ENSG00000172037

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000305544 ENSG00000172037 HEK293_DMSO_6hA HEK293_OSMI2_6hA LAMB2 protein_coding protein_coding 38.81442 62.62439 48.80588 2.910344 10.43165 -0.3596044 12.899903 14.162238 16.692059 1.2020578 1.9588248 0.23695836 0.35935000 0.22540000 0.3564000 0.131000000 0.01958824 0.01958824 FALSE TRUE
ENST00000418109 ENSG00000172037 HEK293_DMSO_6hA HEK293_OSMI2_6hA LAMB2 protein_coding protein_coding 38.81442 62.62439 48.80588 2.910344 10.43165 -0.3596044 2.313331 2.535749 2.673288 0.8364526 0.5020408 0.07591213 0.06310417 0.04013333 0.0587000 0.018566667 0.74132122 0.01958824 FALSE TRUE
ENST00000467506 ENSG00000172037 HEK293_DMSO_6hA HEK293_OSMI2_6hA LAMB2 protein_coding retained_intron 38.81442 62.62439 48.80588 2.910344 10.43165 -0.3596044 3.751783 6.884630 5.255916 0.3697087 0.7715947 -0.38878856 0.08897083 0.11050000 0.1137667 0.003266667 1.00000000 0.01958824 FALSE TRUE
ENST00000469665 ENSG00000172037 HEK293_DMSO_6hA HEK293_OSMI2_6hA LAMB2 protein_coding retained_intron 38.81442 62.62439 48.80588 2.910344 10.43165 -0.3596044 3.431717 7.635174 5.169829 0.1011684 1.4087926 -0.56164475 0.08607083 0.12226667 0.1037667 -0.018500000 0.67899997 0.01958824 FALSE TRUE
ENST00000498377 ENSG00000172037 HEK293_DMSO_6hA HEK293_OSMI2_6hA LAMB2 protein_coding retained_intron 38.81442 62.62439 48.80588 2.910344 10.43165 -0.3596044 6.071804 12.275240 8.769625 0.7367094 2.6539440 -0.48469474 0.14790000 0.19756667 0.1724000 -0.025166667 0.75129599 0.01958824 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000172037 E001 1.0146441 0.4689641013 4.938893e-01   3 49121114 49121114 1 - 0.207 0.398 1.294
ENSG00000172037 E002 103.7852344 0.0083320924 7.718008e-01 0.939914748 3 49121115 49121256 142 - 2.001 2.032 0.105
ENSG00000172037 E003 229.3649119 0.0029304215 7.418101e-01 0.929831831 3 49121257 49121362 106 - 2.361 2.357 -0.012
ENSG00000172037 E004 45.6527210 0.0011685571 6.487265e-04 0.042469286 3 49121363 49121432 70 - 1.551 1.740 0.644
ENSG00000172037 E005 325.2614310 0.0008931039 4.998929e-02 0.344192263 3 49121433 49121592 160 - 2.530 2.488 -0.141
ENSG00000172037 E006 1.0651022 0.3038009178 6.320464e-01   3 49121593 49121596 4 - 0.225 0.352 0.884
ENSG00000172037 E007 389.0126501 0.0008744911 6.902824e-02 0.393598966 3 49121684 49121860 177 - 2.605 2.570 -0.117
ENSG00000172037 E008 399.7448228 0.0001977833 8.208955e-01 0.954757653 3 49121944 49122085 142 - 2.590 2.600 0.035
ENSG00000172037 E009 432.0827191 0.0001666181 7.085966e-01 0.918224919 3 49122163 49122370 208 - 2.623 2.635 0.042
ENSG00000172037 E010 92.0314263 0.0682818053 2.412497e-02 0.254876638 3 49122371 49122493 123 - 1.839 2.049 0.706
ENSG00000172037 E011 96.6523044 0.0652665448 2.926459e-02 0.276634642 3 49122494 49122703 210 - 1.864 2.069 0.690
ENSG00000172037 E012 497.7938655 0.0012879757 4.155969e-02 0.319096453 3 49122704 49123052 349 - 2.713 2.675 -0.128
ENSG00000172037 E013 54.0515876 0.0203952411 2.596950e-03 0.091347467 3 49123053 49123131 79 - 1.595 1.823 0.773
ENSG00000172037 E014 426.2953545 0.0024001971 9.923684e-01 0.998181527 3 49123132 49123324 193 - 2.619 2.631 0.041
ENSG00000172037 E015 224.4411262 0.0038147085 3.259528e-01 0.721515243 3 49123325 49123373 49 - 2.319 2.371 0.172
ENSG00000172037 E016 27.8313542 0.0016429687 3.386604e-05 0.006843789 3 49123374 49123446 73 - 1.270 1.562 1.009
ENSG00000172037 E017 354.0630524 0.0012082776 7.756414e-01 0.941108784 3 49123447 49123631 185 - 2.535 2.550 0.051
ENSG00000172037 E018 5.3421823 0.1041164434 6.754365e-01 0.906316572 3 49123720 49123727 8 - 0.765 0.799 0.133
ENSG00000172037 E019 315.0412589 0.0019635168 7.362485e-01 0.927842914 3 49123728 49123958 231 - 2.483 2.503 0.068
ENSG00000172037 E020 229.3438214 0.0023669068 1.070024e-01 0.469966557 3 49123959 49124100 142 - 2.321 2.386 0.217
ENSG00000172037 E021 194.4468303 0.0011974998 6.887047e-01 0.911346192 3 49124190 49124286 97 - 2.285 2.281 -0.010
ENSG00000172037 E022 2.4970692 0.0080941704 2.505424e-02 0.258980245 3 49124287 49124394 108 - 0.296 0.672 1.920
ENSG00000172037 E023 154.7590180 0.0002598364 3.374252e-01 0.730038697 3 49124395 49124442 48 - 2.194 2.172 -0.072
ENSG00000172037 E024 295.4035308 0.0001363095 8.007003e-01 0.948462372 3 49124443 49124612 170 - 2.462 2.462 0.001
ENSG00000172037 E025 1.3282029 0.0127888103 9.302376e-01   3 49124613 49124623 11 - 0.363 0.349 -0.081
ENSG00000172037 E026 1.2236420 0.0129322118 1.291539e-01   3 49124681 49124700 20 - 0.470 0.209 -1.663
ENSG00000172037 E027 214.9574176 0.0001763569 4.954405e-01 0.827068856 3 49124701 49124810 110 - 2.331 2.321 -0.035
ENSG00000172037 E028 138.7483198 0.0002513090 6.414710e-01 0.893008816 3 49124811 49124851 41 - 2.139 2.131 -0.027
ENSG00000172037 E029 176.3677883 0.0002183189 5.984681e-01 0.875014766 3 49124852 49124925 74 - 2.244 2.236 -0.028
ENSG00000172037 E030 0.9836890 0.1150418268 1.392639e-01   3 49125005 49125005 1 - 0.123 0.403 2.222
ENSG00000172037 E031 243.8964560 0.0001741794 5.589172e-01 0.857618100 3 49125006 49125169 164 - 2.385 2.377 -0.025
ENSG00000172037 E032 8.8703521 0.0127954960 4.244396e-04 0.032682839 3 49125170 49125204 35 - 0.693 1.135 1.683
ENSG00000172037 E033 85.8005577 0.0003877360 5.754769e-01 0.864598000 3 49125253 49125268 16 - 1.941 1.926 -0.053
ENSG00000172037 E034 126.0177524 0.0002637337 7.833417e-01 0.943096711 3 49125269 49125286 18 - 2.089 2.103 0.049
ENSG00000172037 E035 251.0225024 0.0001732665 7.360275e-01 0.927771219 3 49125287 49125484 198 - 2.395 2.393 -0.006
ENSG00000172037 E036 17.3048076 0.0937780099 3.893060e-01 0.766530956 3 49125485 49125539 55 - 1.210 1.285 0.264
ENSG00000172037 E037 42.5383293 0.0546612470 3.970306e-02 0.313154261 3 49125540 49125746 207 - 1.513 1.716 0.690
ENSG00000172037 E038 214.0953846 0.0033000479 9.977042e-01 0.999332791 3 49125747 49125890 144 - 2.326 2.326 -0.003
ENSG00000172037 E039 242.6997031 0.0001807368 4.447098e-01 0.800419580 3 49125967 49126159 193 - 2.365 2.388 0.075
ENSG00000172037 E040 1.1659375 0.0166294014 6.486006e-01   3 49126160 49126183 24 - 0.363 0.285 -0.497
ENSG00000172037 E041 0.6652648 0.0525782573 3.523203e-01   3 49126363 49126364 2 - 0.123 0.284 1.497
ENSG00000172037 E042 188.1629889 0.0007274985 3.847724e-01 0.763536471 3 49126365 49126497 133 - 2.254 2.281 0.093
ENSG00000172037 E043 159.5868508 0.0002248301 6.741553e-01 0.905651859 3 49128458 49128572 115 - 2.187 2.204 0.057
ENSG00000172037 E044 92.8199167 0.0010511418 5.908741e-01 0.871819288 3 49128573 49128585 13 - 1.951 1.974 0.079
ENSG00000172037 E045 3.5349709 0.0059302726 7.949558e-01 0.946490473 3 49128586 49128660 75 - 0.629 0.672 0.183
ENSG00000172037 E046 156.5700594 0.0002162553 3.316521e-01 0.725830888 3 49128661 49128819 159 - 2.201 2.179 -0.075
ENSG00000172037 E047 184.6201914 0.0001936425 8.597820e-01 0.965628193 3 49129020 49129152 133 - 2.259 2.259 0.003
ENSG00000172037 E048 142.7688854 0.0002442831 4.488078e-01 0.802905107 3 49129245 49129324 80 - 2.134 2.161 0.093
ENSG00000172037 E049 174.0199826 0.0008382506 6.866102e-01 0.910557499 3 49129604 49129716 113 - 2.226 2.240 0.047
ENSG00000172037 E050 213.0656915 0.0001997015 6.346561e-02 0.380550526 3 49129839 49130018 180 - 2.343 2.303 -0.135
ENSG00000172037 E051 221.0038622 0.0001916951 2.942203e-02 0.277145166 3 49130231 49130419 189 - 2.363 2.316 -0.156
ENSG00000172037 E052 180.0035129 0.0002665495 9.626871e-01 0.991467572 3 49130740 49130860 121 - 2.248 2.251 0.012
ENSG00000172037 E053 94.7542435 0.0053672200 7.568881e-01 0.934812066 3 49130950 49130964 15 - 1.970 1.978 0.024
ENSG00000172037 E054 242.8963916 0.0022692625 7.212886e-01 0.922646149 3 49130965 49131152 188 - 2.374 2.385 0.036
ENSG00000172037 E055 140.1861516 0.0002619868 4.824038e-01 0.820587580 3 49131379 49131442 64 - 2.123 2.150 0.090
ENSG00000172037 E056 191.0822970 0.0007363726 2.057247e-01 0.609601393 3 49131535 49131723 189 - 2.251 2.293 0.140
ENSG00000172037 E057 92.6297260 0.0050432675 8.822667e-01 0.971764916 3 49132116 49132154 39 - 1.960 1.966 0.022
ENSG00000172037 E058 83.7257239 0.0005655612 6.667188e-01 0.903008678 3 49132155 49132189 35 - 1.922 1.911 -0.037
ENSG00000172037 E059 154.2527715 0.0002213986 5.212207e-03 0.129313178 3 49132270 49132405 136 - 2.221 2.146 -0.250
ENSG00000172037 E060 177.2968563 0.0019149774 7.454762e-03 0.152039517 3 49132491 49132663 173 - 2.291 2.200 -0.305
ENSG00000172037 E061 134.2234015 0.0027120144 7.673484e-02 0.410699071 3 49132792 49132868 77 - 2.162 2.090 -0.241
ENSG00000172037 E062 112.8061486 0.0022913701 1.249244e-01 0.502246558 3 49132869 49132954 86 - 2.080 2.020 -0.202
ENSG00000172037 E063 99.7567708 0.0020285145 1.518664e-01 0.541977266 3 49132955 49133118 164 - 2.024 1.970 -0.182