ENSG00000171103

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000306108 ENSG00000171103 HEK293_DMSO_6hA HEK293_OSMI2_6hA TRMT61B protein_coding protein_coding 11.81716 4.455754 4.522489 1.352475 0.8194697 0.02139973 8.8722908 2.8952574 3.3459893 0.84692896 0.6850386 0.2080721 0.74112500 0.6542 0.73363333 0.07943333 0.621097156 0.003987201 FALSE  
ENST00000490390 ENSG00000171103 HEK293_DMSO_6hA HEK293_OSMI2_6hA TRMT61B protein_coding retained_intron 11.81716 4.455754 4.522489 1.352475 0.8194697 0.02139973 0.1394099 0.2511866 0.0000000 0.01319025 0.0000000 -4.7070088 0.01457917 0.0645 0.00000000 -0.06450000 0.003987201 0.003987201    
MSTRG.18153.1 ENSG00000171103 HEK293_DMSO_6hA HEK293_OSMI2_6hA TRMT61B protein_coding   11.81716 4.455754 4.522489 1.352475 0.8194697 0.02139973 0.8117852 0.4392945 0.3658743 0.19936514 0.3098853 -0.2574112 0.07210417 0.0971 0.06466667 -0.03243333 0.765074500 0.003987201 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000171103 E001 2.304029 0.0096735656 0.1702223789 0.56730273 2 28849821 28849839 19 - 0.628 0.406 -1.067
ENSG00000171103 E002 3.119228 0.0311553150 0.6478331081 0.89564692 2 28849840 28849860 21 - 0.658 0.579 -0.348
ENSG00000171103 E003 13.721820 0.0021420393 0.4913875217 0.82518351 2 28849861 28849924 64 - 1.202 1.146 -0.200
ENSG00000171103 E004 27.305746 0.0012534311 0.7150067087 0.92038702 2 28849925 28850111 187 - 1.466 1.446 -0.069
ENSG00000171103 E005 33.315812 0.0034846302 0.1873127586 0.58843199 2 28850112 28850242 131 - 1.500 1.587 0.297
ENSG00000171103 E006 35.117537 0.0085747380 0.4977507096 0.82829657 2 28850328 28850405 78 - 1.548 1.593 0.155
ENSG00000171103 E007 20.023311 0.0148646333 0.1526178040 0.54286365 2 28851072 28851098 27 - 1.266 1.388 0.424
ENSG00000171103 E008 36.152060 0.0009908692 0.1047845425 0.46630579 2 28851099 28851190 92 - 1.528 1.621 0.318
ENSG00000171103 E009 36.132987 0.0009604315 0.2946365209 0.69518016 2 28851191 28851268 78 - 1.544 1.605 0.207
ENSG00000171103 E010 18.908526 0.0131203456 0.7970723871 0.94734777 2 28851269 28851272 4 - 1.294 1.312 0.064
ENSG00000171103 E011 19.627355 0.0036769542 0.8884699744 0.97336705 2 28851273 28851298 26 - 1.330 1.318 -0.041
ENSG00000171103 E012 26.324075 0.0011776236 0.5734474293 0.86367302 2 28852408 28852499 92 - 1.470 1.436 -0.116
ENSG00000171103 E013 37.227486 0.0113653792 0.6581431673 0.89994129 2 28861118 28861308 191 - 1.594 1.575 -0.065
ENSG00000171103 E014 2.333765 0.0085182509 0.0008288690 0.04852729 2 28861309 28861490 182 - 0.122 0.701 3.630
ENSG00000171103 E015 1.258471 0.0134094911 0.1796644371   2 28861912 28861949 38 - 0.217 0.456 1.516
ENSG00000171103 E016 1.211049 0.1515078567 0.0922306415   2 28863322 28863427 106 - 0.121 0.495 2.733
ENSG00000171103 E017 23.286920 0.0136456944 0.9470187534 0.98757404 2 28865017 28865119 103 - 1.386 1.388 0.005
ENSG00000171103 E018 4.851561 0.0051617456 0.7551373150 0.93432738 2 28869560 28869578 19 - 0.792 0.751 -0.160
ENSG00000171103 E019 95.783841 0.0003962336 0.0007397945 0.04577693 2 28869579 28870309 731 - 2.048 1.944 -0.350