ENSG00000170473

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000398213 ENSG00000170473 HEK293_DMSO_6hA HEK293_OSMI2_6hA PYM1 protein_coding protein_coding 38.02602 30.91321 44.69289 2.377848 7.022807 0.5316779 11.272204 10.389146 8.105825 1.0270219 1.0233938 -0.3576554 0.32155417 0.33560000 0.1858333 -0.14976667 0.0006735490 0.0003557599 FALSE TRUE
ENST00000408946 ENSG00000170473 HEK293_DMSO_6hA HEK293_OSMI2_6hA PYM1 protein_coding protein_coding 38.02602 30.91321 44.69289 2.377848 7.022807 0.5316779 21.382573 16.519981 31.760924 1.6957783 5.7704508 0.9426220 0.53170000 0.53236667 0.7045000 0.17213333 0.0003557599 0.0003557599 FALSE TRUE
ENST00000549939 ENSG00000170473 HEK293_DMSO_6hA HEK293_OSMI2_6hA PYM1 protein_coding protein_coding 38.02602 30.91321 44.69289 2.377848 7.022807 0.5316779 2.399429 1.868189 1.797233 0.2338972 0.1897488 -0.0555603 0.06449583 0.06226667 0.0413000 -0.02096667 0.6466199600 0.0003557599   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000170473 E001 0.6892119 0.1356847598 0.4599733862   12 55901413 55901413 1 - 0.271 0.132 -1.280
ENSG00000170473 E002 80.3133255 0.0004732895 0.5986414837 0.87505027 12 55901414 55901500 87 - 1.895 1.915 0.066
ENSG00000170473 E003 285.8516157 0.0002301081 0.0066452338 0.14368150 12 55901501 55901686 186 - 2.425 2.479 0.181
ENSG00000170473 E004 461.6081596 0.0001780265 0.6985123462 0.91452931 12 55901687 55901970 284 - 2.657 2.663 0.018
ENSG00000170473 E005 245.4269928 0.0001859662 0.5564620770 0.85657797 12 55901971 55902040 70 - 2.393 2.380 -0.045
ENSG00000170473 E006 477.0161849 0.0001269331 0.3996387030 0.77318742 12 55902041 55902355 315 - 2.682 2.669 -0.044
ENSG00000170473 E007 208.7571591 0.0002285430 0.0140391348 0.20295894 12 55903387 55903480 94 - 2.348 2.288 -0.199
ENSG00000170473 E008 1.4306537 0.0131794744 0.4927000968   12 55913746 55913825 80 - 0.327 0.445 0.670
ENSG00000170473 E009 18.8610535 0.0015647111 0.6766516813 0.90690665 12 55913826 55914018 193 - 1.284 1.315 0.108
ENSG00000170473 E010 41.2291358 0.0185045825 0.3876495102 0.76561044 12 55914019 55914275 257 - 1.593 1.659 0.227
ENSG00000170473 E011 37.8106263 0.0122551605 0.0380033471 0.30701404 12 55914276 55914366 91 - 1.511 1.663 0.520
ENSG00000170473 E012 4.4998006 0.0052046911 0.1199277832 0.49341095 12 55915443 55915531 89 - 0.612 0.828 0.886
ENSG00000170473 E013 62.4576009 0.0006218358 0.0013388812 0.06397482 12 55927076 55927267 192 - 1.731 1.871 0.474
ENSG00000170473 E014 3.7713250 0.0068854345 0.7082873662 0.91808326 12 55927318 55927724 407 - 0.716 0.660 -0.233
ENSG00000170473 E015 126.8019058 0.0031686330 0.0004502136 0.03383422 12 55927725 55927894 170 - 2.169 2.024 -0.486
ENSG00000170473 E016 0.0000000       12 55932529 55932618 90 -