4299812 8 144391712 144391782 71 + 1.301 1.435 0.465
ENSG00000173137 E026 36.3375535 0.0010960874 0.478117112 0.8182873 8 144391783 144391866 84 + 1.551 1.589 0.128
ENSG00000173137 E027 35.7139565 0.0214141000 0.971960594 0.9933952 8 144391941 144392022 82 + 1.572 1.559 -0.042
ENSG00000173137 E028 22.4999946 0.0020485906 0.377752208 0.7585222 8 144392092 144392170 79 + 1.410 1.343 -0.231
ENSG00000173137 E029 27.6392663 0.0037922110 0.465157031 0.8112905 8 144392254 144392345 92 + 1.490 1.435 -0.188
ENSG00000173137 E030 53.9745572 0.0057878982 0.150393884 0.5399315 8 144392445 144392697 253 + 1.780 1.701 -0.267
ENSG00000173137 E031 43.7299418 0.0007140899 0.500367966 0.8298186 8 144392776 144392892 117 + 1.664 1.628 -0.124
ENSG00000173137 E032 50.2492311 0.0007188068 0.441929568 0.7987410 8 144392969 144393242 274 + 1.728 1.689 -0.131