ENSG00000170571

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000303221 ENSG00000170571 HEK293_DMSO_6hA HEK293_OSMI2_6hA EMB protein_coding protein_coding 10.29286 2.991645 2.520143 1.040965 0.1615075 -0.2465344 6.8738659 2.2605101 2.33720041 0.78081051 0.19383700 0.04792456 0.76755000 0.75760000 0.925100000 0.16750000 0.01717738 0.01717738 FALSE TRUE
ENST00000505896 ENSG00000170571 HEK293_DMSO_6hA HEK293_OSMI2_6hA EMB protein_coding retained_intron 10.29286 2.991645 2.520143 1.040965 0.1615075 -0.2465344 0.4043519 0.5712971 0.14369995 0.22749738 0.05547588 -1.91915901 0.05247083 0.18483333 0.060233333 -0.12460000 0.27803851 0.01717738 FALSE TRUE
ENST00000506190 ENSG00000170571 HEK293_DMSO_6hA HEK293_OSMI2_6hA EMB protein_coding processed_transcript 10.29286 2.991645 2.520143 1.040965 0.1615075 -0.2465344 1.9250777 0.0000000 0.00000000 0.00000000 0.00000000 0.00000000 0.10404167 0.00000000 0.000000000 0.00000000   0.01717738 FALSE FALSE
MSTRG.26151.1 ENSG00000170571 HEK293_DMSO_6hA HEK293_OSMI2_6hA EMB protein_coding   10.29286 2.991645 2.520143 1.040965 0.1615075 -0.2465344 0.9926008 0.1598375 0.02005412 0.03620566 0.02005412 -2.49852011 0.06980000 0.05756667 0.007233333 -0.05033333 0.30242496 0.01717738 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000170571 E001 2.721539 0.033256634 5.800214e-02 0.36623522 5 50383170 50383278 109 - 0.369 0.688 1.531
ENSG00000170571 E002 162.002732 0.005855812 6.949509e-01 0.91337410 5 50396192 50398026 1835 - 2.215 2.208 -0.025
ENSG00000170571 E003 50.804050 0.002754463 3.981172e-01 0.77206191 5 50398027 50398676 650 - 1.735 1.694 -0.139
ENSG00000170571 E004 21.388134 0.008599163 3.008163e-01 0.70052512 5 50398677 50398938 262 - 1.396 1.319 -0.265
ENSG00000170571 E005 14.881305 0.001850958 7.746568e-01 0.94076965 5 50398939 50399106 168 - 1.190 1.217 0.096
ENSG00000170571 E006 17.732793 0.018087508 8.828370e-01 0.97190915 5 50399107 50399290 184 - 1.276 1.287 0.038
ENSG00000170571 E007 9.850533 0.014508068 9.289433e-01 0.98306472 5 50399859 50399913 55 - 1.055 1.045 -0.035
ENSG00000170571 E008 9.843006 0.002898683 4.444518e-01 0.80028441 5 50402286 50402319 34 - 1.072 0.997 -0.274
ENSG00000170571 E009 13.259704 0.003007803 1.144286e-01 0.48327686 5 50403178 50403255 78 - 1.219 1.080 -0.498
ENSG00000170571 E010 26.391923 0.003162441 8.213073e-01 0.95484955 5 50403256 50403454 199 - 1.438 1.425 -0.046
ENSG00000170571 E011 19.298574 0.002911842 6.962151e-01 0.91375801 5 50405725 50405852 128 - 1.284 1.315 0.108
ENSG00000170571 E012 17.610934 0.001901192 5.757976e-01 0.86474804 5 50410877 50410965 89 - 1.244 1.289 0.161
ENSG00000170571 E013 12.415623 0.012170466 9.994879e-01 0.99988244 5 50411197 50411221 25 - 1.130 1.121 -0.031
ENSG00000170571 E014 18.207517 0.001812865 1.280520e-01 0.50737393 5 50411222 50411383 162 - 1.217 1.339 0.427
ENSG00000170571 E015 12.086588 0.024294229 6.693399e-05 0.01077897 5 50411384 50411998 615 - 0.761 1.272 1.892
ENSG00000170571 E016 7.434180 0.003641236 3.932992e-01 0.76901214 5 50428144 50428227 84 - 0.974 0.878 -0.363
ENSG00000170571 E017 0.000000       5 50428459 50428727 269 -      
ENSG00000170571 E018 6.422577 0.003772541 7.407588e-02 0.40443610 5 50441040 50441417 378 - 0.974 0.761 -0.823
ENSG00000170571 E019 0.000000       5 50442952 50442984 33 -      
ENSG00000170571 E020 0.000000       5 50443190 50443248 59 -